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Objective To analyze the epidemic characteristics of breakthrough cases of varicella in Shapingba District, Chongqing, and provide reference for the prevention and control of the varicella epidemic in the area.[WTHZ]Methods [WTBZ]Collect information on varicella cases and their vaccination in Shapingba District from 2019 to 2023, Use descriptive epidemiological methods to analyze the epidemiological characteristics of varicella breakthrough cases, and use linear regression to analyze the relationship between breakthrough cases and age at the time of vaccination and the time interval between vaccination and onset of disease.[WTHZ]Results [WTBZ]From 2019 to 2023, there were a total of 802 breakthrough cases of varicella in Shapingba District, Chongqing, accounting for 14.87% of the total number of varicella cases. The majority of cases were vaccinated with one dose of varicella (648 cases, accounting for 80.80%), and the differences in composition among different years were statistically significant (χ²=16.400, P<0.005); The epidemic has a bimodal distribution, from October to December and May to July each year. The least cases are in winter (142 cases, accounting for 11.68%), and the most cases are in spring (198 cases, accounting for 17.32%). The composition differences between different seasons are statistically significant (χ2=16.348, P<0.001); The breakthrough cases of chickenpox are mainly male, with the highest incidence among primary school students aged 6～10, and the differences in composition are statistically significant (χ²=877.420, P<0.001); The time interval from the first dose of chickenpox vaccine to the onset of breakthrough cases was 46 days to 17 years, with a median\[M(P25, P75)\] of 7 years (4 years, 10 years). The median time interval between scattered children, primary school students, and middle school students was 3 years (2 years, 4 years), 8 years (6 years, 9 years), and 12 years (11 years, 14 years), respectively, with statistical significance (H=497.280, P<0.001); There is a negative correlation between age at the time of first dose vaccination and the interval between onset of the disease in breakthrough cases, with a correlation coefficient of r=-0.230 (t=-6.693, P<0.001).[WTHZ]Conclusion [WTBZ]Breakthrough cases of varicella in Shapingba, Chongqing are mainly concentrated in primary school students during the start of the school season, with an interval of 7 years between onset. It is necessary to further strengthen the prevention and control of the varicella epidemic in primary schools, further improve the vaccination rate of children with varicella vaccines, and recommend receiving two doses of vaccines before starting primary school to reduce the risk of breakthrough cases. [ABSTRACT FROM AUTHOR]

ObjectiveTo analyze the epidemiological characteristics of varicella in Karamay City, to inform the prevention and control of the local varicella epidemic, and to guide adjustments to the varicella vaccine immunization strategy.MethodsThe data on varicella cases from 2015 to 2022 in Karamay were collected and the epidemiological characteristics were analyzed.ResultsA total of 3 380 varicella cases were reported in Karamay from 2015 to 2022, with an average annual incidence rate of 94.91/105. The incidence of varicella showed a year-on-year downward trend from 2015 to 2022 (AAPC=-16.29%, P

ObjectiveTo explore the exposure-lag-response relationship between temperature and risk of varicella incidence,and to provide a scientific evidence for early warning and precise prevention and control of varicella epidemic.MethodsDaily varicella cases and daily meteorological data were collected in Minhang District, Shanghai from 2010 to 2022. A distributed lag nonlinear model was used to determine the exposure-lag-response relationship between temperature and risk of varicella incidence. Furthermore, effect of temperature on the incidence risk was determined across different age groups.ResultsIn 2010‒2022, the total number of notified varicella cases was 26 207 in Minhang District, with the highest incidence in the group aged 3‒14 years (50.35%). The seasonal pattern of daily varicella cases showed a double peak. The large peak was found in November and December, followed by a smaller peak in May and June. Moreover, the distributed lag nonlinear model showed a unimodal curve in the relationship between temperature and varicella incidence. The RR value reached its maximum peak of 1.90 (95%CI: 1.25‒2.87) at 7 ℃. A reverse U-shape was found in the lag-response curves between temperature and varicella incidence. Furthermore, the effect of temperature on the varicella incidence showed a unimodal pattern in the varicella cases aged 3‒14 years. The RR value reached its peak at 11 ℃ (RR=2.89, 95%CI: 1.33‒6.24). In contrast, the effect of temperature on the varicella incidence in the cases aged 15 years and above showed a unimodal pattern, with RR value reaching the peak at 5 ℃ (RR=2.14, 95%CI: 1.33‒3.44).ConclusionThe unimodal curve is found in the relationship between temperature and varicella incidence. Low temperature is associated with increased risk of varicella incidence. Children aged 3‒14 years are more susceptible to the effect of temperature on the varicella incidence.

Objective To analyze the epidemiological characteristics of varicella and effectiveness of varicella vaccine in Jinan. Methods We collected data of varicella surveillance in Jinan from 2006 to 2022 from the Chinese Information System for Disease Control and Prevention and vaccination data for children born during 2010-2021 form the Jinan Immunization Planning Information System. All reported varicella cases from 2006 to 2022 in Jinan were analyzed with descriptive epidemiological methods; Coverage and effectiveness of varicella vaccine for children born during 2010 to 2021 were conducted with the screening method. Results 61 145 cases of varicella were reported in Jinan during 2006-2022, yielding an annual average incidence of 51.82 per 100 000 population; the incidence ranged from 74.48 per 100 000 in 2008 to 28.47 per 100 000 in 2022. Peak varicella incidences occurred between April and June and between November and the following January. The highest incidence rate was 5-9 years old group from 2006-2016 and was 15-19 years old group from 2017 to 2022. Coverage levels for one doses was 77.32% in the 2010-2021 births; the overall effectiveness of varicella vaccine was 91.83% (95%CI: 91.43%-92.30%). Coverage levels for two doses was 45.86% in the 2010-2018 births; the overall effectiveness of varicella vaccine was 95.14%(95%CI: 94.56%-95.66%). Conclusion The high incidence age group shifted from 5-9 years old to 15-19 years old. It was suggested that the vaccine administration should be used to targeted age groups. Levels of vaccine effectiveness for 2 doses of varicella vaccine were greater than levels of Vaccine effectiveness for one-doses. We suggest to introduce 2 dose of varicella vaccine into the national immunization program for children. [ABSTRACT FROM AUTHOR]

Objective To analyze the epidemiological distribution characteristics of chickenpox in Urumqi City from 2015 to 2023, to construct a prediction model by combining Baidu search keywords, and to explore the complementary application of Baidu index in chickenpox prevention and monitoring. Methods Descriptive epidemiological methods were used to analyze the characteristics of varicella case triple distribution in Urumqi City from 2015 to 2023. Chickenpox keywords were identified and a comprehensive Baidu search index was constructed. The models ARIMA and ARIMAX were constructed, the prediction effectiveness of the two models was evaluated by mean absolute error (MAE), mean absolute percentage error (MAPE), and root mean square error (RMSE). Results The average annual reported incidence rate of varicella in Urumqi was 80.85/100 000, with a higher incidence in men than in women (χ² = 1.136, P = 0.287), there were statistically significant differences in incidence rates by age group (χ² = 7 582.372, P < 0.001), seven districts and one county had different average annual incidence rates (χ² = 21.496, P < 0.001), with the highest in the Toutunhe district (100.54/100 000). ARIMAX(1,1,0)(1,0,0)52 was selected as the best prediction model (prediction set MAE 12.04%, RMSE 13.80%, MASE 1.18%) with a good fitting effect. Conclusion The ARIMAX prediction model established based on the search term Baidu index has a certain degree of predictability and sensitivity, and can predict the epidemic trend of chickenpox in Urumqi in time, which can be used as a technical support and further expansion of the traditional monitoring and early warning system. [ABSTRACT FROM AUTHOR]

Objective To analyze the epidemiological characteristics of notifiable infectious diseases in Tongzhou District of Nantong from 2017 to 2022, and provide scientific basis for developing targeted prevention and control strategies and measures. Methods Descriptive epidemiological methods were used to analyze the reported data of notifiable infectious diseases in Tongzhou District of Nantong from 2017 to 2022. Results From 2017 to 2022, a total of 25 379 cases of 26 types of notifiable infectious diseases were reported in Tongzhou District of Nantong, with an average annual incidence of 33.80 per 10 000. There were 27 deaths, with an average annual mortality rate of 0.04 per 10 000. Among the reported cases, the ratio of male to female reported incidence was 1.34∶1. The highest incidence of infectious diseases was observed in the age group under 10 years, mainly due to cases of varicella and hand-foot-mouth disease. The main occupational groups affected were farmers, preschool children, students, scattered children, and homemakers / unemployed individuals. Digestive tract infectious diseases such as hand-foot-mouth disease and other infectious diarrhea were mainly reported in summer, while respiratory tract infectious diseases such as varicella were more common in winter. The areas with the highest incidence were Xianfeng Street, Jinsha Street, and Xingren Town. The main types of infectious diseases reported were respiratory and intestinal tract infections. The top three reported diseases in terms of incidence rate were varicella, hand-foot-mouth disease, and syphilis. Conclusion In 2017—2022, the reported incidence of notifiable infectious disease in Tongzhou District of Nantong has showed a trend of fluctuating decline. However, it is still necessary to strengthen the monitoring and prevention of varicella and hand-foot-mouth disease, pay attention to the publicity and intervention of sexually transmitted diseases (such as syphilis), and maintain the incidence and mortality of notifiable infectious diseases at a low level compared to the national average.

Copyright of China Tropical Medicine is the property of China Tropical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

ObjectiveTo analyze the epidemiological characteristics of varicella in Yangpu District， Shanghai from 2005 to 2022， predict the trend of varicella in Yangpu District in 2023， and provide evidence for prevention and control of varicella outbreaks.MethodsInformation of varicella cases reported in Yangpu District from 2005 to 2022 was obtained from the China Information System for Disease Control and Prevention. Descriptive statistics was used to characterize the varicella epidemiology. An autoregressive integrated moving average （ARIMA） model was established by using the number of cases per month from 2005 to2022 to predict the trend of varicella epidemics in Yangpu District in 2023. The varicella incidence in 2022 was used to evaluate the fitness of the ARIMA model.ResultsFrom January 2005 to December 2021， a total of 11 527 cases of varicella were reported in Yangpu District， Shanghai. After excluding duplicates and clinical diagnoses， 11 413 cases were included into the analysis. The annual average incidence rate was 51.87/105， the age of onset was mainly under 20 years old （66.5%）， and the occupation was mainly students （49.7%）. The ARIMA （1，1，0）×（0，1，1）12 model was constructed and showed a good fitness while using monthly reported varicella cases in 2022 for model fitting. It was predicted that 1 089 cases of varicella would be reported in Yangpu District in 2023.ConclusionIt is predicted that varicella cases in Yangpu District will increase in 2023. It is recommended to continue promoting delayed varicella vaccination to maintain a high level of vaccination rate. Before the peak of the epidemic， health education regarding varicella should be strengthened， and measures for epidemic prevention and control should be reinforced to prevent varicella outbreaks.

ObjectiveTo evaluate the effectiveness of the varicella vaccine immunization strategy in Shanghai， and to provide evidence for enhancing prevention and control measures by analyzing the incidence and trends of varicella in Songjiang District， Shanghai from 2013 to 2021.MethodsA descriptive analysis was conducted on 12 417 varicella cases reported in Songjiang District between 2013 and 2021. The epidemiological distribution of varicella cases was described， and the incidence rates were compared among different demographic variables， including registered residence， gender， age， and occupation.ResultsA total of 12 417 varicella cases were reported in Songjiang District from 2013 to 2021，with an average annual incidence of 77.03/105. The incidence of varicella showed an increasing trend from 2013 to 2017 （χ2trend=19.39， P

ObjectiveTo analyze the epidemiological characteristics of varicella in Minhang District， Shanghai from 2013 to 2022， and to evaluate the impact of adjusting the varicella vaccination program to a two-dose regimen and its inclusion in the Shanghai immunization program on the incidence of varicella.MethodsData on reported varicella cases from 2013 to 2022 in Minhang District were collected. Interrupted time series analysis and segmented regression models were used to analyze the changes in varicella incidence before and after the adjustment of varicella immunization strategies.ResultsFrom 2013 to 2022， the average annual incidence of varicella was 76.58/100 000， with the highest incidence in 2017 （119.21/100 000） and the lowest in 2022 （27.02/100 000）. The varicella incidence exhibited seasonal patterns with peaks occurring from March to June and October to January of the following year. Prior to the adjustment of varicella immunization strategies （2013‒2017）， the varicella incidence showed an upward trend （z=2.20， P=0.03）， while after the adjustment （2018‒2022）， a adownward trend was observed （2018‒2022） （z=-2.25， P=0.02）. Interrupted time series analysis showed that following the adjustment of varicella immunization strategies， an immediate change of -33.91/100 000 （t=-4.35， P

Objective To analyze the epidemiological characteristics of varicella in Guiyang city and to provide scientific basis for formulating appropriate prevention and control measures and immunization strategies for varicella. Methods The data of varicella incidence, resident population, and vaccination in Guiyang were collected through China Disease Prevention and Control Information Management system and Guizhou Immunization Planning Information Management system. Descriptive epidemiological methods were used to analyze the epidemiological characteristics and vaccination of varicella vaccine in Guiyang City from 2010 to 2022. Results A total of 32 405 varicella cases were reported in Guiyang city from 2010 to 2022, with an average annual incidence of 54.39/100 000. The incidence of varicella in people under 15 years old was 75.46%. The incidence of varicella was relatively stable from 2011 to 2016 and then increased in 2017 and 2021, while the proportion of female cases in the total population showed an upward trend (S=56.000, τ=0.718, P < 0.001). The incidence of 0 to < 3 years old showed a downward trend, increased continuously in 3 to < 5 years old, reached a peak in 5 to < 6 years old, and then decreased gradually. The incidence percentage of the whole population aged 10 to < 15 and 15 to < 20 years old showed an increasing trend. The two peak incidence rates were from November to January and from May to July, respectively, and the incidence rates in Guanshan Lake district and Baiyun district were higher than those in other districts (cities and counties). The incidence of varicella in Guiyang city over the years was negatively correlated with the number of two doses of varicella vaccine in the same year (r=-0.610, P=0.027). Conclusion The incidence of varicella in Guiyang city shows a downward trend, with obvious seasonal, regional, and population characteristics, and the incidence is mainly among students under 15 years old. The better the second dose of varicella vaccine is, the lower the incidence is, so it is necessary to strengthen the inspection of varicella vaccination in enrollment. On the other hand, considering the increasing incidence of people aged 10 to < 15 and 15 to < 20 years old in Guiyang, it is necessary to strengthen the publicity and varicella vaccination for students of all ages. [ABSTRACT FROM AUTHOR]

Objective To analyze the prevalence trend, spatial epidemic characteristics and temporal and spatial distribution characteristics of varicella in Linyi City, Shandong Province, from 2010 to 2020,and to explore the high-risk areas of varicella in 12 counties of Linyi City, Shandong Province, so as to provide theoretical basis for health administration departments to formulate reasonable prevention and control measures. Methods The data of varicella cases in 12 counties of Linyi City, Shandong Province from 2010 to 2020 were collected through the Chinese Disease Prevention and Control Information System, and the basic situation was analyzed by descriptive epidemiology. Spatial autocorrelation and temporal scanning were used to study the temporal and spatial distribution of varicella in Linyi City, Shandong Province. Results The annual average incidence of varicella was 8. 82/100 000 in Linyi City, Shandong Province from 2010 to 2020. There was no obvious linear relationship between the incidence and the time distribution, and there was a statistically significant difference in incidence rate in different years and counties (P＜0. 05). There were obvious regional differences in incidence, and the incidence tended to decrease with distance from the central area. The incidence rate of varicella in men (10. 15/100 000) was higher than that in women (7. 44/100 000),with a statistically significant difference (P＜0. 05). There were cases in all ages, with the highest incidence of 5-＜10 years old (36. 32/100 000),and the difference was statistically significant (P＜0. 05). With the increase of age, the incidence showed a significant decreasing trend. There was a significant spatial positive correlation between the incidence of varicella in Linyi city, Shandong Province from 2010 to 2020. Lanshan District, Hedong District, and Luozhuang District were high to high clustering areas, while Yishui County, Yinan County, and Tancheng County were low to low clustering areas. Lanshan District, Hedong District and Luozhuang District were high incidence hot spots, while Yishui County, Yinan County and Tancheng County were cold spots, and the other areas had no obvious significance. The high-high clustering area was also a high incidence hot spot area, while the low-low clustering area was also the cold spot area with regional correspondence. The spatial prediction results were basically consistent with the regional distribution of varicella disease. The spatiotemporal clustering analysis detected that a type of clustering area occurred in the central region of Linyi City, Shandong Province from 2010 to 2020,mainly consisting of three counties and districts: Lanshan District, Luozhuang District, and Hedong District. The clustering period was from 2018 to 2020. Conclusion The incidence of varicella in Linyi City, Shangdong Province has obvious spatial and temporal clustering. The incidence rate can be effectively reduced by carrying out epidemic surveillance, implementing health education, guiding high-risk personnel to vaccinate varicella vaccine in time and other comprehensive prevention and control measures, and strengthening the allocation of epidemic prevention and control personnel and prevention and control resources in the areas where the incidence of varicella is concentrated. [ABSTRACT FROM AUTHOR]

ObjectiveTo analyze the varicella cases from the illness-induced absenteeism system and the National Notifiable Disease and Reporting System （NNDRS） in primary and secondary school students in Minhang District， determine the characteristics of varicella-induced absenteeism in schools， and provide scientific evidence for the prevention and control of varicella in schools.MethodsSurveillance data of varicella-induced absenteeism and varicella cases in the NNDRS in 2021 were collected. Characteristics of varicella-induced absenteeism and consistency of data between the illness-induced absenteeism system and the NNDRS were determined， using descriptive analysis and matching varicella cases in the two systems.ResultsThe incidence of varicella in Minhang District was 48.28/105 in 2021. The overall rate of illness-induced absenteeism was 612.08/105 in primary and secondary schools， and the rate of varicella-induced absenteeism was 6.03/105. The distribution of varicella-induced absenteeism was consistent with the incidence of varicella cases. Furthermore， the rate of varicella-induced absenteeism was significantly higher in boys than in girls. The rate increased synchronously during the peak of varicella incidence. The rate differed significantly across the students in diverse schools （χ2=135.217，P

ObjectiveTo analyze the epidemiological characteristics and the vaccination status of the cases in Jing’an District from 2017 to 2019， so as to provide reference basis for the strategy of prevention and control of varicella epidemic.MethodsDescriptive epidemiological methods were used to analyze the epidemiological characteristics of varicella in Jing’an District. The differences between the vaccinated group and the unvaccinated group were compared by statistical methods.ResultsA total of 2 508 cases of varicella were reported with an average annual incidence of 78.7/105 from 2017 to 2019. There was no significant difference in the incidence among the three years（χ2=5.535，P=0.063）. There were 1 308 males and 1 200 females， and sex ratio was 1.1∶1. The highest incidence occurred in the age group from 5 to 9 years old （562 cases， 479.3/105）. Two annual peaks occured in May and November. The incidence in the aged 18 and below decreased year by year. There was significant difference in the proportion among the three years（χ2=78.129， P

ObjectiveTo determine the epidemiological characteristics and transmission factors of a varicella outbreak in a school in Nanxun District of Huzhou City， and assess the effect of prevention and control measures， which may provide scientific evidence for improvement in the response to varicella outbreak.MethodsData were collected by field epidemiological survey and analyzed by descriptive epidemiology. Statistical analysis was performed by SPSS 22.0 software.ResultsA total of 80 varicella cases were identified in this outbreak， which lasted 68 days. There were four peaks of incidence， involving 21 classes. The total incidence rate was determined to be 4.14%. Before the public health intervention， some cases were not isolated in time， which led to the initial spread in the class. After the mid-term examination， the outbreak further spread to multiple classes. Breakthrough varicella cases accounted for 48.75% of all the cases in the outbreak， among which 94.87% had been vaccinated for more than five years. However， there was no significant difference in the incidence of fever and rash between the breakthrough cases and non-breakthrough cases（P>0.05）.ConclusionTimely report， prompt response， and strict implementation of prevention and control measures remain crucial for effective containment of varicella outbreak.

Objective By collecting and sorting the information of varicella cases reported in Liaoning Province from 2006 to 2021, the epidemiological characteristics were analyzed, and the monthly incidence data were predicted, so as to explore the prevention and control strategy of varicella disease in Liaoning Province. Methods By collecting the characteristic information of varicella cases in Liaoning Province, epidemiological analysis was carried out on the regional, population, and temporal characteristics of varicella incidence. The monthly incidence data of varicella were fitted with Eviews software, seasonal ARIMA model was used for modeling, and models were selected according to SC and AIC. After modeling, the model was used to predict the incidence data in 2022. Results The incidence rate of varicella in Liaoning Province has increased in recent years. The onset time was "bimodal distribution", with the main peak occurring from November to January of the next year and the secondary peak occurring from May to June. Since 2019, the onset age has shifted backward. From the original 0-<10 age group with the highest incidence rate, it shifted to the 10-<20 age group with the highest incidence rate. From 2006 to 2021, the incidence of varicella mainly concentrated in people aged 0 to <40 years old, and the incidence rate of the population over 40 years old showed a cliff-like decline. The incidence of chickenpox was higher in the central region of Liaoning Province, such as Shenyang, Dalian, Anshan and Panjin, and relatively low in Huludao, Jinzhou, Fuxin and Liaoyang. The distribution of the population was mainly students, followed by kindergartens and scattered children. ARIMA model of monthly incidence data was established by software as ARIMA (1, 0, 1) (1, 1, 1)12. Conclusions The incidence rate of varicella in Liaoning Province has been rising in recent years. The incidence is obviously seasonal, and the age group of the affected population has moved backward. It is predicted that the incidence will continue to increase in 2022. The prevention and control of varicella should still be the current key work. In order to reduce the population incidence rate, two-dose vaccination strategies should be vigorously promoted the implementation of the, and the inclusion of varicella vaccine in the immunization program should be achieved as soon as possible. [ABSTRACT FROM AUTHOR]

Copyright of China Tropical Medicine is the property of China Tropical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To analyze the changes of varicella outbreak in Minhang District before and after practicing “the varicella emergency vaccination implementation program (2013-2014 trial version),Shanghai”,and to evaluate the effects of live attenuated vaccine against varicella.Methods We used cross-sectional investigation to collect monitoring data of vaticella outbreak recorded in “China Information System for Disease Control and Prevention”.The observation periods before and after the implementation of the program were during 2012-01-01 to 2013-06-30 and during 2013-07-01 to 2014-12-31.Results Before the implementation of the program,14 cases of varicella epidemic were reported in Minhang District.All cases were up to the outbreaks in the epidemic,the longest duration was 82 days,the average duration continued was 50.86 days (912/14),the average cumulative generation was 2.42 generations (50.86/21),the total number of people was 159,the total incidence rate was 1.26% (159/12 625),the class incidence rate was 9.09% (159/1 750),the average number of people was 11.36 (159/14),the average number of class was 3.21 (45/14).After the implementation of the program,169 cases of the varicella epidemic were reported in Minhang District,only 22 cases rose to the outbreaks in the epidemic,the longest duration was 66 days,the average duration continued was 41.32 days (909/22),the average cumulative generation was 1.97 generations (41.32/21),the total number of people was 200,the total incidence rate was 1.10% (200/18 200),the class incidence rate was 8.38% (200/2 387),the average number of people was 9.09 (200/22),the average number of class was 2.50 (55/22);Although the varicella epidemic in the total outbreaks had significantly increased in Minhang District before and after emergency implementation,but the varicella outbreak in the varicella epidemic significantly decreased,the total incidence rate,the class incidence rate,the longest duration,the average duration,the average cumulative generation,the average number of people and the average number of class had decreased in varying degrees.There is statistical difference between the average duration before and after the implementation (χ2=4.06,P<0.05).Conclusions Emergency vaccination of varicella vaccine in high risk population can effectively control the spread of epidemic situation and reduce the possibility of secondary transmission. [ABSTRACT FROM AUTHOR]

Objective To analyze the efficacy of acyclovir combined with high dose intravenous immunoglobulin(IVIG)regimen in the treatment of childhood acute leukemia(AL)complicated with varicella. Methods Thirty children with AL complicated with varicella admitted from January 1, 2016 to June 1,2018 in the infectious department of the hospital were treated with acyclovir combined with high dose IVIG, and the therapeutic effect was observed. Results The fever course of children with AL complicated with varicella was(8.32±3.12)days, the scab formation time of skin lesions was(11.21±2.55)days, the average hospitalization time was(8.99±3.22)days, and 14 cases(46.67%)had secondary skin infections. The cure rate was 100.0%. Among children with AL complicated with varicella, female children were more susceptible to secondary skin infection than male children, and the difference was statistically significant(P<0.05);the fever course, skin scab formation time and hospitalization time of children with acute lymphoblastic leukemia(ALL)complicated with varicella were longer than those of children with acute myeloid leukemia complicated with varicella, and the differences were statistically significant(P<0.05);Among ALL children, the fever duration in induction remission period was longer than that in maintenance treatment period, and the secondary skin infection rate was higher than that in maintenance treatment period, the differences were statistically significant(P<0.05). Conclusion Childhood AL complicated with varicella has the characteristics of long duration of clinical symptoms and decrease of myelosuppressive granulocytes after chemotherapy. After treatment with aciclovir combined with high dose IVIG regimen, the prognosis of children with AL complicated with varicella is good and the mortality is low. [ABSTRACT FROM AUTHOR]

Objective: To analyze the epidemiological characteristics of temporal-spatial distribution on varicella in Guangxi Zhuang Autonomous Region (Guangxi) during 2014 to 2016. Methods: Incidence data on varicella was collected from the National Notifiable Infectious Disease Reporting Information System (NNIDRIS) of the Center for Disease Control and Prevention (CDC) while geographic information data was from the national CDC. ArcGIS 10.2 software was used to analyze global and local spatial auto correlation on spatial clusters. SaTScan v9.1.1 was used to conduct temporal-spatial scan for exploring the areas of temporal-spatial clusters. Results: The overall incidence rates of varicella during 2014 to 2016 were 32.48/100 000, 43.56/100 000 and 61.56/100 000 respectively. Incidence of varicella showed a positive spatial auto correlation at the county level (the value of Moran's I was between 0.24 to 0.35, P <0.01), with consistent high morbidity. High-high cluster areas were seen and mainly concentrated in the north-western areas of Guangxi. Result from the temporal-spatial scan showed that temporal cluster of varicella occurred mainly between October and next January while the type Ⅰ cluster area was mainly distributed in all of the counties in Hechi city and most counties of Baise city, with most counties being covered in the north-western areas of Guangxi, during 2014-2016. When comparing to data from the last two years, two type Ⅱ cluster areas with larger scales were formed in the north-eastern area of Guanyang county and Haicheng county of southern area in Guangxi, in 2016. Conclusions: Incidence on Varicella seemed on the rise, and the distribution of cases showed clustered features, both on time and space. Strategies regarding control and prevention on Varicella should focus on high-high clustered areas, namely north-western areas of the province, including surrounding areas during the high onset season.