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The working environment and lighting conditions of mining intelligent vehicles are complex. When detecting underground personnel, infrared reflection information and detailed texture information can be fused into visible light images by fusing visible and infrared images to improve the target detection effect. Traditional visible and infrared image fusion methods can lead to blurring of image edges and textures as the number of decomposition layers increases, and the fusion time also increases. At present, deep learning based fusion methods for visible and infrared images are difficult to balance the features in visible and infrared images, resulting in blurred detail information in the fused images. In order to solve the above problems, the image fusion algorithm based on multiple attention modules (IFAM) is proposed. Firstly, convolutional neural networks are used to extract image features from visible and infrared images. Secondly, the extracted features are cross fused using spatial attention and channel attention modules. The fusion weights of the output features of the two attention modules are calculated using the gradient information in the features. The output features of the two attention modules are fused based on the weights. Finally, the image features are restored through deconvolution transformation to obtain the final fused image. The fusion results on the RoadScene dataset and TNO dataset indicate that the IFAM fused image contains both background texture information from visible light images and personnel contour feature information from infrared images. The fusion results on the underground dataset indicate that in low lighting environments, infrared images can compensate for the shortcomings of visible light and are not affected by other light sources in the environment. In low lighting conditions, the personnel contour in the fused image is still obvious. The comparative analysis results show that the information entropy (EN), standard deviation (SD), gradient fusion metric (QAB/F), visual information fidelity for fusion (VIFF), and the union structural similarity index measure (SSIMu) of the image after IFAM fusion are 4.901 3, 88.521 4, 0.169 3, 1.413 5, and 0.806 2, respectively. The overall performance is superior to similar algorithms such as LLF-IOI and NDM.

This study aimed to investigate the effect of microRNA-155 (miR-155) in chronic obstructive pulmonary disease (COPD) and cigarette smoke extract (CSE)-treated airway smooth muscle cells (ASMCs) by targeting phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) to regulate the PTEN/PI3K/Akt signaling pathway. The COPD mouse model was induced by lipopolysaccharide (LPS) combined with passive smoking. After modeling, miR-155 mimics and miR-155 inhibitor were used for intervention treatment. The pulmonary function of each group was detected by an EMKA detector. Hematoxylin-eosin (HE) staining was used to observe the pathological changes and scores of lung tissues. The expression of TNF-α, IL-6, and IL-1β in bronchial alveolar lavage fluid (BALF) was detected by ELISA. Primary ASMCs were isolated and cultured in adherent tissue culture. The proliferation activity was detected by CCK-8 and EdU assays. Transwell and wound healing assays were used to measure the migration of ASMCs. The targeting relationship between miR-155 and PIK3R1 was validated by a double luciferase reporter gene assay. The expression levels of miR-155 and PIK3R1 mRNA in lung tissues of mice in each group were detected by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Western blot was used to detect the expression levels of Ki67, PNCA, PTEN, p-PI3K, PI3K, p85α, p-Akt, and Akt in lung tissues and ASMCs. The results showed that lung function was significantly reduced in the miR-155 mimic group, and the levels of PIK3R1 were significantly increased; while lung function in the miR-155 inhibitor group was significantly improved. The results of HE staining showed that there was obvious inflammatory cell infiltration in the miR-155 mimics group compared to that of the model group. Lung histopathological injury was significantly reduced in the miR-155 inhibitor group, accompanied by decreased expression of Ki67, PNCA, PI3K, p-Akt, increased PTEN and p85α protein levels, and reduced levels of TNF-α, IL-6, and IL-1β in BALF. The results of the double luciferase reporter gene assay showed that miRNA-155 could target bind to PIK3R1. Compared with those in the CSE+miR-155 NC group, the proliferation and migration of ASMCs were significantly increased in the CSE+miR-155 group. The proliferation and migration of ASMCs were significantly attenuated in the CSE+miR-155+pcDNA PIK3R1 group compared with those in the CSE+miR-155 group, accompanied by decreased expression of Ki67, PNCA, p-Akt and increased PTEN and p85α protein levels. These results suggest that miR-155 activates the PTEN/PI3K/Akt signaling pathway by targeting PIK3R1 to promote the occurrence and development of COPD, which provides new evidence for the use of miR-155 in the treatment of COPD.

The aim of this paper was to explore the pharmacological mechanism of Baitouweng Decoction in the treatment of ulcerative colitis(UC) by network pharmacology and to preliminarily verify the related targets by animal experiments. Cytoscape software was used to construct "ingredient-target-disease" network through TCMSP, GeneCards and Uniprot databases. The protein interaction network was constructed using STRING database, and the core targets were speculated. The GO and KEGG enrichment analysis was conducted using R software. Autodock Vina software was used for molecular docking of ingredients and core targets. UC mice induced by dextran sodium sulfate(DSS) were treated by Baitouweng Decoction. The pathological changes of colon tissues were observed by HE staining, and the expression levels of related genes were analyzed by immunohistochemistry.The results showed that 26 active ingre-dients and 30 core targets were found in Baitouweng Decoction through network pharmacology. GO enrichment analysis showed that these genes mainly affected nuclear receptor activity, transcription factor activity, steroid hormone receptor activity, ubiquitin-like protein ligase binding, protein heterodimerization activity, transcription cofactor binding and other biological processes. KEGG enrichment analysis showed that P53 signaling pathway, EGFR signaling pathway, TNF signaling pathway, PI3 K-AKT signaling pathway and some cancer-related pathways were enriched. Molecular docking showed that EGFR, PPARG, CASP3, NOS3, caspase-9, CCND1, ADH, IL6 and NFKB1 were better docked with active ingredients. The experiments verified that Baitouweng Decoction could improve the colon pathology of mice, and EGFR is one of the related targets. Our study suggested that Baitouweng Decoction could treat UC through multiple targets and pathways, which provided a theoretical basis for future research.

Objective: To investigate the therapeutic effect of Jiawei Huangqin (JWHQ) decoction on ulcerative colitis (UC) and the regulation of STAT3/NF-kB/IL-6 pathway., Methods: Forty-eight mice were randomized into blank control group, model group, positive control (Sulfasalazine) group, and low-, moderate- and high-dose JWHQ Decoction groups ( n =8). In all but the blank control groups, the mice were given 3% DSS in drinking water to induce UC, followed 7 days later by treatment with saline (blank control and model groups) or JWHQ Decoction by gavage (10 mL/k) for 7 consecutive days. After the treatment, the mice were euthanized and the colon length was measured and the histopathological changes were observed with HE staining. The expression levels of STAT3, NF-κB, and IL-6 in the colon tissues were detected with RT-qPCR and Western blotting., Results: Compared with those in the blank control group, the colon length was significantly shortened and the pathological score of the colon tissue was significantly higher in all the other 5 groups ( P < 0.05). Compared with those in the model group, the colon length was significantly longer and the pathological scores were obviously reduced in all the 4 treatment groups ( P < 0.05). JWHQ Decoction at the high dose produced significantly better therapeutic effects than the positive drug in terms of the colon length ( P < 0.05) and the colon histopathological score ( P < 0.05); high-dose JWHQ Decoction also showed better effect than the other two doses ( P < 0.05), whose effects were comparable ( P > 0.05). The mouse models of UC showed significantly increased expression levels of STAT3, NF-κB, and IL-6 in the colon tissue ( P < 0.01), which were obviously lowered by the positive drug and JWHQ Decoction ( P < 0.01), especially at the high dose ( P < 0.01). JWHQ Decoction at the moderate dose produced similar effects with the positive drug on STAT3, NF-kB and IL-6 levels ( P > 0.05), and their effects were stronger than those of low-dose JWHQ Decoction ( P < 0.05)., Conclusions: JWHQ Decoction can improve UC in mice possibly by down-regulating the expression of STAT3, NF-kB and IL-6 in colonic tissue to affect the STAT3/NF-kB/IL-6 pathway.

Objective: To observe the efficacy of "Tongdu Tiaoshen" (dredging Governor Vessel and regula-ting mind,needling on the cognitive function of patients with sepsis associated encephalopathy (SAE)., Methods: A total of 64 patients with SAE were enrolled in the present study, and randomly and equally divided into a control group and a treatment group. Patients in the control group received conventional medicines and conventional needling treatment. The patients of the treatment group received conventional medicines and "Tongdu Tiaoshen" needling treatment. The treatment was conducted once daily for 10 days. The Montreal Cognitive Assessment (MoCA) scale was used to assess the therapeutic effect after the treatment. Serum interleukin-6 (IL-6) was detected by radioimmunoassay, serum C-reactive protein (CRP) was detected by immuno-scattering method, and arterial blood lactic acid (Lac) content was detected by blood gas analyzer., Results: The effective rate in the treatment group was obviously higher than that in the control group ( P < 0.01). After the treatment, the MoCA scores were considerably increased in both groups compared with their own pre-treatment ( P < 0.01), and the MoCA scores in the treatment group were obviously higher than those of the control group in the visual space and executive function, attention and computational power, language, abstraction and delayed recall dimensions ( P < 0.01). The contents of IL-6, CRP and Lac in both groups were significantly decreased after the treatment relevant to those of their own pre-treatment ( P < 0.01), and were obviously lower in the treatment group than those in the control group ( P < 0.01)., Conclusion: "Tongdu Tiaoshen" needling can significantly improve the cognitive function of SAE patients, which may be associated with its effect in reducing inflammatory reaction of sepsis.

Pyroptosis is a novel type of programmed cell death, which is closely related with the pathogenesis of myelodysplastic syndromes (MDS). The recent studies showed that all of S100A9/TLR4, S100A9/CD33 and Nox/ROS signaling pathways can activate oxygen-sensitivity NLRP3 inflammasome and then induce the pyroptosis of hematopoeitic stem cells (HSC) / hematopeitic pregenitor cells (HPC), resulting in ineffective hematopoiesis in patients with MDS. Further studies on the role and molecular mechanism of pyroptosis in the pathogenesis of MDS will provide the potential opportunity for the diagnosis and treatment of MDS. Here, the recent advances in the role and mechnism of pyroptosis in the pathogenesis of MDS are reviewed.

Ulcerative colitis (UC) is a chronic nonspecific inflammation mainly involving rectum and colon mucosa, which seriously affects the health and quality of life of patients, and is listed as one of modern refractory diseases by WHO. Professor XU Jing-fan, a great master of traditional Chinese medicine, has accumulated rich experiences in the treatment of UC. The study collected Professor XU's 77 prescriptions of treating UC, analyzed the frequency of traditional Chinese medicines and there categories, and investigated the medication regularity by the system clustering method. The findings showed that the most frequently used drugs were clearing-heat herbs, which were followed by hemostatic herbs, excreting-dampness herbs, improving-digestion herbs and tonifying-Qi herbs. At the same time, the commonly combined drugs were excavated. Finally, in order to analyze potential molecular targets of the frequently used herbs, GO enrichment analysis and KEGG signal pathway enrichment analysis were performed with bioinformatics analysis tool for molecular mechanism of traditional Chinese medicine (BATMAN-TCM). The results indicated that Chinese herbal compounds may treat UC by activating PPAR-γ pathway and regulating intestinal inflammation. The exact mechanisms shall be verified through subsequent molecular biological experiments., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Chinese Pharmaceutical Association.)

In order to better understand the hydrological process in Xilin River Basin, 248 water samples were collected in 13 sections (10 were at the mainstream and 3 were at the three tributaries) over the Xilin River during 2006-2008 and thereafter analyzed by high resolution inductively coupled plasma mass spectrometry (ICP-MS) for 20 trace elements. The temporal and spatial distribution characteristics of trace elements were obtained. The results showed that the average concentration values of trace elements were 0. 1-10 microg x L(-1). Most of those values were at the concentration ranges of precipitation and groundwater and very close to the values of groundwater, indicating that the surface water was recharged by precipitation and groundwater especially by groundwater. The variation of concentration of trace elements in surface water was not strong at the temporal scale. Usually, the concentration values of trace elements were higher in April and May than those in July and August while those values were a bit lower in 2007 than in 2006 and 2008. Most of the trace element concentrations showed a upward trend from upstream to downstream. The enrichment of trace elements was contributed to the recharge of tributaries and groundwater, the evaporation of the stream water.

To study the variations of deltaD and delta18O in precipitation, 301 samples were sampled during 2002-2004 in 6 sites in the Heihe River basin, Northwestern China. The deltaD and delta18O values ranged from 59 per thousand to -254 per thousand and 6.5 per thousand to -33.4 per thousand, respectively. This wide range indicated that stable isotopes in precipitation were controlled by different condensation mechanisms as a function of air temperature and varying sources of moisture. delta18O in precipitation had a close positive relationship with the air temperature, i. e., a clear temperature effect existed in this area. At a monthly scale, no precipitation effect existed. On the other hand, a weak precipitation effect still accrued at precipitation events scale. The spatial variation of delta18O showed that the weighted average delta18O values decreased with the increasing altitude of sampling sites at a gradient of -0. 47 per thousand/100m. A regional Meteoric Water Line, deltaD = 7.82 delta18O + 7.63, was nearly identical to the Meteoric Water Line in the Northern China. The results of backward trajectory of each precipitation day at Xishui showed that the moisture of the precipitation in cold season (October to March) mainly originated from the west while the moisture source was more complicated in warm season (April to September). The simulation of seasonal delta18O variation showed that the stable isotope composition of precipitation tended to a clear sine-wave seasonal variation.

Objective: To investigate the factors influencing the long-term survival of pancreatic carcinoma patients after radical resection., Methods: The data of 184 pancreatic carcinoma patients with radical resection were analyzed retrospectively. Analysis of the prognostic factors influencing the long-term survival was performed using Cox proportional hazard regression model., Results: The overall 1-, 3- and 5-year survival rates in this group were 61.7%, 29.0% and 14.3%, respectively. They were 78.0%, 38.4% and 25.7%, respectively, for the patients with a tumor < 3 cm in diameter, significantly better than those with a tumor >or= 3 cm (52.8%, 22.7% and 7.2%, respectively, P < 0.05). Moreover, the 1-, 3- and 5-year survival rates were 67.6%, 30.5% and 17.4%, respectively, in the patients without lymph node involvement, much longer than that in those with lymph node metastasis (37.1%, 20.6% and 0, respectively, P < 0.05). Multivariate analysis by Cox proportional hazard regression model revealed that the tumor size (P < 0.05) and lymph node metastasis (P < 0.01) significantly influenced the long-term survival of the patients., Conclusion: Tumor size and lymph node metastasis are significant factors influencing the long-term survival of pancreatic carcinoma patients with radical resection. Therefore, early diagnosis and radical resection are the key points to improve treatment outcome.