1. Recent findings with regard to roles of GGA2 in vesicle transport and related diseases.
- Author
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TAO Yihao, MUTAILIFU, Baierna, QI Zhengfang, LIU Changwu, TIAN Yuan, and HAN Yangyang
- Subjects
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CARRIER proteins , *TYPE 2 diabetes , *MOLECULAR structure , *PROTEIN transport , *CEREBRAL ischemia - Abstract
Cellular dysfunction caused by vesicle transport is associated with a variety of diseases. The trans-Golgi network (TGN) to endosome transport is an important pathway of vesicle transport, and its defects leading to protein balance disorders has been linked to many diseases such as cancer, neurodegenerative diseases and diabetes mellitus. Golgi-associated gamma-adaptin ear-containing ADP-ribosylation factor-binding protein 2 (GGA2) is a crucial protein involved in TGN-endosomal transport. It plays a significant role in the regulation of several diseases, including cancer, Alzheimer disease, type 2 diabetes mellitus and cerebral ischemia, by mediating protein transport with important biological significance. This article provides an overview of the molecular structure of GGA2, its role in regulating clathrin-mediated protein transport between TGN and endosomes, and its potential implications for a variety of diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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