1. Enhancement of Innate Immune Function in Mice by Bifidobacterium bifidum FL-228.1
- Author
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Yu ZHOU, Xiaoying TIAN, Qingyu CUI, Zhe ZHANG, Pimin GONG, Kai LIN, Huaxi YI, Tongjie LIU, and Lanwei ZHANG
- Subjects
bifidobacterium bifidum ,innate immunity ,macrophages ,natural killer cells ,antimicrobial peptide ,Food processing and manufacture ,TP368-456 - Abstract
In this study, eight potential functional strains were selected to interfered with RAW264.7 murine macrophages and human peripheral blood mononuclear cells (PBMCs). Then, changes in phagocytic activity of RAW264.7 cells and natural killer (NK) cell activity were detected and the screened potential probiotics were further intervened in BALB/c mice to explore their immunomodulatory efficacy in vivo. In cell experiments, the results showed that the intervention of different strains significantly increased the phagocytic activity of RAW264.7 cells (P0.05). In conclusion, Bifidobacterium bifidum FL-228.1 can improve innate immune function and have a more comprehensive effect on the immune system by regulating immune cell activity, cytokine expression and mRNA levels of immune molecules related to antimicrobial peptides.
- Published
- 2023
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