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[Introduction] With the large-scale application of new energy, the challenges faced by the grid connection of new energy power generation are growing, and the importance of energy storage system is increasing. carbon dioxide energy storage (CES) technology is a kind of compressed gas energy storage technology emerging in recent years, with the advantages of high energy storage density, long service life and high design flexibility. For liquid carbon dioxide energy storage (LCES) technology, CO2 is stored as liquid phase in both HP and LP sides of the system, which has high energy storage density and strong operation stability. [Method] Firstly, the operation principle and key technical indicators of the LCES system was introduced and the importance of carbon dioxide liquefaction and common liquefaction processes were clarified. Then, the research status of CO2 liquefaction on the LP side of the LCES system was introduced, including the use of mixed energy storage working medium, self-condensation, the LNG cold energy, and the regenerator. The characteristics of each method were analyzed in detail. [Result] The research indicates that the application of regenerator is the most effective method. It is necessary to further analyze the challenges faced by current cold storage liquefaction technology and its development direction. [Conclusion] The research could provide guidance for the further development of CO2 liquefaction technology for the LCES system.

The static headspace(HS) combined with gas chromatography-mass spectrometry(GC-MS) was used to analyze the volatile flavor compounds of Zanthoxylum bungeanum from 45 producing areas in Shanxi, Shandong, Sichuan and Gansu. Using automatic mass spectrometry deconvolution qualitative system(AMDIS) and Kováts Retention index(RI) analysis, a total of 99 volatile compounds were obtained. 79, 69, 68 and 63 volatile compounds were identified in Zanthoxylum bungeanum from Shanxi, Gansu, Shandong and Sichuan province. A variety of mathematical models were established to identify the origin. Among them, the Orthogonal partial least squares(OPLS-DA) model could accurately distinguish Zanthoxylum bungeanum samples from 4 provinces, the model fitting parameter Q2 was 0.84, and the 6 key difference substances(VIP>2) were piperonone, pinene, terpinene, 3-carene, ocirene and α-phellandrene. Further application of GC-MS full-spectrum data combined with Random Forest(RF) model for origin identification could successfully distinguish Zanthoxylum bungeanum from Shanxi, Gansu, Shandong and Sichuan provinces, with an accuracy rate of 100%.

With a greater amount of attention paid to the pollution of the environment caused by coal processing, methods using soil microorganism repairing to improve coking contaminated soil becomes more and more significant. The biodegradation of toluene or benzoate and the nitrate-reducing process were analyzed in coking contaminated soil by the addition of toluene or benzoate as the sole carbon source as well as energy source in enrichment solution under nitrate-reducing, then the structural diversity of anaerobic denitrification microbial community of degradation toluene or benzoate was compared by high throughput sequencing. The molar ratio of toluene or benzoate to nitrate was 1∶8.7 or 1∶5.9, respectively, a reasonable approximation of the theoretical stoichiometric ratios. After 120 days of enrichment, the main bacteria in the coking soil is Proteobacteria, and the advantage phylum of phenol degradation in soil enrichment under the condition of nitrate reduction is Firmicutes, while for benzoate it is Proteobacteria. α-, and γ-proteobacteria, Bacilli is the dominant class in toluene-degrading bacteria, and the dominant class in the degradation of benzoate is β-proteobacteria. The results show that Exiguobacterium is the predominant genus of toluene-degrading bacteria, while Azoarcus is the dominant species in benzoate.

Lung cancer is one of the world's highest morbidity and mortality disease in malignant tumors currently. Squamous-cell lung cancer (SQCLC) is one of the most prevalent subtypes of lung cancer worldwide, after surgery, radiotherapy, chemotherapy and other comprehensive treatment, its 5-year survival rate is still below 15%. The current molecular targeted therapy plays an important role in the treatment of SQCLC, an urgent need to be more in-depth study. SQCLC molecular targeted therapy mainly epidermal growth factor receptor (EGFR), phosphoin-3-kinase catalytic alpha polypeptide (PIK3CA), fibroblast growth factor receptor 1 (FGFR1), discoidin domain receptor 2 (DDR2), phosphatase and tensin homolog deleted on chromosome ten (PTEN), BRAF, MET, insulin-like growth factor 1 receptor (IGF-1R) and other as the target of the drug, some targeted drugs are being developed, and some targeted drugs have entered clinical trials. In recent years, with studies molecular targeted therapy in SQCLC, analysis of the development and trgeted therapy achieved substantial progress in improving the survival rate of SQCLC, and other research to improve the quality of life, make is possible to individualized targeted therapy of SQCLC.

A gas chromatography-mass spectrometry (GC-MS) method was established for the determination of 18 preservatives compounds (methyl chloride isothiazolinone, etc.) in infant cosmetics. The cosmetic samples were extracted with 0.1 mg/mL ascorbic acid methanol as the solvent, separated on an Agilent DB-5 MS chromatographic column (30 m×0.25 mm×0.25 μm) by temperature programming with split injection technique, analyzed by GC-MS, and then quantified by an external standard curve. The results indicate that the effective separation and determination of 18 preservatives can be realized within 20 minutes. The method has good linear relationship with the correlation coefficients (R) greater than 0.998, the limits of detection (LOD) are in the ranges of 0.15-1.50 μg/kg, and the average recoveries at three spiked levels are in the range of 76.7%-104.9%. The method is accurate, rapid, simple, and quite suitable for the simultaneous determination of 18 preservatives in infant cosmetics. [ABSTRACT FROM AUTHOR]

Objective To investigate the relationship between grip strength and physical mobility and bone mineral density(BMD) in elderly hospitalized patients. Methods 235 elderly patients(≥ 60 years) treated in the Department of Geriatrics of the Second Affiliated Hospital of Dalian Medical University from October 2020 to October 2021 were selected to assess their grip strength and physical mobility(gait speed, 5 sitting up test time, and up-and-go test time) and analyze their correlation with BMD. Results Univariate analysis showed that grip strength and gait speed were positively correlated with BMD, and up-and-go test time and 5 sitting up test time were negatively correlated with BMD, and this correlation was present in patients of both genders(P

In order to comprehensively analyze the essential oil components, antioxidant and antibacterial activities of the whole plant of Citrus aurantium var. amara, the essential oils from leaves, flowers and young fruits were extracted respectively by steam distillation (SD) and their chemical compositions were identified by GC-MS. Moreover, their antioxidant and antibacterial activities were evaluated and compared using in vitro methods. The results were as follows: (1) A total of 94 volatile components were isolated and identified from the essential oils of leaves, flowers and young fruits, there were some differences between three parts, of which 13 were common components. A total of 34 components were identified from leaves, and the major compounds were linalool (30.51%) and α-terpineol (14.78%); a total of 32 components were identified from flowers, the main components were linalool (57.59%) and d-limonene (16.15%); a total of 69 components were identified from young fruits, mainly containing d-limonene (25.55%) and γ-terpene (10.48%). (2) The essential oils from different parts showed different antioxidant activities. The IC50 values of essential oils from young fruits, leaves and flowers to ABTS free radicals were 2.6, 5.1 and 8.2 mg·mL-1, respectively, and the IC50 values to DPPH free radicals were 2.7, 4.3 and 5.0 mg·mL-1, respectively. The antioxidant activity of young fruits was better than that of leaves and flowers. (3) The essential oil from young fruits showed certain antibacterial activity against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa, which was better than the leaves and flowers. The results can provide a theoretical basis for the extraction and utilization of the essential oils from different parts of Citrus aurantium var. amara.

Background Schizophrenia often experience severe social discrimination throughout their entire survival period, resulting in self isolation or social isolation. Limited studies have been conducted on social isolation in young and middle-aged patients with schizophrenia in remission. Objective To describe the social isolation experience of young and middle-aged patients with schizophrenia in remission, aiming to provide reference for developing supportive intervention plans to alleviate the social isolation experience of this population. Methods A purposive sampling method was used to select young and middle-aged schizophrenia patients aged 18-59 who had been hospitalized at the Second Affiliated Hospital of Xinxiang Medical University and were willing to continue follow-up after discharge as the research subjects. From May to December 2022, a semi-structured in-depth interview was conducted face-to-face with the respondents, and the themes were summarized and extracted using content analysis method. Results A total of 18 young and middle-aged patients with schizophrenia in remission were included. By analyzing the interview data, a total of 3 themes and 8 sub themes were extracted, including the performance of social isolation in young and middle-aged patients with schizophrenia in remission (containing 2 subthemes of negative emotional experience and withdrawal between expectation and behavior) ; subjective reasons for social isolation in young and middle-aged patients with schizophrenia in remission (containing 2 subthemes of self isolation and self discrimination) , and the objective reasons for social isolation in young and middle-aged patients with schizophrenia in remission (containing 4 subthemes of social discrimination and passive containing, effects of adverse drug reactions, increased burden of living and care caused by mental illness, and the lack of social support) . Conclusion Young and middle-aged patients with schizophrenia in remission may experience social isolation due to impaired physical health, poor psychological status, and insufficient social support. Healthcare professionals should strengthen symptom management and psychological counseling for this population. The government and all sectors of society should actively guide positive perception of mental illness and provide certain social support; family support should be strengthened to help young and middle-aged patients with schizophrenia in remission reintegrate and adapt to society.