1. [Study on volatile components from peel of Aquilaria sinensis and the anti-tumor activity].
- Author
-
Xu WN, Gao XX, Guo XL, Chen YC, Zhang WM, and Luo YS
- Subjects
- Antineoplastic Agents, Phytogenic isolation & purification, Benzylammonium Compounds pharmacology, Breast Neoplasms pathology, Cell Line, Tumor, Cell Proliferation drug effects, Chromones analysis, Chromones pharmacology, Fatty Acids analysis, Fatty Acids pharmacology, Female, Fruit chemistry, Gas Chromatography-Mass Spectrometry methods, Humans, Oils, Volatile chemistry, Oils, Volatile pharmacology, Sesquiterpenes pharmacology, Antineoplastic Agents, Phytogenic pharmacology, Benzylammonium Compounds analysis, Oils, Volatile analysis, Sesquiterpenes analysis, Thymelaeaceae chemistry
- Abstract
Objective: To study the volatile constituents from peel of Aquilaria sinensis (Lour.) Gilg. and its anti-tumor activity., Methods: The volatile components from peel of A. sinensis were extracted by chloroform and analysed by the GC-MS technique. Assay the peel extract of A. sinensis on MCF-7 cell proliferation using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) method., Results: GC-MS gave 131 peaks and 28 compounds have been identified. The contents of the benzene compounds accounted 7.79% of the volatile components, the esquiterpenes accounted 5.44%, and the relative content of fatty acids accounted 3.08%. In addition, two 2-(2-phenylethyl)-color ketones and a chromone component were detected, and the total relative content accounted 12.3%. The inhibition rate of human breast cancer cells reached 99. 6% when the concentration was 500 microg/mL., Conclusion: The volatile components from peel of A. sinensis were analysed and a large number of characteristic elements of A. sinensis were detected for the first time. The chloroform extract from peel of A. sinensis significantly inhibited the proliferation of human breast cancer cells.
- Published
- 2010