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In the process of digitisation of medical data,choosing the right technology for efficient processing and accurate analysis of medical data is a common problem faced by the medical field today.The use of knowledge graph technology with the excellent association and reasoning capabilities to process and analyse medical data can better enable applications such as wise information technology of medicine and aided diagnoses.The complete process of constructing a medical knowledge graph includes know-ledge extraction,knowledge fusion and knowledge reasoning.Knowledge extraction can be subdivided into entity extraction,relationship extraction and attribute extraction,while knowledge fusion mainly includes entity alignment and entity disambiguation.Firstly,the constructiontechnologies and practical applications of medical knowledge graphs are summarised,and the development of the technologies is clarified for each specific construction process.On this basis,the relevant techniques are introduced,and their advantages and limitations are explained.Secondly,introducing several medical knowledge graphs that are being successfully applied.Finally,based on the current state of technology and applications of knowledge graphs in the medical field,future research directions for knowledge graphs in technology and applications are given.

Based on the data obtained from the three-coordinate measuring and pre-processing,a NURBS method to reconstruct the complex surface of non-circular bevel gear and a two-step matching method to implement the complex surface error evaluation is proposed. The curve and surface reconstruction of the teeth surface is carried out by NURBS interpolation,and the least square approximation is adopted to gain the model of the reconstruction surface. Integrating ICP and BFGS algorithm,an error evaluation model is built,and the measuring data is initially matched and precisely matched to the design model. The model is solved by MATLAB programming,the Euclid transformation matrix is gotten and then the surface profile error of the gear can be achieved. Finally,the obtained error is 0. 053 22 mm,which meets the requirements of gear design. The calculating results show that this method has high accuracy and speed to reconstruct the surface and can solve the error evaluation problem for the complicated surface.

In view of problems of slow response speed and bad anti-disturbance ability existed in traditional control system of DC motor, the paper proposed a composite double-loop control method of DC motor based on disturbance observer and speed observer. The method adds feed-forward control, disturbance observer and speed observer in PID control of DC motor. The feed-forward control is used to improve response speed and tracking performance of the system. The disturbance observer makes external torque disturbance and output difference between practical object and nominal model caused by parameters change of motor model to be equivalent to control input end, namely observes equivalent disturbance and equivalent compensation is introduced in control, so as to realize complete inhibition for disturbance. The speed observer takes torque command and practical speed of the system as inputs, deploys observing and filtering functions to get observing speed without high-frequency components and lagging behind practical speed of the motor to replace the practical speed, the observing speed is used as feedback signal of speed. Simulation result shows that the method has good robust and reduces vibration phenomena and tracking error of speed and position of the motor caused by measuring noises.

Both NEDC cycle test and road test are conducted on diesel cars fueled with commercial diesel fuels (National 11 diesel fuel and Shanghai IV diesel fuel), biodiesel BD10 and synthetic fuel GTL to compare their fuel economy. The results show that with NEDC cycle, the fuel consumption per 100 km of car fueled with BD10 and GTL are 3.06% and 1.93% more than that with commercial diesel fuels respectively; while in real-world driving, the fuel consumption with BD10 and GTL are 2.23% and 4. 46% more than that with commercial diesel fuels respectively. [ABSTRACT FROM AUTHOR]

Objective To explore the diagnostic value of superb micro-vascular imaging (SMI) for patients with vulnerable plaque of carotid artery. Methods Totally 69 patient with carotid hypoechoic or predominantly hypoechoic plaque (108 plaques),which were identified by conventional ultrasound,underwent SMI and contrast-enhanced ultrasound (CEUS). Based on the scores of CEUS and SMI (0,1,and 2 points),the consistency of SMI and CEUS in detecting plaque neovascularization was assessed. Results SMI could more clearly display the profile and morphology of the plaques than conventional ultrasound. SMI showed that there were neovascularization in 75 plaques,and CEUS showed that there were neovascularization in 76 plaques;the number of scoring consistency in the plaque neovascularization under SMI and CEUS was 90,suggesting these two results were highly consistent (Kappa value=0.748). There were 6 ulcerated carotid plaques detected by SMI,and the same 6 ulcerated carotid plaques were detected by CEUS,showing complete consistency. Of these 108 plaques,55 caused stenosis of the lumen,and SMI showed there was no correlation between plaque neovascularization and stenosis of the lumen caused by plaques (P=0.473). Conclusion SMI can clearly display the morphology and outline of the plaques and the plaque neovascularization. Therefore,it can be used for evaluating plaque vulnerability.

This study was aimed to investigate the effect of COX-2 inhibitor celecoxib on proliferation, apoptosis of human acute myeloid leukemia cell line HL-60 and its mechanism. HL-60 cells were cultured with different concentrations of celecoxib for 24 h. Cell proliferation was analyzed by CCK-8 assay, cell apoptosis and cell cycle distribution were detected by flow cytometry. Cyclin D1, cyclin E1 and COX-2 mRNA expressions were determined by RT-PCR. The results showed that after the HL-60 cells were treated with different concentrations of celecoxib for 24 h, the cell growth was significantly inhibited in a dose-dependent manner(r = 0.955), IC50 was 63.037 µmol/L of celecoxib. Celecoxib could effectively induce apoptosis in HL-60 cells also in dose-dependent manner(r = 0.988), blocked the HL-60 cells in the G0/G1 phase. The expression of cyclin D1, cyclin E1 and COX-2 mRNA were downregulated. It is concluded that celecoxib can inhibit the proliferation of HL-60 cells in dose-dependent manner, celecoxib causes cell G0/G1 arrest and induces cell apoptosis possibly through down-regulation of the cyclin D1 and cyclin E1 expression, and down-regulation of COX-2 expression respectively.

Objective: To explore the efficacy of injectable gelatin matrix as a hemostatic agent for treatment of grade III-IV hepatic trauma to a canine model with contrast-enhanced ultrasound (CEUS) guidance., Methods: Twenty-seven healthy adult dogs underwent celiotomy in induce grade III-IV hepatic trauma in the left lateral lobe of the liver. The dogs were then randomized into 3 groups, namely the treatment group in which the injectable hemostat was percutaneously injected into the injury site under CEUS guidance, and the positive and negative control groups with thrombin solution and normal saline treatment, respectively. Intra-abdominal blood loss within 30 min postoperatively, and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) 7 days postoperatively were compared among the groups. Follow-up CEUS was performed in each animal 7 days after the operation., Results: The mean blood loss was 47.69 ml in the treatment group, significantly less than that in the positive control group (81.77 ml, P/0.01) and negative control group (110.35 ml, P<0.01). The treatment group had also significantly lower ALT and AST levels than the two control groups (ALT: 49.37, 62.81, and 82.83 U/L, respectively, P<0.05; AST: 48.32, 67.16, and 82.54 U/L, respectively, P<0.05). In the treatment group, CEUS did not detect hepatic lesions or ascites as found in the two control groups, and the perfusion of the liver was homogeneous., Conclusion: The injectable hemostat injected under the guidance of CEUS can effectively control grade III-IV hepatic hemorrhage in the canine model and show strong effects of stopping bleeding and promoting wound healing.