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Nursing clinical practice has changed dramatically in recent years due to advances in medical science. Increasing medical costs and the rising prevalence of chronic diseases in growing elderly populations have encouraged the development of various new case management care models. The purpose of this study was to introduce the current status and future development of case management and telehealth care as well as to challenge and guide nurses. Rather than turning a blind eye to new developments in information technology, we must use such to help nurses develop individualized and humanized care plans. New technologies can also assist nurses to deliver efficient and effective professional nursing care. Nurse case managers must increase competencies in assessment, critical thinking, evidence-practice, communication and negotiation, cooperation and problem solving. Case managers must practice independently while cooperating with other team members. The case manager is also a vanguard in the application of telehealth care in the nursing profession. Such professionals have a strong potential role to play in the future development of the nursing profession.