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Objective To investigate risk factors for short-term major adverse cardiovascular events (MACE) following percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) with type 2 diabetes mellitus (T2DM). Methods We retrospectively analyzed the clinical data of 147 patients with AMI with T2DM who underwent PCI in Kaifeng people’s Hospital from August 2016 to January 2020 as well as their information on MACE within 3 months after PCI. The patients were divided into MACE group and normal group according to whether MACE occurred or not within 3 months after operation. The two groups were compared in terms of blood glucose variability [standard deviation of blood glucose (SDBG), mean amplitude of glycemic excursions (MAGE), absolute mean of daily differences (MODD), and postprandial glucose excursions (PPGE)] within 72 h after operation as well as total cholesterol (TC), high-sensitivity C-reactive protein (hs-CRP), and left ventricular ejection fraction (LVEF) after operation. The risk factors for the occurrence of MACE were analyzed. Results The incidence of MACE within 3 months after PCI was 23.81%. The MACE group showed significantly higher levels of SDBG, MAGE, MODD, and PPGE within 72 h after operation and a significantly higher hs-CRP level after operation (t=10.206-24.388,P

Using metakaolin and water glass as raw materials, the influence of H2O/Na2O, Na2O/Al2O3 and ultrasonic action on the compressive strength of geopolymers were investigated, and the regulation of pore structure by H2O/Na2O, cetyltrimethylammonium bromide (CTAB) and ultrasonic action was discussed by nitrogen adsorption method. The results show that with the increase of H2O/Na2O, the compressive strength of geopolymer decreases gradually, but it is beneficial to form large pores. With the increase of Na2O/Al2O3, the compressive strength first increases and then decreases. The closer the initial time of ultrasound is to the final setting time, the lower the compressive strength is. The addition of CTAB is conducive to the formation of 3~5 nm pores. Compared with the samples with the later ultrasonic starting time, the ultrasonic action will reduce the large pores around 120 nm when the slurry is 1/2 of the initial setting time, and the longer the ultrasonic duration, the more pores of the gel at 3~5 nm. With the synergistic effect of ultrasound and CTAB, the number of mesopores about 40 nm and large pores about 120 nm appear and the pore shape is mostly cylindrical. [ABSTRACT FROM AUTHOR]

Water absorption is one of the most important factors which can induce serious rock deformation and failure. Water vapor absorption experiments were carried out on rock samples collected from three different coal mines. Meanwhile, the mineral components, microstructure features and pore structure parameters were determined by means of X-ray diffraction, scanning electron microscopy and mercury intrusion porosimetry in order to comprehensively analyse the effects of clay minerals and micropore structure on water vapor absorption of the investigated rock samples. Results have shown that the patterns of the water vapor absorption curves of the three types of rocks were all characterized by a similar kind of dynamic process with decreasing water vapor absorption rate which could be well fitted by a negative exponential function. However, significant differences were found in water vapor absorption ability among the three types of rock samples which could be sorted in an order of Daqiang conglomerate > Shajihai mudstone > Halagou sandstone. Furthermore, the greater abundance of clay minerals contained in rock samples, especially smectite, the more and quicker water vapor absorption. Meanwhile, water vapor absorption is positively correlated with effective porosity, but is negatively correlated with fractional dimension which indicates that the bigger the effective porosity the greater the water vapor absorption ability and the more complicated the pore structures the weaker the water vapor absorption ability.

Objective: To report on the diagnosis and treatment process and clinical characteristics of a child with disorder of sex development (DSD) and to conduct pathological, imaging and genetic analysis for the patient., Methods: Clinical data of the patient were collected. Genetic testing including chromosomal karyotyping, fluorescence in situ hybridization (FISH), copy number variations (CNVs) analysis, SRY gene detection and multiple ligation-dependent probe amplification (MLPA) were carried out., Results: The patient had a social gender of male, with a history of hypospadia and breast development. Sex hormone tests showed slightly raised prolactin. Imaging results showed bilateral breast hyperplasia, abnormal seminal vesicle glands, rudimentary uterus, and underdeveloped right testis. Intraoperative examination revealed that the child had an ovary on the left and a testis on the right. The pathological results showed fibroadenomatoid changes in the breast. The patient had a karyotype of 46,XX. FISH results showed 46,XX.ish(DXZ1x2, SRYx0). Molecular testing showed that NR0B1, PHEX, CXORF21, GJB1, PQBP1, and COL4A5 genes are duplicated. There was a presence of SRY gene and absence of UYT gene., Conclusion: DSD should be considered in patients with genital abnormality and male breast development. Ultrasound, sex hormone test and genetic testing should be performed to confirm the diagnosis of DSD, and molecular testing should be performed if necessary. Individualized treatment of DSD patient requires cooperation of multiple clinical disciplines.

Objective: To explore the genetic basis for an infant with neonatal diabetes (NDM) and multiple malformations., Methods: Genetic variants were detected by next generation sequencing (NGS). Suspected variant was verified by Sanger sequencing., Results: A de novo heterozygous variant, c.1454_1455del(p.K485Rfs), was detected in exon 5 of the GATA6 gene. The variant was undetected in his parents and unreported previously. Bioinformatic analysis predicted the variant to be pathogenic., Conclusion: The heterozygous variant of c.1454_1455del(p.K485Rfs) of the GATA6 gene probably underlies the disease in this child. Genetic testing can facilitate diagnosis and genetic counseling for NDM.