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To effectively position the tunnel emergency situations and improve emergency response efficiency, a tunnel emergency positioning system based on Beidou technology has been designed. The types of emergency events, positioning requirements, and the characteristics of positioning technology in highway tunnels are analyzed. Based on the Beidou beacon, the Beidou emergency terminal, and various communication methods, data integration is achieved on the Beidou emergency resource monitoring platform, integrating multimedia scheduling platform to release and receive unified platform information, and providing personnel, equipment, and other positioning data to on-site rescue personnel and rear command personnel quickly, accurately, and effectively. After testing, the time used on positioning is 60.33 s, the positioning error is ≤ 0.6 m, and the time used on data transmission is 0.19 s, which can meet the emergency rescue needs of the tunnel. [ABSTRACT FROM AUTHOR]

Federated learning technology solves the problems of data islands and privacy leakage to a certain extent.However it has shortcomings such as high communication cost,unstable communication,and uneven distribution of participant performance.In order to overcome these shortcomings and achieve a balance between model effectiveness,fairness,and communication costs,an improved NSGA-III algorithm for multi-objective optimization of federated learning is proposed.First,a federated learning multi-objective optimization model is constructed to maximize the accuracy of the global model,minimize the variance of the global mo-del accuracy distribution and minimize the communication cost of participant,and an improved NSGA-III algorithm based on fast greedy initialization is proposed,which improves the efficiency of NSGA-III for multi-objective optimization of federated learning.Experimental results show that the proposed optimization method can obtain a better Pareto solution than the classical multi-objective evolutionary algorithm.Compared with the standard model of federated learning,the optimized model can effectively lower the communication cost and the variance of the global model accuracy distribution while ensuring the accuracy of the global model.

Objective To investigate the effect of tumor necrosis factor receptor-associated factor 6 (TRAF6) on barrier and targeted binding of miR-125b to TRAF6 in human pancreatic ductal epithelial cell line HPDE6C7. Methods TRAF6 expression HPDE6C7 cells were up-regulated by recombinant lentivirus infection. The protein expression of nuclear factor κB(NF-κB) pathway and tight junction were examined by Western blot, the permeability of monolayer HPDE6C7 cells was measured with Transwell cab to evaluate the epithelial barrier function, and the targeted binding of miR-125b to TRAF6 was identified by dual-luciferase reporter assay. Results After up-regulation of TRAF6 expression by HPDE6C7 cells, the protein level of NF-κB p65, TGFβ-activated kinase 1(TAK1) and TAK1-binding 1 (TAB1) was increased, and the protein level of occludin and claudin-1 was decreased(P＜0.05), the permeability increased significantly (P＜0.05). Dual-luciferase reporter assay confirmed that TRAF6 was the target gene of miR-125b. Conclusions TRAF6 potentially play a role in affecting the pancreatic ductal epithelial barrier by regulating the NF-κB signaling pathway, which may be inhibited by miR-125b targeted binding to TRAF6.

Objective: The aim of the study was to investigate the impact of the sites of high-resolution human leukocyte antigen (HLA) mismatch on the prognosis of children with leukemia undergoing umbilical cord blood transplantation (UCBT). Methods: Clinical data and high-resolution HLA-A, HLA-B, HLA-C, HLA-DRB1 and HLA-DQB1 locus gene information were collected in the children who underwent the UCBT for the first time at Children's Hospital of Soochow University between January 2016 and June 2023. In each locus, according to whether the two genes were compatible, they were divided into a compatible group (two genes were perfectly matched) and a non-compatible group (one gene was not matched). In different loci, the differences in occurrence, recurrence, non-recurrence death and survival of acute graft versus host disease (aGVHD) were compared between the two groups. Multivariate Cox regression was employed to analyzed the influencing factors for overall survival rate, and Fine-Gray proportional hazards model was employed to analyze the influencing factors of other outcome events. Results: A total of 100 patients were enrolled (55 males and 45 females), whose age [ M ( Q 1 , Q 3 )] at the time of transplantation was 3.9 (2.0, 6.5) years. There were 55 cases in the HLA-A matched group and 45 cases in the mismatched group. The 5-year non-recurrence mortality (NRM) in the HLA-A matched group was lower than that in the mismatched group ( P =0.024). The cumulative incidence of aGVHD within 100 days after transplantation in the HLA-A matched group was lower than that in the mismatched group ( P =0.017), and there were no statistically significant differences in other outcome events between the groups (all P >0.05). There were 70 cases in the HLA-B matched group and 30 cases in the mismatched group. The 5-year cumulative recurrence rate in the HLA-B matched group was higher than that in the mismatched group ( P =0.027). There were 79 cases in the HLA-C matched group and 21 cases in the mismatched group, and there were no statistically difference in the outcome events between the groups ( P >0.05). There were 73 cases in HLA-DRB1 matched group and 27 cases in mismatched group. The 5-year overall survival rate in HLA-DRB1 matched group was higher than that in mismatched group ( P =0.036), the 5-year cumulative recurrence rate in HLA-DRB1 matched group was higher than that in mismatched group ( P =0.028), and the 5-year NRM in HLA-DRB1 matched group was lower than that in mismatched group ( P =0.008). The cumulative incidence of aGVHD within 100 days after transplantation in the matched group was lower than that in the mismatched group ( P =0.010), and and there were no statistically significant difference in other outcome events between the groups ( P >0.05). There were 68 cases in HLA-DQB1 matched group and 32 cases in mismatched group. There was no statistical difference in outcome events between the two groups (all P >0.05). The risk of aGVHD in HLA-A mismatched group was higher than that in HLA-A matched group ( HR =1.25, 95% CI : 1.12-1.38). The risk of recurrence in HLA-B mismatched group was lower than that in HLA-B matched group ( HR =0.77, 95% CI : 0.63-0.91). Mismatched group at HLA-DRB1 compared with matched group at HLA-DRB1, had a higher risk of aGVHD ( HR =1.37, 95% CI : 1.26-1.48), a higher risk of non-recurrence death ( HR =1.39, 95% CI: 1.28-1.50), and a higher risk of death ( HR =1.27, 95% CI : 1.18-1.36). No association was found between HLA-C and HLA-DQB1 locus with the risk of aGVHD, recurrence, non-recurrence death, and survival (all P >0.05). Conclusions: In UCBT, the risk of aGVHD in children with matching HLA-A sites of donor and recipient is lower than that in children with incompatible HLA-A sites. Compared with children with incompatible HLA-DRB1 sites, children with HLA-DRB1 matched sites has a lower risk of acute GVHD, a lower 5-year NRM, and a higher risk of death. The recurrence rate of children with matching HLA-B loci is higher than that of children without matching HLA-B loci.

This paper reported 1 case of poisoning caused by stramonium. Cases of Datura poisoning have been reported nationwide, Its effect on the central nervous system of patients is characterized by first excitation and then inhibition, clinical manifestations include decreased gland secretion, dilated pupils, and tachycardia, etc. Its poisoning mechanism is anticholinergic effect, the effect on Peripheral nervous system is to inhibit Parasympathetic nervous system. Hemoperfusion combined with neostigmine anticholinergic therapy at the early stage of poisoning can effectively improve the clinical symptoms of patients in a short time.

Objective: To study the respiratory tract infections by Mg, M. genitalium (Mpn), Cpn, and co-infections by these agents in pediatric patients., Methods: Mg DNA, Mpn DNA and Cpn DNA were detected in respiratory tract specimens obtained by throat swab from 231 children by the nested polymerase chain reaction (PCR) technique. DNA sequencings were detected and analysed between every two positive specimens of Mg and Cpn and typical strains., Results: Positive rates of Mg DNA, Mpn DNA and Cpn DNA by nested PCR in 231 children were 22.5%, 30.7% and 32.9%. The Positive rates of co-infection were 5.2% (Mg and Mpn), 2.6% (Mg and Cpn), 10.8% (Mpn and Cpn) and 8.7% (Mg and Mpn and Cpn). There was only one base mutation in 1 Mg DNA. Other DNA sequencings were same as those from model strains. The homogeneity was 99.8%., Conclusions: Mg could be one of the pathogens in respiratory tract infections in pediatric patients. There exists co-infection by Mg, Mpn and Cpn.

HSV specific antibody IgG was detected in the sera and CSF of 43 patients with sporadic encephalitis by the initial and follow-up tests with ELISA. Twelve cases of HSE were diagnosed, accounting for 27.8% of the cases of sporadic encephalitis, the clinical manifestations of HSE and NHSSE were compared. Differences were observed with regard to the age, general states, mental symptoms, disturbance of consciousness, and fatality rate. The abnormalities in EEG, CSF examination and CT scanning were found to be more severe in the HSE cases. It was concluded that these differences would be of use only as a diagnostic aid where as additional specific tests would be necessary for an accurate diagnosis of herpes simplex encephalitis.