8 results on '"Zhang, Jinli"'
Search Results
2. Expression Recognition and Interaction of Pharyngeal Swab Collection Robot.
- Author
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GUO Xinwei, MA Nan, LIU Weifeng, SUN Fuchun, ZHANG Jinli, CHEN Yang, and ZHANG Guoping
- Subjects
FACIAL expression ,SELF-expression ,FEATURE extraction ,ROBOTS ,PROBLEM solving ,HUMAN-robot interaction - Abstract
The recognition of the facial expression of the collected person of pharyngeal swabs, and the interactive control of the human emotional expression have important significance for the successful collection of pharyngeal swabs of the pharyngeal swab collection robot. When training the data sampled by the throat swab robot, there are some problems, such as the expansion of occlusion removal and micro- expression recognition, the definition of self- collected data sets, key frame recognition and processing, expression classification and delimitation, and interactive integration. To solve these problems, it proposes an effective framework named efficient self-cured network (ESCN). First, a weighted feature extraction model with the ability to recognize faces is constructed. Second, the subjects are captured by a multi-scale attention mechanism. Finally, the facial expressions of throat swab collectors are identified by a relabel-corrected linear aggregation model. Experiments are validated on real datasets RAF-DB, FER2013 and self-collected datasets. The experimental results show that the accuracy of ESCN is 4.643~11.058 percentage points higher than the classic model. The parameter amount is relatively small, which is convenient for lightweight and integration. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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- View/download PDF
3. Repair effects of rat adipose-derived stem cells on DNA damage induced by ultraviolet in chondrocytes.
- Author
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ZHANG Jinli, LIU Zhihe, TANG Wenbin, XIONG Xifeng, ZHANG Zhi, CAO Wenjuan, and LI Xiaojian
- Published
- 2017
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4. Clinical practice of multi - sensory awakening nursing mode applied on postoperative coma patients with hypertensive cerebral hemorrhage.
- Author
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Zhang Jinli and Lu Kai
- Published
- 2018
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5. Development and application of nursing management function of integrated nursing station.
- Author
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Zhang Jinli, Xu Xiaoxin, and He Yuping
- Published
- 2014
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6. [Inhibitory effects of Kukoamine B on the inflammatory response of small intestine in lipopolysaccharide-induced septic mice and its potential mechanisms].
- Author
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Lyu W, Qin W, Zhang J, Shen W, Wang X, and Sun B
- Subjects
- Animals, Cytokines, Disease Models, Animal, Intercellular Adhesion Molecule-1, Interleukin-1beta, Intestine, Small metabolism, Lipopolysaccharides administration & dosage, Male, Mice, Mice, Inbred ICR, NF-kappa B, Nitric Oxide Synthase Type II, RNA, Messenger, Sepsis chemically induced, Signal Transduction, Spermine pharmacology, Toll-Like Receptor 4, Tumor Necrosis Factor-alpha, Caffeic Acids pharmacology, Intestine, Small drug effects, Sepsis drug therapy, Spermine analogs & derivatives
- Abstract
Objective: To study the role of Kukoamine B (KB) in inhibiting the inflammatory response of small intestine in septic mice and its molecular mechanisms., Methods: Twenty-four male ICR mice were randomly divided into control group, model group, and KB intervention group (each, n = 8). Sepsis model was reproduced by intra-peritoneal injection of 20 mg/kg lipopolysaccharide (LPS), while equivalent normal saline was given in control group, and 20 μg/kg KB was injected through caudal vein 4 hours after LPS challenge in KB intervention group. The blood/tissue samples (jejunum and ileum) were harvested 8 hours after LPS injection. The levels of plasma LPS, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were measured. The pathological changes in small intestine tissues were observed under light microscope, while the levels of inflammatory cytokines TNF-α and IL-1β in the tissue homogenates (jejunum and ileum) were assessed by enzyme linked immunosorbent assay (ELISA). The activity of myeloperoxidase (MPO) was measured by colorimetry. The expression of intercellular adhesion molecule-1 (ICAM-1) was determined by immunohistochemistry. The expressions of inducible nitric oxide synthase (iNOS) mRNA was assayed by reverse transcription-polymerase chain reaction (RT-PCR). The activation of nuclear factor-Κβ (NF-Κβ) was determined by Western Blot., Results: The mice in model group were found to have an increase in microvascular permeability, interstitial edema, and infiltration of white blood cells, and the levels of LPS, TNF-α and IL-1β in their plasma, with an increase in concentrations of TNF-α and IL-1β, activity of MPO, positive expression of ICAM-1, expression of iNOS mRNA and NF-ΚB protein in small intestine (jejunum and ileum). Compared with model group, in mice with KB intervention, microvascular permeability, interstitial edema, and infiltration of white blood cells were reduced significantly, while the levels of LPS, TNF-α and IL-1β in plasma, the concentration of TNF-α and IL-1β, the activity of MPO, the positive expression of ICAM-1, the expression of iNOS mRNA and NF-ΚB protein in small intestine (jejunum and ileum) were significantly decreased [plasma LPS (kEU/L): 654.09±28.13 vs. 1 155.65±47.15, TNF-α (ng/L): 12.75±0.47 vs. 30.61±0.71, IL-1β (ng/L): 53.06±5.32 vs. 64.47±2.61; jejunum TNF-α (ng/L): 43.27±1.20 vs. 64.82±2.09, IL-1β (ng/L): 326.38±14.47 vs. 535.22±13.48, MPO (U/g): 0.14±0.01 vs. 0.32±0.02, iNOS mRNA (2(-ΔΔCt)): 2.39±0.13 vs. 10.80±0.22, NF-ΚB protein (gray value): 0.687±0.062 vs. 1.404±0.046; ileum TNF-α (ng/L): 62.75±3.92 vs. 104.24±2.82, IL-1β(ng/L): 408.06±1.70 vs. 521.97±1.16, MPO (U/g): 0.36±0.08 vs. 0.66±0.05, iNOS mRNA (2(-ΔΔCt)): 1.65±0.11 vs. 3.59±0.29, NF-ΚB protein (gray value): 0.830±0.114 vs. 1.609±0.051, all P <0.05]., Conclusions: KB can combine with LPS and inhibit LPS/Toll-like receptor 4 (TLR4) signaling pathway, thereby significantly inhibit the inflammatory response and protect the function of the small intestine in LPS-induced septic mice.
- Published
- 2015
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7. [Inhibitory effect of kukoamine B on lung inflammatory responses in mice with sepsis].
- Author
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Zhang J, Qin W, Lyu W, Shen W, Wang X, and Sun B
- Subjects
- Animals, Disease Models, Animal, Interleukin-1beta metabolism, Lung drug effects, Lung metabolism, Lung pathology, Male, Mice, Mice, Inbred ICR, NF-kappa B metabolism, Nitric Oxide Synthase Type II metabolism, Peroxidase metabolism, Sepsis metabolism, Sepsis pathology, Spermine pharmacology, Tumor Necrosis Factor-alpha metabolism, Caffeic Acids pharmacology, Sepsis drug therapy, Spermine analogs & derivatives
- Abstract
Objective: To investigate the inhibitory effect of kukoamine B (KB) on lung inflammatory responses in mice with sepsis and its possible molecular mechanism., Methods: Twenty-eight male mice were randomly divided into control group (n=8), lipopolysaccharide (LPS) group (n=10), and LPS + KB group (n=10). Sepsis model was reproduced by intra-peritoneal injection of 20 mg/kg LPS, while equivalent normal saline was given in control group, and 20 μg/kg KB was injected through caudal vein 4 hours after LPS challenge in LPS + KB group. After 8 hours of LPS challenge, the concentration of LPS in plasma and the activity of myeloperoxidase (MPO) in the lung tissue were determined. The contents of tumor necrosis factor-α (TNF-α) and interleukin-1β(IL-1β) in plasma, alveolar lavage fluid and lung tissue homogenates were assessed by enzyme linked immunosorbent assay (ELISA). The activation of nuclear factor-ΚB (NF-ΚB) and the expression of inducible nitric oxide synthase (iNOS) in lung tissue were determined by Western Blot. The pathological changes in lung tissues were observed with hematoxylin-eosin (HE) staining. The expression of intercellular adhesion molecule-1 (ICAM-1) in lung tissue was determined by immunohistochemistry., Results: Compared with control group, the concentration of LPS in plasma (1 155.650±147.149 kEU/L vs. 31.390±18.859 kEU/L), MPO activity (1.177±0.093 U/g vs. 0.775±0.166 U/g), NF-ΚB activity (gray value: 1.557±0.105 vs. 0.824±0.032) and the expression of iNOS (gray value: 0.650±0.129 vs. 0.392±0.097) were significantly increased in LPS group (all P<0.05). After KB intervention, the concentration of LPS (624.461±149.012 kEU/L), MPO activity (0.919±0.023 U/g), NF-ΚB activity (1.127±0.074) and the expression of iNOS (0.425±0.066) were significantly lowered (all P<0.05). Compared with control group, the contents of TNF-α (47.325±13.864 ng/L vs. 6.534±0.544 ng/L, 13.382±2.231 ng/L vs. 3.748±0.692 ng/L, 31.127±7.399 ng/L vs. 14.948±4.673 ng/L) and IL-1β (74.329±11.890 ng/L vs. 29.921±6.487 ng/L, 9.422±2.674 ng/L vs. 1.105±0.364 ng/L, 528.509±32.073 ng/L vs. 109.945±13.561 ng/L) in plasma, alveolar lavage fluid and lung tissue homogenates were obviously enhanced in LPS group (all P<0.05). With KB intervention, the contents of TNF-α (20.331±7.789 ng/L, 7.145±1.202 ng/L, 15.966±2.946 ng/L) and IL-1β (57.707±8.098 ng/L, 2.212±0.878 ng/L, 426.154±11.270 ng/L) were markedly reduced (plasma TNF-α: F=16.052, P=0.002; IL-1β: F=20.649, P=0.000; lung tissue homogenates TNF-α: F=31.134, P=0.001; IL-1β: F=22.792, P=0.002; alveolar lavage fluid TNF-α: F=10.013, P=0.009; IL-1β: F=319.857, P=0.000). In addition, leukocyte infiltration to the lung tissue was attenuated, and the expression of ICAM-1 was reduced by KB in histological examination., Conclusions: KB, as a neutralizer of LPS, can inhibit the release of inflammatory mediators, reduce the pulmonary inflammatory response and protect the function of lung in septic mice.
- Published
- 2014
- Full Text
- View/download PDF
8. [The coagulation factor VII gene polymorphisms in patients with myocardial infarction in Ningxia Hui and Han populations].
- Author
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Huang H, Jia S, Chen S, Sha Y, Ma A, Ma X, Zhang J, Bai X, and He L
- Subjects
- Aged, Asian People ethnology, Case-Control Studies, Factor VII metabolism, Female, Humans, Male, Middle Aged, Myocardial Infarction metabolism, Asian People genetics, Factor VII genetics, Myocardial Infarction ethnology, Myocardial Infarction genetics, Polymorphism, Genetic
- Abstract
Objective: To investigate the characteristics for activated coagulation factor VII(F VIIa) and the R353Q, -323 0/10 bp, HVR4 polymorphisms in the gene in patients with coronary heart disease (CHD) and myocardial infarction from Ningxia Hui and Han populations., Methods: Four hundred and twenty angiographically proven CHD patients in the Hui population, and 508 healthy blood donors were tested for their plasma levels of coagulation factor VII using recombinant tissue factor method. The coagulation factor VII gene R353Q, -323 0/10 bp and HVR4 genotypes were identified by polymerase chain reaction. In addition, 600 Han patients with CHD and 604 healthy Han control subjects were also investigated., Results: (1) The plasma F VIIa levels was significantly higher in patients with CHD and myocardial infarction than that in healthy control subjects and angor pectoris (P<0.01) in both Hui and Han populations. (2) There were significant differences in the distribution of genotypes and allelic frequencies of the R353Q between myocardial infarction and angor pectoris disease in the Hui population (P<0.05). So was the -323 0/10 bp locus in both the Hui and Han population. (3) The F VIIa level was significantly higher in individuals with RR genotype than those of Q allele carriers in the Hui population., Conclusion: There are polymorphisms of the F VII gene R353Q, -323 0/10 bp and HVR4 in the Hui and Han populations. The Q allele might be a protective factor against myocardial infarction in the Hui, and the plasma F VIIa level may be influenced by the R353Q polymorphism of the F VII gene. The 10 allele may be a protective factor against myocardial infarction in both the Hui and Han populations.
- Published
- 2009
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