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Objective To study the change of bone mineral density and hip structural strength in the females with osteoporotic hip fractures. Methods The bone mineral density and hip structure analysis was performed with DXA for 95 female patients with osteoporotic hip fractures. The age and BMI of the patients were 76. 60 ± 9. 36 years and 20. 88 ± 3. 72 kg/m². Sixty-three females ( ≥50 years old) with normal BMD were included in the control group. The age and BMI were 57.24 ± 5.65 years and 26.56 ± 4.82 kg/m² in the control group. Bone mineral density and structural strength variables including cross surface area, cortical thickness, and buckling ratio were compared between the females with osteoporotic hip fractures and the females with normal BMD. Results The females with osteoporotic hip fractures had significantly lower femoral neck BMD, cross surface area, and cortical thickness, and higher buckling ratio than the females with normal BMD. The buckling ratio at femoral neck and intertrochanter was > 10 in 87. 4% of the females with hip fractures. It was ≤ 10 in 84. 1% of the females with normal BMD. Conclusion The significant change of BMD at femoral neck and hip structural strength is present in the females with osteoporotic hip fractures, suggesting the decrease of bone strength. The HSA including structural strength variables is helpful to predict the risk of the hip fracture. [ABSTRACT FROM AUTHOR]

Objective In order to improve the diagnosis of vertebral fracture, VFA was performed during the BMD measurement. Methods VFA were consecutively performed during the BMD measurement of proximal femur in 217 postmenopausal women whose ages were over 50 years. Vertebral fracture evaluation software was used to find vertebral body fractures. According to T scores, the patients were divided into the group with BMD T > -2.5 and the group with BMD T ≤ -2.5. According to the age, the patients were divided into 50-59 yrs group, 60-69 yrs group, and ≥70 yrs group. According to the duration of menopause, the patients were divided into 0-9 yrs group, 10 - 19 yrs group, and ≥20 yrs group. The effect of BMD, age, and duration of menopause on the vertebral fracture was analyzed. In order to understand the agreement of the vertebral fracture assessment with VFA, the patients' images were performed repeatedly to assess the accordance of the evaluation by the same researcher in 2 months. The reproducibility was estimated using Kappa method. Results The vertebral fracture rate was 21. 6% in the patients with BMD T > -2. 5 and 34. 8% in the patients with BMD T ≤ -2.5. The vertebral fracture rates were 12. 5%, 25. 6%, and 44. 8% in the age groups of 50 - 59 yrs, 60-69 yrs, and ≥70 yrs, respectively. The vertebral fracture rate was significantly higher in the patients with long duration of menopause. The reproducibility indicated almost perfect agreement. Conclusion BMD measurement together with VFA for postmenopausal women at same time improves the diagnosis of vertebral fracture and osteoporosis. [ABSTRACT FROM AUTHOR]

Objective To monitor the early response to bisphosphonates treatment with bone turnover markers. Methods Serum (β-CTX P1NP were monitored for 60 postmenopausal women before and 16 weeks after the bisphosphonates treatment, in order to evaluate the efficacy of the treatment. Results β-CTX was 0.390 ±0.230 ng/ml and P1NP was 51.445 ± 25.955 ng/ml before the bisphosphonates treatment. Bone turnover was high in 24 patients and normal in 36 before the treatment. β-CTX was 0.133 ± 0.120 ng/ml and P1NP was 18.853 ± 10.225 ng/ml after the bisphosphonates treatment. The significant reduction in β-CTX and P1NP was present. The efficacy of the treatment was 95%. Conclusion The measurement of (β-CTX and P1NP are effective method for monitoring the bisphosphonates treatment. [ABSTRACT FROM AUTHOR]