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Aiming at the problem that most current researches on text semantic communication mainly rely on simulation system for theoretical verification, an extensible hierarchical semantic communication system was proposed by taking advantage of the separation of hierarchical encoding and decoding architecture in semantic level and grammatical level.The system was compatible with the reliable communication technology under the framework of Shannon information through the mode of semantic and syntactic separation, and realized the nested combination of semantic communication and traditional communication.Furthermore, a universal and extensible verification system was built based on the software radio platform to verify the proposed semantic communication system architecture.The verification system took semantic communication software platform as the driving core of hardware drive and algorithm call, integrated the whole process of signal generation, information transmission, data acquisition, decoding and evaluation at the receiving end, and could be further extended for semantic and syntactic level.Finally, the text semantic communication was tested based on this verification system, which verified that it had higher validity and reliability than the traditional communication mode.

A communication system based on extended contextual semantic features was proposed by using an end-to-end integrated design method based on deep learning.Unlike existing research that focused only on local context while neglecting global context, the proposed system integrated both local and global contextual knowledge, semantic encoding and decoding was utilized by extended contextual knowledge, thereby enhancing the reliability of the semantic communication system.At the transmitter, efficient semantic representation was achieved through extended contextual semantic encoding.At the receiver, the accuracy of semantic inference was improved by combining mechanisms such as historical communication text mining, contextual semantic feature learning, and heuristic graph-based decoding strategy.When comparing with the traditional communication system and the existing semantic communication systems, simulation results demonstrate that the proposed system significantly improves the reliability of the communication system under low signal-to-noise ratio.

Doxorubicin is a broad-spectrum chemotherapy drug commonly used in clinical practice. Improving the delivery efficiency of doxorubicin can help improve the therapeutic effect of tumor and reduce the corresponding side effects. The delivery of doxorubicin based on nano-drug loading technology can provide important help for targeted killing of tumor cells. Tumor development is usually accompanied by the changes in the stiffness of extracellular matrix. The effect of substrate stiffness on the endocytic behavior of doxorubicin based on drug-loading nanoparticle technology was explored by the cellular activity regulated by doxorubicin endocytosis and the changes in the expression of important proteins associated with endocytosis. The substrate stiffness can be regulated by adjusting the ratio of PDMS binder and curing agent. The results of the experiment showed that the cell activity on the substrate with appropriate stiffness (Young's modulus of 0.578, 0.815 and 1.986 MPa) was inhibited, indicating that the transport of doxorubicin was more efficient in this range of substrate stiffness. To explore the underlying mechanism of substrate stiffness regulation of doxorubicin endocytosis, we explored the expression of αVβ5 and NUMB, which are closely related to the endocytosis process. From the results of immunofluorescence protein and Western blot experiments, the fluorescence intensity of the αVβ5 protein responsible for anchoring clathrin on the substrate with a Young's modulus of 1.986 MPa was the highest; Within the appropriate stiffness range, the fluorescence intensity of NUMB protein was significantly increased, indicating that increased expression of NUMB and αVβ5 regulated by substrate stiffness mediates doxorubicin transport, thereby affecting cell viability. This work provides a reference for further improving the efficacy of chemotherapy drugs in the treatment of tumors.