1. Study on the synthesis and synergistic antibacterial effects of PDA@Ag-amoxicillin composite material.
- Author
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QIU Ying, LIANG Ben, YANG Junpeng, DING Chao, ZHANG Lijun, MU Chengqian, WANG Jiawei, GUO Shaobo, SONG Fengmin, SHI Juan, and ZHANG Tianlei
- Abstract
Owing to the inappropriate use of antimicrobial agents and the process of natural selection of microorganisms, antibiotic resistance has become a serious problem that challenges the health of human beings. Integrating two different bactericidal agents into one matrix is a feasible approach to enhance antibacterial efficiency. This study synthesized an efficient antibacterial nanocomposite material by conjugating polydopamine-modified silver nanoparticles (PDA@Ag) with amoxicillin (AMOX). The structure of PDA@Ag-AMOX (PAA) was characterized using TEM, UV-Vis, and FT-IR. Compared to PDA@Ag, PAA showed an increased inhibition rate of 33.3% against Escherichia coli, 31.3% against Bacillus subtilis, and 28.6% against Salmonella. It was speculated that the antimicrobial mechanism involved the reaction of Ag+ derived from PAA with functional groups of vital enzymes and proteins and the inhibitory effect of AMOX on the synthesis of bacterial cell walls and carboxypeptidase activity of binding proteins. PAA has both good coordinated antibacterial activity and high biocompatibility, which lays the foundation for the future combination and the exploration of more collaborative treatment plans among antibacterial agents. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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