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Objective To evaluate the osteogenic effects of using a 3D-printed bredigite(BRT) bone scaffold on the Onlay graft in rats. Methods BRT scaffold material was fabricated by 3D printing technology as the experimental group, β-tricalcium phosphate(β-TCP) bone scaffolds were used as the control group. The scaffolds were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), mechanical test and in vitro degradation test. An animal model of Onlay graft in SD rats was established. According to the different grafts, the animal model was divided into autogenous bone transplantation group (Auto Group), β- TCP group and BRT group. At 12 weeks after the operation, the target line was obtained for gross observation, micro CT scanning and analysis, and HE staining histological analysis. Results BRT scaffolds have distinctive surface topographywith relatively uniformly sized pores in SEM imaging. A higher mechanical strength and degradation rate was obtained with BRT scaffolds（46.80 ± 3.44) MPa, compared to β-TCP scaffolds（11.29 ± 1.30) MPa (P

Bioceramics are the ideal artificial materials of the bone scaffolds to repair the bone defects next to the traditional metal materials. The combination of additive manufacturing and bioceramics provides the enormous possibilities to achieve the customized and personalized scaffolds with more complex structures for the personalized therapy. Nowadays, the bioceramics scaffolds prepared by the additive manufacturing show the great prospects, but meet the problems of poor mechanical strength and single biofunction. To improve the mechanical properties and expand the biological functions of the bioceramics scaffolds, the influence of the slurry/powder system, debinding and sintering process, composite materials, and structure design on the mechanical properties of the bioceramics scaffolds was concluded and analyzed in this paper. The progress of the multifunctional bioceramics scaffolds was summarized from two aspects of drug release and cancer treatment. The research status of bioceramics scaffolds by additive manufacturing in vivo was also introduced. Finally, the development of bioceramics scaffolds by additive manufacturing was prospected