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Objective To investigate the clinical features of autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy. Methods We collected and analyzed the clinical and laboratory data and obtained the clinical characteristics of diagnosis and treatment from fifteen patients with positive GFAP antibody tested by cerebrospinal fluid and diagnosed autoimmune GFAP astrocytopathy by the multi-centers. Results The mean age of the first onset of autoimmune GFAP astrocytopathy was 39.73 years old (range 4-65 years), with no significant gender difference. In terms of clinical manifestations, we found the whole brain symptoms including abnormal mental behavior, disturbance of consciousness, epileptic attack accounting for more than 50, , meningitis accounting for 66.7%, myelitis (53.3%), limb tremor (53.3%), vision loss (33.3%); systemic symptoms including fever(100%) and fatigue(86.7%). 46.7% of patients were initially diagnosed with tuberculous meningoencephalitis and were treated with diagnostic antituberculous therapy. The MRI showed 46.7% of patients showed brain linear perivascular radial gadolinium enhancement in the white matter perpendicular to the ventricle. Conclusions Autoimmune GFAP astrocytopathy are acute or subacute dieases and the main clinical features include encephalitis, meningitis, myelitis and optic neuritis. They are likely to be misdiagnosed as tuberculous meningoencephalitis and can manifest progressive loss of consciousness in early phase, which is even life threatening.

In order to improve the low temperature dyeing performance of decolorized green cashmere, the effects of cationic protein auxiliaries and acetic acid on adsorption and dyeing performance, fixing effect, color fastness to soap washing and color fastness to soap washing and color fastness to rubbing dyed with Lanasol reactive dyes were investigated. The results show that both cationic protein auxiliaries and acetic acid could promote the adsorption and dyeing of Lanasol reactive dyes on decolorized green cashmere, but the effect cationic protein auxiliaries on increasing the dye-uptake was less than that of acetic acid. When sodium carbonate is not added for fixation, if the dosage of cationic protein auxiliaries and acetic acid is higher man 2.1% (owf), the effect of cationic protein auxiliaries on improving the fixation rate of Lanasol reactive dye is better than that of acetic acid. After adding sodium carbonate for fixation, the effect of cationic protein auxiliaries on improving the dyeing depth K/S value and total fixation rate of decolorized green cashmere after soap is greater than that of acetic acid. Cationic protein auxiliaries combined with acetic acid are more conducive to improving the fixation rate. At the same time, the use of cationic protein auxiliaries, acetic acid, and their combination in Lanasol dye baths can achieve good color fastness of the dyed cashmere to soaping. The color staining grades of six fibers are above grade 4, the color change fastness, cationic protein auxiliaries have reached grade 4 -- 5, which is better than acetic acid grade 4, but the application of cationic protein auxiliaries will reduce the color fastness to rubbing of dyeing fleece. [ABSTRACT FROM AUTHOR]