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High incidence and mortality rate of lung cancer is a serious health problem. Lung cancer screening can improve the chances of early detection and early surgical intervention of lung cancer. Currently, lung cancer screening participation rate in China is low and lung cancer screening services are underutilized. What factors influence the lung cancer screening behavior of our population is unclear. In this paper we summarize current status of research on factors influencing lung cancer screening behavior at home and abroad, and provide references to the development and implementation of lung cancer screening programs in China.

Objective: To summarize the imaging and clinical features of ovarian Sertoli–Leydig cell tumors (SLCT) to improve our understanding of the disease. Methods: The clinical and imaging data of 15 patients with SLCT confirmed by surgery and pathology were analyzed retrospectively. All patients underwent contrast-enhanced MRI, and five patients underwent contrast-enhanced CT. The expression levels of tumor markers and endocrine hormones were detected in 15 and 10 patients, respectively. Results: All 15 cases of SLCT were unilateral: 8 tumors in the left accessory and 7 tumors in the right accessory, and 4 solid tumors and 11 cystic solid tumors. MRI findings showed that solid components in masses were mainly indicated by intermediate intensity on T1WI and slight hyperintensity on T2WI, while cystic components were indicated by hypo-signal on T1WI and hyper-signal on T2WI. Solid components showed hyper-signals on DWI and hypo-signals on the ADC map. Four cases of solid tumors showed marked enhancement; all the solid components in five cases of cystic solid tumors showed marked enhancement, presenting as nodular, irregular septa, or cystic wall; and the other six cases of cystic solids showed mixed enhancement after administration of contrast medium. Among the six cases of mixed enhancement, five were moderately to poorly differentiated, and one was moderately differentiated. CT findings revealed that the solid components had soft tissue density, whereas cystic components had watery density. Three cases of solid tumors showed marked enhancement, while two cases of cystic solid tumors showed marked enhancement of the solid components or mixed enhancement. Nine patients had increased testosterone levels . Three patients had elevated AFP levels, two had elevated CA125 levels, and one had raised CA199 levels. Ten patients presented with androgen stimulation-related symptoms, two with estrogen stimulation-related symptoms, two with the co-action of estrogen and androgen and one without symptoms. Histopathological results showed that two cases were highly differentiated, seven were moderately differentiated, five were moderately to poorly differentiated, and one was poorly differentiated. Conclusion: SLCT presents as a solid or cystic solid mass, and solid components show either marked or mixed enhancement. Patients with moderate-to-poor and poor differentiation may present with mixed enhancement. SLCT often presents with symptoms related to stimulation of hormones, most commonly androgen.

The southwestern China is a vital ecological safeguard and is characterized by ecological fragility and climate sensitivity.Based on the MOD13A3 NDVI dataset， this study used a pixel dichotomy model to calculate the average Fractional Vegetation Cover （FVC） from 2000 to 2020 annually， during growing seasons， and in each of the four seasons for the whole southwestern China and its provinces， a spatio-temporal variation analysis was then performed on FVC across different time scales.The study also discussed the primary factors influencing FVC changes over the past 21 years， using ERA5 temperature data， GPCP satellite precipitation data， and DEM data.Finally， the Hurst Index was used to predict future FVC trends.（1） The results indicate that from 2000 to 2020， the overall FVC in the eastern part of the southwestern China showed an increasing trend， particularly in Chongqing and Guizhou， while Tibet showed a general decline.（2） Spatially， the FVC generally showed a "higher in the east and lower in the west" trend， with areas where FVC increased accounting for 43.9% of the total area， and areas of decrease accounting for 53.5%.（3） Precipitation promotes FVC， while temperature has varied effects in different regions.（4） Human activity significantly impacts FVC， with promotion， suppression， and no effect zones accounting for 40.4%， 47.6%， and 12.0% of the grid percentage， respectively.（5） Elevation and FVC over different time scales are significantly correlated but both exhibit a pronounced declining trend.FVC increases significantly with slope， but decreases when the slope is greater than 25°.The effect of aspect on FVC in the southwestern China is less significant than that of slope， elevation， and climatic factors.（6） In the future， the FVC in Tibet and the eastern parts of Sichuan， Yunnan， and Guizhou in the southwestern China will increase， while most areas of western Sichuan and the Hengduan Mountains will exhibit a decreasing trend.The results can provide data support and scientific guidance for the formulation of ecological protection plans in the southwestern China.

ObjectiveTo examine the prevalence and influencing factors of physician-diagnosed allergic rhinitis and parent-reported rhinitis-related symptoms among preschool children in Urumqi city, Xinjiang Uygur Autonomous Region for providing evidence to the prevention and control of the illness in the children. MethodsA self-administered survey was conducted among 10 000 children aged 2 – 7 years in 60 kindergartens selected with stratified random cluster sampling in Urumqi city during August – December 2019. A questionnaire was designed based on the International Study of Asthma and Allergies in Childhood (ISAAC) and Dampness in Buildings and Health (DBH) and the questionnaire was answered by the children's parents or guardians. The data collected were analyzed using SPSS 26.0. ResultsOf the 8 153 preschool children with valid information, 7.6% were reported having been diagnosed as allergic rhinitis and 27.4% ever having experienced rhinitis-related symptoms. The results of unconditional multivariate logistic regression analysis showed that the children with following characteristics were more likely to have allergic rhinitis: at elder age (5 – 7 year vs. 2 years: odds ratio[OR] = 1.36, 95% confidence interval [95%CI]: 1.04 – 1.80), being only child (OR = 1.24, 95%CI: 1.04 – 1.48), being born by cesarean section (versus vaginal delivery: OR = 1.21, 95%CI: 1.02 – 1.44), paternal history of rhinitis (OR = 2.50, 95% CI: 2.10 – 2.98), maternal history of rhinitis (OR = 3.29, 95%CI: 2.76 – 3.91), paternal history of asthma (OR = 1.95, 95%CI: 1.02 – 3.74), with larger living space ( ≥ 75 m2 vs. < 75 m2: OR = 1.25, 95%CI: 1.01 – 1.56), maternal exposure to new furniture at home during pregnancy (OR = 1.79, 95%CI:1.28 – 2.51), and having indoor decoration at home at the age of 0 – 1 year (OR = 1. 82, 95%CI: 1.19 – 2.79) ; while the children being girl (OR = 0.79, 95%CI: 0.67 – 0.94) and living in a house with lime/cement as wallcovering (versus wallpaper: OR = 0.39, 95%CI: 0.16 – 0.98) were less likely to have allergic rhinitis; the results also revealed significant influencing factors of rhinitis-related symptoms as following: being only child (OR = 1.22, 95%CI: 1.10 – 1.36), being born by cesarean section (versus vaginal delivery: OR = 1.14, 95%CI: 1.02 – 1.26), paternal history of rhinitis (OR = 2.16, 95% CI: 1.93 – 2.42), maternal history of rhinitis (OR = 2.38, 95%CI: 2.13 – 2.67), paternal history of asthma (OR = 2.22, 95%CI: 1.34 – 3.69), living in a house with the floor covered by composite material (versus wood: OR = 1.53, 95%CI: 1.28 – 1.84) or tile/stone/cement (versus wood: OR = 1.28, 95%CI: 1.11 – 1.49 ), maternal exposure to new furniture at home during pregnancy (OR = 1.28, 95%CI: 1.03 – 1.60), with beddings being aired in sunny day frequently (OR = 1.42, 95%CI: 1.18 – 1.71), and with indoor cultivation of flowering plant at home at the age of 0 – 1 year (OR = 1.27, 95%CI: 1.11 – 1.46) and protective factors including being girl (OR = 0.87, 95%CI: 0.78 – 0.96), longer duration of exclusive breastfeeding (≥ 6 months vs. < 6 months: OR = 0.86, 95%CI: 0.77 – 0.96), and living in a house with material other than water based paint/emulsion paint/oily paint/board/lime/cement/seaweed mud as wallcovering (versus wallpaper: OR = 0.43, 95%CI: 0.29 – 0.64). ConclusionAmong preschool children in Urumqi city, the prevalence of allergic rhinitis and rhinitis-related symptoms were relatively high and mainly influenced by genetic factors and residential indoor environment.

In recent years, with the continuous improvement of medical level, people pay more attention to their own health, pulmonary nodules and other space-occupying lesions can be detected earlier, but on a global scale, the number of deaths caused by malignant lung lesions Still rising and remaining high. Radiomics is an emerging field that aims to derive automated quantitative imaging features from medical images to noninvasively predict nodular and tumor behavior. Compared with traditional visual image features, radiomics can extract more nodular features with better reproducibility. The scientific and systematic use of radiomics can not only prevent excessive medical behaviors and reduce the economic burden of patients, but also enable patients with lung lesions to receive early treatment for the best prognosis.

In order to investigate the correlation of bacterial community structure and biogenic amines in sufu, Illumina Miseq high-throughput sequencing was used to analyze the bacterial community structure of sufu with different biogenic amines content and relevant environmental factors were determined. The results showed that Firmicutes, Proteobacteria, Actinobacteria and Bacteroidetes were the absolute dominant phyla and the relative abundance of the four phyla were more than 91% in sufu samples. Bacillus, Weissella, Tetragenococcus, and Pseudomonas were the main dominant genera in sufu. The main different genera between high and low biogenic amines content groups were Bacillus, Weissella, Pseudomonas and Lysinibacillus. Correlation analysis showed that biogenic amines and total acid were the main factors affecting bacterial community composition (P

In order to make full use of the spatial detail information of remote sensing images, a remote sensing image fusion method based on convolution sparse representation and non-subsampled contourlet transform (NSCT) was proposed. First, the convolution sparse representation is used to establish a model to complete the super-resolution of image and achieve the purpose of detail enhancement. Then, the two images are fused, and the super-resolution image and panchromatic image are subjected to NSCT transformation to obtain their respective high-resolution sub-band images and low-resolution sub-band images. Appropriate methods are adopted according to the characteristics of different sub-bands. The new sub-band information is obtained by the fusion rules, and finally the NSCT inverse transform is performed to obtain fusion result. Experiments proved that the fusion image obtained by this method is superior to these of other methods in both visual effects and objective indicators.

The biogenic amine Level in Jiangxi-made sufu was analyzed by high performance liquid chromatography (HPLC) and amine-producing bacteria were isolated and identified by microbiological methods combined with HPLC confirmation. The results showed that total biogenic amine level ranged from 68.5 to 1084.0 mg/kg in sufu samples. Major biogenic amines were tryptamine, putrescine, histamine and tyramine, among which putrescine and tyramine were of the highest level. Biogenic amine level produced by 9 amine-producing bacteria ranged from 93.8 to 369.2 mg/L. For six bacteria with relatively high amine productivity, phenotype and genotype 16S rDNA sequence determination had found one Bacillus sporothermodurans strain, one Rummeliibacillus stabekisii strain, three Lysinacillus boronitolerans strains and one Staphylococcus piscifermentans strain. The current research offered theoretical evidence for edible safety evaluation of sufu and served as research basis to investigate how to inhibit activity of amine-producing bacteria in sufu.

本文介绍了1例基于基因检测的后循环缺血介入治疗后抗血小板治疗的患者情况。该例患者为老年女性，基底动脉中段闭塞所致急性缺血性卒中，发病3 h内入院，给予静脉溶栓后桥接介入治疗，治疗后恢复较好（NIHSS评分从入院时的11分降至出院时的2分）。为个体化选择患者的抗血小板治疗方案，在介入治疗后进行细胞色素P450酶家族2亚家族C成员19（cytochrome P450 family 2 subfamily C member 19，CYP2C19）基因检测，显示为中间代谢型，提示患者可能存在氯吡格雷抵抗，选择替格瑞洛联合阿司匹林双联抗血小板方案进行3个月的抗血小板治疗，之后根据患者随访情况调整用药。出院后2个月随访时患者预后良好且未出现出血表现。 Abstract: This article described a case of a patient with antiplatelet therapy after interventional therapy for posterior circulation ischemia based on gene detection. The patient was an elderly female with acute ischemic stroke caused by middle segment occlusion of the basilar artery. She was admitted within 3 hours of onset and received intravenous thrombolysis followed by bridging interventional therapy. After treatment, the patient recovered well (NIHSS score decreased from 11 points at admission to 2 points at discharge). In order to individualize the selection of the patient’s antiplatelet therapy regimen, cytochrome P450 family 2 subfamily C member 19 (CYP2C19) gene detection was performed after interventional therapy, which showed an intermediate metabolism type, indicating that the patient may have clopidogrel resistance. Therefore, the dual antiplatelet therapy regimen of ticagrelor combined with aspirin was selected for 3 months for antiplatelet therapy, and then the medication was adjusted according to the patient’s follow-up. At two months of follow-up after discharge, the prognosis was good and there were no bleeding manifestations.

With nuclear magnetic resonance (NMR) and micrometer-nanometer CT Scanning technology, quantitative research was carried out of the micro-existing state of tight oil in the Chang7 Member of the Triassic Yanchang Formation in the Ordos Basin. The total reserves of the tight oil in the reservoirs were determined using NMR technology. The initial oil saturation was measured as 63.99%. The 2-D slice images of the tight oil reservoirs were obtained using CT Scanning technology, and the 3-D images were acquired after digital synthesis processing. Accordingly, the existence states of the tight oil in the reservoirs are divided into six types, namely thin film form, cluster form, throat form, emulsion form, particle form and isolation form. It is found by quantitative calculation of the contents of tight oil in different existence states of tight oil that the emulsion form and thin film form are the main existence states, which account for 70% of the total amount of the tight oil in the reservoirs, followed by the cluster and particle forms. The contents of isolation form and throat form tight oil are low. The contents of tight oil in various existence states are related to initial water saturation, clay mineral content and pores structure of the reservoirs. Key words: tight oil, microscopic state, quantitative research, Ordos Basin, Triassic Yanchang Formation

In order to explore the application value of different grape varieties in fruit beer brewing and their effects on beer quality, we studied the effects of addition of different levels (30% and 40%, V/V) of Syrah or Merlot grape mashes on the aroma, physical and chemical indexes and antioxidant activity of fruit beer. Besides, grape beer with better quality was determined by sensory evaluation. The results showed that both grape varieties increased the concentration and antioxidant properties of phenols including 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging capacity, ferric and cupric ion reducing power abilities, and significantly elevated the acidity and alcohol concentration of beer. The beer made with the addition of 30% Syrah or 40% (V/V) Merlot exhibited the highest content of aroma compounds, which increased by 190.55% and 152.65%, respectively, when compared with the control group. Sensory evaluation showed that the beer made with the addition of 30% Syrah tasted best. In general, the addition of different varieties of grape mashes had a positive effect on improving beer quality and aroma, which could become an important direction for the development of diversified beer products in the future.

Accurate prediction of pollutants in grain processing is of great significance to ensure food safety. However, due to the complexity of grain processing and the difficulty of pollutant detection, the data volume is too small to meet the needs of modeling and forecasting, so it is necessary to develop a method for expanding pollutant data from small samples. At the same time, pollutant data of small samples in grain processing often lacks sufficient prior knowledge. Traditional supervised learning method has low prediction accuracy, and the existing continuous deep learning model is not suitable for grain processing, being intermittent. Hence, there is a need to develop a prediction method based on unsupervised learning and deep learning for pollutants in grain processing. This study proposed a prediction method for pollutants in grain processing based on data expansion with time generative adversarial networks (TimeGAN) or based on generative adversarial networks (GAN) combined with deep forest (DF). First, a TimeGAN model was constructed to learn from small sample data and generate multiple sets of sample data, achieving data augmentation. Then, combining the GAN model with unsupervised learning with the DF model suitable for a discrete process, a GAN-DF model was constructed for pollutant prediction. Next, the DF and long short-term memory (LSTM)-DF models were embedded into GAN as generators, separately, and the resulting DFGAN and LSTM-DFGAN models had improved accuracy in pollutant prediction. The results of simulation and verification using the data of the heavy metal pollutant lead (Pb) in rice processing showed that the TimeGAN method was feasible to expand data, and the LSTM-DFGAN model had the best comprehensive prediction performance. After data expansion, the average absolute error and root mean square error were as low as 7.50 × 10-5 and 1.60 × 10-8 mg/kg, respectively.

Iron deficiency anemia (IDA) is a common iron deficiency disease. IDA has become one of the major public health problems worldwide. Our previous studies have shown that Auricularia auricula melanin (AAM) can alleviate IDA, but the mechanism is not clear. In this study, the role of the intestinal microflora in the improvement of IDA by AAM was studied by elimination of gut bacteria using an antibiotic cocktail as well as using metabonomics. The results showed that AAM treatment significantly alleviated anemia symptoms of IDA mice in terms of body mass, hemoglobin concentration, hematocrit, mean erythrocyte volume and platelet count, and this effect was lost when the intestinal flora was eliminated. Totally 76 differential metabolites were identified by metabolnomics analysis. Pathway enrichment analysis identified seven pathways including tryptophan metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, ascorbic and uronic metabolism, glutathione metabolism, tyrosine metabolism, pentose and glucuronate interconversion and steroid hormone biosynthesis. Among these, tryptophan metabolism was most significant. In the presence of intestinal microflora, tryptophan metabolites such as 5-hydroxyindole acetic acid and N-formyl kynurenine were significantly accumulated in IDA mice supplemented with AAM, indicating that AAM could mitigate IDA, which may be related to activation of tryptophan metabolism through the intestinal flora. This study may provides a theoretical basis for further research on the mechanisms by which AAM improves IDA and for the development of anti-IDA products.