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OBJECTIVE: To probe into the effects of Yangzheng Touxie Qudu method combined with NAC regimen (docetaxel + epirubicin + cyclophosphamide) chemotherapy on efficacy, T cell subsets and cancer-related fatigue in patients with triple negative breast cancer. METHODS: From Jun. 2022 to Jun. 2023, totally 100 cases of triple negative breast cancer diagnosed and treated in the hospital were extracted to be divided into the control group and observation group according to the random number table method, with 50 cases in each group. The control group was treated with NAC regimen, while the observation group received self formulated Yangzheng Touxie Qudu formula combined with NAC regimen. The efficacy, T-lymphocyte subsets, inflammatory factors, cancer-related fatigue levels, and incidence of adverse drug reactions of two groups were observed. RESULTS: The total effective rate of observation group was 82. 00% (41/50), significantly higher than that 58. 00% (29/50) of control group, the difference was statistically significant (P < 0. 05). Compared with before treatment, CD3+, CD4+, CD4+ / CD8+, interleukin (IL)-12 and IL-2 levels increased significantly in both groups after treatment, and the observation group was higher than the control group; compared with before treatment, CD8+, tumor necrosis factor-α, soluble interleukin-2 receptor levels, physical, cognitive and emotional fatigue scores decreased in both groups after treatment, and the observation group was lower than the control group, with statistically significant differences (P <0.05). The incidence of adverse drug reactions in observation group and control group was respectively 24.00% (12/50) and 28.00% (14/50), with no statistically significant difference (P>0.05). CONCLUSIONS: Yangzheng Touxie Qudu method combined with NAC regimen in the treatment of patients with triple negative breast cancer can significantly improve the efficacy and T cell subsets levels, reduce inflammatory reactions, and improve cancer-related fatigue with higher safety. [ABSTRACT FROM AUTHOR]

Background The integration of Traditional Chinese Medicine (TCM) and Western Medicine in a multidisciplinary approach is the future direction for the diagnosis and treatment of Cancer-Related Fatigue (CRF). However, the lack of standard criteria for syndrome differentiation and treatment selection limits the application of TCM in Western and international contexts. Patients with CRF often experience fatigue associated with metabolic and energy balance abnormalities, with thyroid function playing a critical role in the body's energy metabolism and regulation. Objective To analyze the TCM syndrome characteristics of CRF and explore their correlation with thyroid function levels, providing a reference for the integrated diagnosis and treatment of CRF and mechanism research in both TCM and western medicine. Methods The study included cancer patients who visited the oncology outpatient and inpatient departments of the China Academy of Chinese Medical Sciences Xiyuan Hospital in 2021. General information of the patients was collected. The Chinese version of the Revised Piper Fatigue Scale (RPFS-CV) was used to assess patients' fatigue. Thyroid function tests, including triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone, anti-thyroid peroxidase antibody (TPO-Ab), and thyroglobulin antibody, were collected on the day of or the day after enrollment. TCM syndrome characteristics of CRF patients were collected through a self-designed CRF TCM Four-Diagnostic Information Form. Spearman's rank correlation analysis was used to explore the correlation between RPFS-CV fatigue scores and thyroid function indicators. Point biserial correlation analysis was used to investigate the correlation between RPFS-CV fatigue scores, thyroid function indicators, and TCM syndrome characteristics of CRF. Results A total of 159 CRF patients were included. The most common types of cancer were lung cancer (50 cases, 31.4%), breast cancer (23 cases, 14.5%), head and neck tumors (21 cases, 13.2%), rectal cancer (21 cases, 13.2%), and colon cancer (18 cases, 11.3%). The median diagnosis duration was 2.15 (3.16) years; 88 patients (55.3%) experienced recurrence or metastasis, with 40 patients (45.5%) having local recurrence and 38 patients (43.2%) having oligometastasis. The median duration of metastasis was 1.50 (2.83) years; 91 patients (57.2%) were in advanced stages, 101 patients (63.5%) had received antitumor treatment, and 57 patients (35.8%) had undergone chemotherapy. In TCM syndromes, deficiency syndromes with a frequency over 10% were Qi deficiency, heart deficiency, and spleen deficiency; among excess syndromes, those occurring more than 20 times were Qi stagnation and damp-cold. Syndromes with a median RPFS-CV fatigue score over 4 were, in descending order, damp-cold, Qi stagnation, spleen deficiency, heart deficiency, liver deficiency, damp-heat, and Qi deficiency. RPFS-CV fatigue scores were positively correlated with Qi deficiency, spleen deficiency, heart deficiency, liver deficiency, damp-cold, and Qi stagnation (P

Objective To explore the effect of feedforward control concept combined with failure mode and effect analysis (FMEA) nursing intervention on cancer-related fatigue and psychological fear in elderly pa- tients with lung cancer undergoing chemotherapy. Methods A total of 108 elderly patients with lung cancer undergoing chemotherapy admitted to the General Hospital of Jinshui District Zhengzhou City from August 2020 to April 2023 were selected and divided into control group and study group according to the order of ad- mission, with 54 cases in each group. The control group received routine nursing intervention, and the study group received nursing intervention based on feedforward control concept combined with FMEA. The modified Piper fatigue scale(RPFS) score, psychological fear, simple illness perception questionnaire (B-IPQ) score, lung function [forced expiratory volume in the first second (FEV₁), forced vital capacity (FVC), percentage of FEV, in predicted value (FEV, % perd)] and complications were compared between the two groups. Results There was no significant difference in RPFS score, psychological fear, B-IPQ score and lung function index between the two groups before intervention (P>0.05). After intervention, the scores of each dimension and total score of RPFS in the two groups were lower than those before intervention, and those in the study group were lower than the control group, differences being significant (P<0.05). After intervention, the psychological fear of the two groups was better than that before intervention, and the study group was better than the control group, the difference was statistically significant (P<0.05). After intervention, the scores of each dimension and total score of B-IPQ in the two groups were higher than those before intervention, and those in the study group were higher than the control group, the differences were statistically significant (P<0.05). After inter- vention, the levels of FEV₁, FVC and FEV, %perd in the two groups were higher than those before interven- tion, and those in the study group were higher than the control group, differences being significant (P<0.05). There were significant differences being found in the comparison of the incidence of gastrointestinal reactions and pulmonary infection between the two groups (P<0.05). Conclusion Nursing intervention based on feed- forward control concept combined with FMEA can effectively improve cancer-related fatigue and psychological fear in elderly patients with lung cancer undergoing chemotherapy, improve their ability to perceive and con- trol the disease, and better protect lung function and reduce the incidence of complications. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the dynamic changes in cancer-related fatigue (CRF) and its relationship with mitochondrial-related gene expression in cervical cancer patients undergoing concurrent chemoradiotherapy (CCRT) . Methods A prospective longitudinal study was conducted from May 2021 to October 2022 at West China Second Hospital, Sichuan University, involving 84 cervical cancer patients undergoing CCRT, with 42 patients in both the observation and control groups. CRF scores, depression scores, and six peripheral blood samples (pre-treatment and after the 1st-5th CCRT) were collected and compared with baseline data from the control group. Repeated measures, mitochondrial PCR arrays, and mixed linear models were used to analyze the trends in CRF at different treatment times, differential expression of mitochondrial-related genes, and their relationship with CRF. Results Compared to baseline, CRF worsened with increasing CCRT sessions (F=8.254, P=0.036) . Eight mitochondrial genes (EHD1, FIS1, SORL1, CXCR1, GAPDH, RAC2, ACTB, and BCL2 L1) were upregulated by more than 3-fold, while five genes (MTOR, PDK3, NSD1, MIPEP, and MSTO1) were downregulated by more than 5-fold. Nine mitochondrial genes (CXCR1, GAPDH, SORL1, MTOR, FIS1, EHD1, PDK3, NSD1, and MIPEP) showed a close association with CRF. Conclusion This study preliminarily identified nine mitochondrial genes associated with CRF, providing references for developing targeted drugs for CRF or formulating targeted nursing interventions. [ABSTRACT FROM AUTHOR]

Objective: To analyze the influencing factors of postoperative cancer-related fatigue (CRF) in patients with primary liver cancer and to construct a prediction model. Methods: 200 primary liver cancer patients who underwent surgical treatment in the First Affiliated Hospital of Hunan Normal University from January 2020 to January 2023 were selected, patients were divided into CRF group (124 cases) and non-CRF group (76 cases) according to the presence or absence of CRF at 3 months after surgical. The factors affecting postoperative CRF in primary liver cancer patients were analyzed by univariate and multivariate logistic regression analysis and to construct its prediction model. The predictive value of the prediction model for postoperative CRF in primary liver cancer patients was analyzed by receiver operating characteristic (ROC) curve. Results: Univariate analysis showed that, the course of disease in CRF group was longer than that in non-CRF group, the Child-Pugh grade B, the Eastern Cooperative Oncology Group (ECOG) score of 1～2 points, adjuvant chemotherapy, medical payment at their own expense and the proportion of depression/anxiety were higher than those in non-CRF group, and the proportion of high school education and above, family monthly income >3 000 yuan and high social support were lower than those in non-CRF group(P<0.05). Multivariate Logistic regression analysis showed that, prolonged course of disease, Child-Pugh grade B, ECOG score of 1～2 points, adjuvant chemotherapy, medical payment at their own expense, depression/anxiety were independent risk factors for postoperative CRF in primary liver cancer patients, family monthly income >3000 yuan and high social support were independent protective factors(P＜0.05). The prediction model equation of postoperative CRF in primary liver cancer patients: Logit (P)=P/1-P=-1.252+0.409×course of disease+0.839×Child-Pugh classification+1.378×ECOG score+1.055×adjuvant chemotherapy+1.476×medical payment method-0.793×family monthly income+0.883×depression/anxiety-1.260×social support. Hosmer-Lemeshaw test P>0.05. ROC curve analysis showed that, the area under the curve of the model for predicting postoperative CRF in primary liver cancer patients was 0.910, the sensitivity was 87.10%, and the specificity was 85.53%. Conclusion: The course of disease, Child-Pugh classification, ECOG score, adjuvant chemotherapy, medical payment method, depression/anxiety, family monthly income and social support are the factors affecting postoperative CRF in primary liver cancer patients, the predictive model base on this has a high predictive value for postoperative CRF in primary liver cancer patients, which may be helpful for early clinical detection and intervention of postoperative CRF in primary liver cancer patients to improve the prognosis of patients. [ABSTRACT FROM AUTHOR]

Objective: To observe the effect of buzhong yiqi decoction combined with fatigue three needles on psychological state and helper T cell (Th) 1/Th2 cytokines in patients with cancer-related fatigue (CRF) after breast cancer surgery with liver depression and spleen deficiency syndrome. Methods: Clinical data of 148 patients with CRF liver depression and spleen deficiency syndrome after breast cancer surgery who were treated in our hospital from April 2021 to April 2023 were collected, patients were divided into control group (conventional treatment and fatigue three needles treatment, n=74) and study group (buzhong yiqi decoction on the basis of control group, n=74) according to the random number table method. The pittsburgh sleep quality index (PSQI) score, efficacy, piper fatigue scale (PFS), self-rating anxiety scale (SAS), total score of TCM syndromes, self-rating depression scale (SDS), Th1/Th2 cytokines [γ-interferon (IFN-γ), interleukin-4 (IL-4), IFN-γ/IL-4] were compared between two groups. Results: The total clinical effective rate in study group was higher than that in control group (P<0.05). The total score of TCM syndromes, PFS and PSQI scores in study group were lower than those in control group after treatment(P<0.05). The SDS and SAS scores in study group were lower than those in control group after treatment(P<0.05). IL-4 in study group was lower than that in control group, and IFN-γ and IFN-γ/IL-4 were higher than those in control group after treatment(P<0.05). Conclusion: Buzhong yiqi decoction combined with fatigue three needles can improve the sleep quality and immune function of patients with CRF liver depression and spleen deficiency syndrome after breast cancer surgery, reduce the degree of fatigue and depression and anxiety, and further improve the treatment effect. [ABSTRACT FROM AUTHOR]

To investigate the effect of zhengyuan capsule combine with anlotinib on efficacy, cancer-related fatigue and immune function in patients with advanced non-small cell lung cancer (NSCLC) after second-line treatment. 103 patients with advanced NSCLC who were progressed driver gene negative after second-line treatment in Jinling Hospital Affiliated to Medical School of Nanjing University from April 2020 to May 2023 were selected, and patients were divided into control group (treated with anlotinib, n=51) and study group (treated with zhengyuan capsules combine with anlotinib, n=52) by random number table method. The clinical efficacy, Piper fatigue scale, Karnofsky functional status score (KPS), serum tumor markers [cytokeratin 19 fragment antigen 21-1 (CYFRA21-1), carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125)], immune function indicators [natural killer (NK) cells, T lymphocyte subsets: CD4+, CD8+, CD4+/CD8+] were compared between two groups, and the occurrence of adverse reactions during the treatment in two groups was observed. Compared with control group, the objective response rate (ORR) and disease control rate (DCR) in study group were higher (P<0.05). The Piper fatigue scale score in study group after treatment was lower than that in control group, KPS score was higher than that in control group. The decrease levels of serum tumor markers CYFRA21-1, CEA, and CA125 in study group were higher than those in control group (P<0.05), immune function indicators, the decrease rate of NK cells, CD4+, CD4+/CD8+ in study group was lower than those in control group, and the increase rate of CD8+ was lower than that in control group (P<0.05). There was no difference in the incidence of adverse reactions between two groups during treatment (P>0.05). Zhenyuan capsule combine with anlotinib can improve the clinical efficacy of advanced NSCLC patients with progression driver gene negative after second-line treatment, which can reducing the level of tumor markers, reducing cancer-related fatigue, improving quality of life and improving immune function. [ABSTRACT FROM AUTHOR]

Objective To analyze the relationship between stress resistance, symptom interference, and cancer-related fatigue in cancer patients undergoing radiotherapy and chemotherapy. Methods A total of 336 cancer patients undergoing radiotherapy and chemotherapy in the First Affiliated Hospital of Hebei North University from October 2020 to October 2021 were selected by convenient sampling. The related data were collected by general condition questionnaire, cancer fatigue scale (CFS), Chinese version memory symptom assessment scale (MSAS-Ch), and stress resistance scale (CD-RICS). Results The scores of cancer-related fatigues, stress resistance, and symptom disturbance were 30.55 ±8.26, 62.14 ±14.04, and 1.11 ± 0.38, respectively. The level of stress resistance played an intermediary role in symptom interference and cancer-related fatigue, accounting for 26.26% of the total effect. The level of stress resistance had a regulatory effect between symptom interference and cancer-related fatigue (3 = 0.102, AR2=0.382, P < 0.05). Conclusion The level of stress resistance plays a mediating effect and regulation between symptom interference and cancer-related fatigue. Encouraging patients to strengthen the level of stress resistance, strengthen positive psychological construction, and weaken the level of symptom interference is helpful to reduce cancer-related fatigue. [ABSTRACT FROM AUTHOR]

Adverse drug reactions have a direct impact on the treatment effect and quality of life of patients with malignant tumors. Research has found that moxibustion can effectively relieve the chemotherapy-induced adverse drug reactions. This article summarized the interventional mechanism of moxibustion and its clinical application for relieving chemotherapy-induced adverse drug reactions, in order to guide the clinical practice and improve the quality of life of cancer patients with chemotherapy. (肿瘤化疗相关不良反应严重影响患者的治疗和生活质量。艾灸可以缓解恶性肿瘤化疗相关不良反应, 减轻患者临床症状。本研究就艾灸疗法干预机制及其用于缓解肿瘤患者化疗相关不良反应的研究现状进行综述, 以期更好地指导临床实践, 提高化疗患者的生活质量。)

Objective To explore the effect of aerobic combined with resistance exercise intervention on cancer-related fatigue in patients with advanced prostate cancer undergoing chemotherapy. Methods Patients who received chemotherapy for prostate cancer in the hospital from January 2021 to December 2022 were randomly selected and divided into the control group and theobservation group, with 45 cases in each group. The study was conducted by double-blind method. The control group received routine nursing intervention, while the observation group received continuous intervention of aerobic combined with resistance exercise nursing intervention. The changes of cancer-related fatigue, sleep status and quality of life between the two groupswereobserved and compared. Results After the intervention, the observation group was significantly better than the control group in the total score of fatigue and the scores of each dimension, and the differences were statistically significant(P <0. 05). However, after the exercise intervention, the scores of the observation group in the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire and Pittsburgh Sleep Quality Index Scale all improved, and were significantly higher than those of the control group, with statistical significance(P <0. 05). Conclusion Aerobic combined with resistance exercise can alleviate the symptoms of cancer fatigue in patients with advanced prostate cancer undergoing chemotherapy, help patients face the disease with a positive attitude, improve their physical and mental health and improve their quality of life. [ABSTRACT FROM AUTHOR]

BackgroundAt least 77.0% of breast cancer patients will experience cancer-related fatigue. Hope level and resilience play as two important factors that have influence on cancer-related fatigue. Currently， most studies involve one single factor， either the level of hope or resilience， and explore its relationship with the cancer-related fatigue. Only limited studies explore the action mechanism behind with all three factors put together.ObjectiveTo investigate the mediating role of resilience between hope and cancer-related fatigue in patients with breast cancer， and to provide references for finding intervention targets for cancer-related fatigue in breast cancer patients.MethodsFrom March to October 2022， this study was conducted on the sample size of 324 hospitalized patients from three Grade-A tertiary hospitals in Shaanxi Province. These patients were over 18 years old and pathologically diagnosed as breast cancer. Hope level， resilience and cancer-related fatigue were assessed， respectively， using Adult Dispositional Hope Scale （ADHS）， Connor-Davidson Resilience Scale （CD-RISC-10） and Cancer Fatigue Scale （CFS）. Pearson Correlation Analysis was used to analyze the relationship between ADHS score， CD-RISC-10 score and CFS score. AMOS 22.0 was used to analyze the mediating effect of resilience between hope level and cancer-related fatigue in breast cancer patients.ResultsThe detection rate of cancer-related fatigue in patients with breast cancer was 88.58%. Scores of ADHS and CD-RISC-10 were negatively correlated with CFS score （r=-0.750， -0.809， P

Cancer-related fatigue is a severe form of fatigue among people with cancer, influencing the treatment outcome and quality of life of the patient. This paper reviewed the studies about cancer-related fatigue and related systematic nursing interventions, and provided evidence for establishment of systematic nursing model suited to national circumstances. (癌因性疲乏(CRF)在癌症患者中普遍存在, 严重影响患者治疗和生活质量。本研究综述CRF与系统护理干预的相关概念, 总结相关护理干预措施, 旨在为进一步探讨和建立适合我国国情的系统性护理干预模式提供参考。)

OBJECTIVE: To probe into the effects of Jieyu Chufa decoction combined with acupuncture on the scores of self-rating anxiety scale ( SAS), self-rating depression scale ( SDS), Chinese version of fatigue scale for evaluation of cancer treatment function ( FACT-F) and the expression levels of serum C-reactive protein ( CRP ), interleukin-6 (IL-6), soluble tumor necrosis factor receptor-1 (sTNF-R1) in patients with cancer-related fatigue after chemotherapy for breast cancer. METHODS: A total of 117 patients cancer-related fatigue after chemotherapy for breast cancer admitted into the hospital from Jul. 2019 to Jul 2022 were selected to be divided into 58 cases in the control group ( given conventional symptomatic treatment after chemotherapy) and 59 cases in the observation group (given Jieyu Chufa decoction combined with acupuncture after chemotherapy) via the random number table method. The course of treatment was 3 weeks. The clinical efficacy, traditional Chinese medicine (TCM) syndrome integrals (amnesia, mental fatigue, insomnia and dreaminess, anenergia), serological indicators (CRP, IL-6 and sTNF-R1), SAS, SDS and FACT-F scores of two groups were observed, and the incidences of adverse drug reactions were recorded. RESULTS: The clinical total effective rate of the observation group was 94. 92% (56 / 59), higher than that of the control group (65. 52%, 38 / 58), with statistically significant difference (P<0. 05). After treatment, the TCM syndrome integrals such as amnesia, mental fatigue, insomnia and dreaminess and anenergia in the observation group were lower than those in the control group, with statistically significant differences (P<0. 05). After treatment, the expression levels of CRP, IL-6 and sTNF-R1 were lower in the observation group were lower than those in the control group, the scores of SAS, SDS and FACT-F in the observation group were lower than those in the control group, with statistically significant differences ( P < 0. 05 ). The incidences of adverse drug reactions of control group and observation group were respectively 5. 17% (3 / 58) and 8. 47% (5 / 59), the difference was not statistically significant (P> 0. 05). CONCLUSIONS: Jieyu Chufa decoction combined with acupuncture can improve the SAS, SDS and FACT-F scores, reduce the expression levels of serum CRP, IL-6, sTNF-R1 in patients with cancer-related fatigue after chemotherapy for breast cancer [ABSTRACT FROM AUTHOR]

The “holism of physique and spirit” is a view of life in traditional Chinese medicine(TCM) that emerged from the influence of the ancient Chinese philosophy of the correlation between the physique and spirit. The physique is the carrier of human physiological and pathological activities, while the spirit is human consciousness, thoughts, emotions and other spiritual activities. Qi is the material basis of the spirit and also the bridge between the physique and spirit. Scholars often refer to the “holism of physique and spirit” as the “ holistic view of physique, qi and spirit”. This article focuses on the concept of “holism of physique and spirit” and elaborates on its role and clinical applications in the occurrence and development of cancer-related fatigue. The physique and spirit are mutually dependent, and the strength of the physique determines the strength of the spirit. The “spirit failing to function” is an important factor in the onset of cancer-related fatigue and the pathological basis for its development. The treatment of cancer-related fatigue should adhere to the principle of a “holistic view of physique, qi and spirit” and use appropriate method to regulate the five zang-organs, with tonification as the main method; and regulate the five spirits, together with comprehensive intervention; and the key to the treatment is supplementing qi, with consideration of appropriate dispersion. The combination of syndrome differentiation and treatment with non-pharmacological therapies, such as acupuncture and moxibustion, gongfu and psychological care aims to treat both the symptoms and the root cause and to harmonize the physique. Furthermore, it helps patients return to a state of “physique and spirit together” and to provide new ideas for the treatment of cancer-related fatigue in TCM. [ABSTRACT FROM AUTHOR]

This paper reviewed studies on application of Traditional Chinese Medicine five-element music therapy in in clinical nursing of patients with cancer from perspectives of cancer-related anxiety, depression, insomnia and other adverse reactions. The meaning of TCM five-element and five-tone, TCM theory and mechanism were briefly discussed to provide reference for establishment of archives of five-element music and promotion of TCM five-element therapy. (本文分析了五行音乐在肿瘤患者中的应用, 主要从五行音乐疗法对肿瘤患者相关焦虑抑郁情绪、失眠等方面的治疗进行阐述, 简单介绍了中医“五行”、“五音”的含义、中医理论、作用机制, 旨在通过数据分析建立和推广相对完善的五行音乐库, 进一步推广中医五行音疗法。)

Objective: To analyze the influencing factors of cancer-related fatigue (CRF) in patients with non Hodgkin lymphoma (NHL) chemotherapy, and to explore the intervention effect of aerobic exercise on CRF in patients with NHL chemotherapy. Methods: 142 cases of patients with NHL chemotherapy who were admitted to The First Affiliated Hospital of Air Force Military Medical University from March 2021 to April 2022 were selected, the self-made questionnaire was used to collect data from the research subjects, a total of 142 questionnaires were distributed, and 142 questionnaires were recovered, among which 138 were valid, the effective recovery rate was 97.18%. According to the occurrence of CRF, patients were divided into CRF group (n=109) and non-CRF group (n=29). Multivariate Logistic regression was used to analyze the influencing factors of patients with CRF after NHL chemotherapy. Patients with CRF after NHL chemotherapy were given aerobic exercise intervention, and the CRF, depression and anxiety degree of patients were compared before and after intervention. Results: The CRF status of 138 patients with NHL was investigated, 109 of them had occurrence of CRF, the incidence rate was 78.99%. Univariate analysis showed that the occurrence of CRF in patients with NHL chemotherapy were related to employment situation, tumor stage, chemotherapy cycle, social support degree, Hamilton Depression Scale (HAMD) score, Hamilton Anxiety Scale (HAMA) score (P<0.05). The results of multivariate Logistic regression analysis showed that tumor with stage IV, 3~4 cycles of chemotherapy cycle, high HAMD score and high HAMA score were risk factors for CRF in patients with NHL chemotherapy, and high social support degree was a protective factor (P<0.05). After intervention, the perceptual dimension, behavioral dimension, cognitive dimension, affective dimension, and total score in the CRF group were all decreased compared with those before intervention (P<0.05). After intervention, HAMA and HAMD scores in the CRF group were decreased compared with those before intervention(P<0.05). Conclusion: The occurrence of CRF in patients with NHL chemotherapy is affected by factors such as chemotherapy cycle, HAMD score, HAMA score, and and high social support degree. And adhere to aerobic exercise can reduce fatigue, relieve depression and anxiety status. [ABSTRACT FROM AUTHOR]

Background At least 77. 0% of breast cancer patients will experience cancer-related fatigue. Hope level and resilience play as two important factors that have influence on cancer-related fatigue. Currently, most studies involve one single factor, either the level of hope or resilience, and explore its relationship with the cancer-related fatigue. Only limited studies explore the action mechanism behind with all three factors put together.Objective To investigate the mediating role of resilience between hope and cancer-related fatigue in patients with breast cancer, and to provide references for finding intervention targets for cancerrelated fatigue in breast cancer patients.Methods From March to October 2022, this study was conducted on the sample size of 324hospitalized patients from three Grade-A tertiary hospitals in Shaanxi Province. These patients were over 18 years old and pathologically diagnosed as breast cancer. Hope level, resilience and cancer-related fatigue were assessed, respectively, using Adult Dispositional Hope Scale（ADHS）, Connor-Davidson Resilience Scale（CD-RISC-10） and Cancer Fatigue Scale（CFS）. Pearson Correlation Analysis was used to analyze the relationship between ADHS score, CD-RISC-10 score and CFS score. AMOS 22. 0 was used to analyze the mediating effect of resilience between hope level and cancer-related fatigue in breast cancer patients.Results The detection rate of cancer-related fatigue in patients with breast cancer was 88. 58%. Scores of ADHS and CD-RISC-10 were negatively correlated with CFS score（r=-0. 750,-0. 809, P＜0. 01）. ADHS score was positively correlated with CD-RISC-10 score（r=0. 901, P＜0. 01）. Resilience had a mediating effect between the hope level and cancer-related fatigue. The mediating effect value was-0. 676（95% CI:-1. 005～-0. 347）, accounting for 81. 90% of the total effect.Conclusion The hope level of breast cancer patients can affect cancer-related fatigue directly as well as indirectly through resilience. Resilience plays a partial mediating role between hope level and cancer-related fatigue. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Due to the subjective and persistent nature of cancer-related fatigue (CRF), the correct assessment, treatment and care of CRF symptoms in cancer patients has gradually been recognized as an important aspect of cancer follow-up treatment. This article reviews the concept of CRF and the research progress of non-drug interventions for CRF, aiming to provide reference for the clinical implementation of non-drug therapy for CRF patients. (癌因性疲乏(CRF)具有主观性、持久性, 正确评估、治疗和护理逐渐被认为是癌症后续治疗的一个重要方面。本文就CRF的概念及非药物干预研究进展进行综述, 旨在为CRF患者非药物治疗的临床实施提供参考。)

Objective To explore the effect of psychological intervention combined with nutritional support under the PERMA ［Positive Emotion (P), Engagement (E), Relationships (R), Meaning (M), Achievement (A)］ model on the psychological resilience, cancer-related fatigue, nutritional status and quality of life in patients with esophageal cancer undergoing radiotherapy and chemotherapy. Methods Totally 100 patients with esophageal cancer admitted to the hospital between January 1, 2020 and January 1, 2021 were selected as the research subjects. According to the random method, the research subjects were divided into control group (49 cases) and observation group (51 cases). The control group received routine intervention, and the observation group was given psychological intervention combined with nutritional support under PERMA model, and the two groups were intervened for 3 months. After 3 months, the scores of Connor-Davidson Psychological Resilience Scale (CD-RISC), Fatigue Scale-14 (FS-14), and Fatigue Scale-14 (FS-14). Nutrition Status Assessment Scale (MNU-ST) and Quality of Life Scale (SF-36) were observed in the two groups of patients. Results ①In the three dimensions of toughness, strength and optimism of CD-RISC scale, the psychological resilience of the two groups of patients was improved after intervention, and scores of observation group were higher than those of control group (P

Cancer-related fatigue is the most common and longest-lasting symptom of discomfort experienced by cancer patients. Its effects on patients include physical, psychological, emotional, and cognitive stress, which greatly reduce quality of life. The field of mind-body integrated medicine has improved gradually in recent years, with many evidence-based studies supporting the efficacy of mindfulness as a symptom management strategy for cancer-related fatigue. Based on a review of the literature, this paper introduces the definition of cancer-related fatigue and related assessments and treatments, describes the origin of mindfulness and related concepts, and introduces mindfulness-based empirical treatment strategies for cancer-related fatigue, including mindfulness-based stress reduction and mindfulness-based cognitive therapy, and their effects. The findings are intended to provide clinicians with a reference for the future care of patients with cancer-related fatigue. [ABSTRACT FROM AUTHOR]

Objective To review the research progress, present the research status and analyze the evolution trend of hot spots through the bibliometric analysis of the research literature of cancer-related fatigue(CRF) at home and abroad. Methods We took CRF as the theme and the papers on CRF included in CNKI and WOS core database as the research object, and used VOSviewer and CiteSpace software as research tools, to make a visual atlas analysis on the research status and hot spot evolution at home and abroad. Results (1)Research status: ① Literature: 3 646 papers (1 959 in English and 1 687 in Chinese) were finally included. The number of papers published at home and abroad showed an overall upward trend, and the proportion of foreign fund papers was high; ② domestic papers focused on nursing and rehabilitation. The research area of foreign papers was more extensive, diverse and integrated; ③ Domestic cooperation was mainly small group cooperation, while foreign cooperation was more interdisciplinary and cross-team cooperation, forming a number of core teams and research institutions; ④ Domestic scholars paid attention to clinical application research and were good at learning from foreign countries and summarizing own experience. Foreign scholars paid more attention to basic research and the treatment was more systematic and standardized; ⑤ There were a variety of diagnostic and therapeutic evaluation tools, mainly foreign scales. (2) Hot spot evolution: "quality of life" had always been a common topic of concern at home and abroad. Domestic scholars focused on clinical research and emphasized "treatment based on examination of causes" and "treatment based on syndrome differentiation". Foreign scholars attached importance to basic research and methodological research, and advocated non-drug intervention such as sports. In recent years, complementary and alternative medicine had become a hot topic in the international research. Domestic scholars had paid more attention to the research of mechanism and methodology, and expanded the application of TCM characteristic therapy in CRF. Conclusion Integrated traditional Chinese and Western medicine and multi-disciplinary participation are the future diagnosis and treatment mode of CRF. It's the direction of future efforts to establish CRF evaluation and management mode with TCM characteristic non-drug therapy as the core under integrated medicine.

ObjectiveTo discuss the effects of nursing model based on story theory on cancer-related fatigue， anxiety， depression and quality of life of gastric cancer patients.MethodsA randomized controlled trial was conducted on 120 gastric cancer patients admitted to gastroenterology department of The First Affiliated Hospital Henan University of Science and Technology from January 2017 to January 2018. Patients were randomly classified into observation group （n=61） and control group （n=59）. All patients received routine nursing， based on this， patients in observation group received nursing model based on story theory. Interventions in both groups lasted for 3 weeks. Furthermore， all individuals were assessed using Revised Piper Fatigue Scale （RPFS）， Self-rating Anxiety Scale （SAS）， Self-rating Depression Scale （SDS） and the Short-form 36 Health Survey Scale （SF-36） at the baseline and 3 weeks after intervention.ResultsAfter intervention， there was a decrease in the each dimension score of RPFS in both groups （tcontrol group=10.305~15.639， tobservation group=18.821~32.589， P

Objective: To investigate the status of cancer-related fatigue in postoperative patients with esophageal cancer, to analyze its influencing factors, and observe the relationship between cancer-related fatigue and social support and quality of life. Methods: From July 2019 to April 2021, 180 postoperative patients with esophageal cancer who were hospitalized in our hospital were selected. The clinical data of all patients were counted and sorted out. The social support of all patients was evaluated by social support rating scale (SSRS), and the quality of life of all patients was evaluated by World Health Organization quality of life scale brief (WHOQOL-BREF), the Piper Fatigue Scale (PFS) was used to evaluate cancer-related fatigue in all patients. The correlation between PFS score, SSRS score and WHOQOL-BREF score was analyzed by Pearson correlation analysis. The influencing factors of cancer-related fatigue in postoperative patients with esophageal cancer were analyzed by univariate and multivariate Logistic regression. Results: 141 cases of 180 cases of postoperative patients with esophageal cancer developed cancer-related fatigue, with an incidence of78. 33%. Patients with esophageal cancer were divided into two groups according to whether cancer-related fatigue occurred after operation: cancer-related fatigue group (n=141) and non cancer-related fatigue group (n=39). The PFS score of cancer-related fatigue group was (6. 37±1. 29) scores. Univariate analysis showed that postoperative cancer-related fatigue was related to age, sleep, nutritional status, pain degree, social support and POMS-SF score (P<0. 05). Multivariate Logistic regression analysis showed that age, sleep, nutritional status, pain degree, social support and POMS-SF score were the influencing factors of cancer-related fatigue in postoperative patients with esophageal cancer (P<0. 05). The scores and total scores of SSRS and WHOQOL-BREF in non cancer-related fatigue group were higher than those in cancer-related fatigue group (P<0. 05). Pearson correlation analysis showed that PFS score were negatively correlated with SSRS score and WHOQOL-BREF score (P<0. 05). Conclusion: The incidence of cancer-related fatigue is high in postoperative patients with esophageal cancer, which is affected by age, sleep, nutritional status, pain degree, social support, POMS-SF score, and is also associated with quality of life and social support. Clinical attention should be paid to the relevant factors, and timely early intervention should be given to prevent cancer-related fatigue or reduce the degree of cancer-related fatigue. [ABSTRACT FROM AUTHOR]

Cancer has become one of the most important public issues which seriously influence the health condition of Chinese population. The cancer-related fatigue has drawn great attention. Studies have reported that cancer-related fatigue is the most common concomitant symptom of cancer. Cancer-related fatigue could negatively affect the work, social relationship, emotions, daily activities and quality of life of cancer patients, leading to discontinuation of the treatment and even influencing the time of survival in cancer patients. However, there is no relevant guideline to instruct the clinical diagnosis and treatment of cancer-related fatigue in China. Experts and scholars from the Tumor Support and Rehabilitation Therapy Group, the Oncology Committee of Chinese Medical Association summarized the research progress of cancer-related fatigue so as to transmit important information and guide clinical practice timely. This guideline mainly covers the definition, epidemiology, clinical manifestations, pathogenesis, interfering factors, types of Traditional Chinese Medicine syndrome, screening, clinical evaluation and integrative Traditional Chinese Medicine and Western medicine treatment, aiming to provide suggestions for the clinical diagnosis and treatment of cancer-related fatigue, to facilitate the promotion of standardized treatment for patients with cancer-related fatigue, and to improve the clinical prognosis of patients with cancer-related fatigue.

Background: Acupressure is one of the recommended non-pharmacologic treatments for cancer-related fatigue (CRF) according to the National Comprehensive Cancer Network guidelines. However, few systematic review or meta-analysis studies have focused on the effect of acupressure on CRF. Purpose: The purpose of this study was to examine the effectiveness of acupressure in reducing CRF and to identify the effective acupoints and frequencies of acupressure treatments. Methods: The search and screening procedures were conducted in accordance with PRISMA 2009 guidelines. The search database included Embase, CINAHL, Cochrane Library, MEDLINE and Google Scholar. RoB 2.0 and ROBINS-I were used as appraisal tools. The statistical analysis, including effect size estimation, was computed using RevMan 5.4. Results: Twelve studies (15 sets of data) were included in the review and analysis. Nine hundred sixty patients with cancer who were currently undergoing or had completed treatment were enrolled as participants and received different levels of acupressure. The result showed the overall effect size of CRF in reducing acupressure to be SMD= -0.77, 95% CI [-0.90, -0.65]. In the subgroup analysis, the effect size of auricular acupressure was SMD= -0.98, 95% CI [-1.25, -0.71] and the body acupressure effect size was SMD= -0.70, 95% CI [-0.84, -0.56]. Conclusion/Implications for Practice: Based on the results of this systematic review, acupressure may be applied to the body acupoints Hegu (LI4), Zusanli (ST36), and Sanyinjiao (SP6) once daily for 1-3 minutes each and to the auricular acupoints shenmen and subcortex once daily for 3 minutes each to effectively reduce cancer-related fatigue. [ABSTRACT FROM AUTHOR]

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Cancer-related fatigue (CRF) is a common symptom which associated with cancer itself or cancer treatments. CRF will not only interrupt the patient's treatment, but also affect the patient's quality of life seriously. To date, the pathogenesis of CRF is still unclear, and recognized effective treatment is lacking. It is the precondition of establishing standardized animal models for CRF to find effective treatments. This paper summarizes the animal model of CRF in order to find suitable methods, and distinguish the effects of different interventions.

Objective To review the research progress, present the research status and analyze the evolution trend of hot spots through the bibliometric analysis of the research literature of cancer-related fatigue(CRF) at home and abroad. Methods We took CRF as the theme and the papers on CRF included in CNKI and WOS core database as the research object, and used VOSviewer and CiteSpace software as research tools, to make a visual atlas analysis on the research status and hot spot evolution at home and abroad. Results (1)Research status:①Literature: 3 646 papers (1 959 in English and 1 687 in Chinese) were finally included. The number of papers published at home and abroad showed an overall upward trend, and the proportion of foreign fund papers was high; ②domestic papers focused on nursing and rehabilitation. The research area of foreign papers was more extensive, diverse and integrated; ③Domestic cooperation was mainly small group cooperation, while foreign cooperation was more interdisciplinary and cross-team cooperation, forming a number of core teams and research institutions; ④ Domestic scholars paid attention to clinical application research and were good at learning from foreign countries and summarizing own experience. Foreign scholars paid more attention to basic research and the treatment was more systematic and standardized; ⑤There were a variety of diagnostic and therapeutic evaluation tools, mainly foreign scales. (2) Hot spot evolution: "quality of life" had always been a common topic of concern at home and abroad. Domestic scholars focused on clinical research and emphasized "treatment based on examination of causes" and "treatment based on syndrome differentiation". Foreign scholars attached importance to basic research and methodological research, and advocated non-drug intervention such as sports. In recent years, complementary and alternative medicine had become a hot topic in the international research. Domestic scholars had paid more attention to the research of mechanism and methodology, and expanded the application of TCM characteristic therapy in CRF. Conclusion Integrated traditional Chinese and Western medicine and multi-disciplinary participation are the future diagnosis and treatment mode of CRF. It's the direction of future efforts to establish CRF evaluation and management mode with TCM characteristic non-drug therapy as the core under integrated medicine. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Cancer has become one of the most important public issues which seriously influence the health condition of Chinese population. The cancer-related fatigue has drawn great attention. Studies have reported that cancer-related fatigue is the most common concomitant symptom of cancer. Cancer-related fatigue could negatively affect the work, social relationship, emotions, daily activities and quality of life of cancer patients, leading to discontinuation of the treatment and even influencing the time of survival in cancer patients. However, there is no relevant guideline to instruct the clinical diagnosis and treatment of cancer-related fatigue in China. Experts and scholars from the Tumor Support and Rehabilitation Therapy Group, the Oncology Committee of Chinese Medical Association summarized the research progress of cancer-related fatigue so as to transmit important information and guide clinical practice timely. This guideline mainly covers the definition, epidemiology, clinical manifestations, pathogenesis, interfering factors, types of Traditional Chinese Medicine syndrome, screening, clinical evaluation and integrative Traditional Chinese Medicine and Western medicine treatment, aiming to provide suggestions for the clinical diagnosis and treatment of cancer-related fatigue, to facilitate the promotion of standardized treatment for patients with cancer-related fatigue, and to improve the clinical prognosis of patients with cancer-related fatigue. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of lung function rehabilitation training combined with parenteral amino acid nutrition support on nutritional status, cancer-related fatigue and quality of life of patients with non-small cell lung cancer (NSCLC) after chemotherapy. Methods: 137 chemotherapy patients with NSCLC who were admitted to our hospital from June 2016 to October 2019 were selected. According to random number table method, the patients were divided into control group (68 cases, given routine intervention ), observation group (69 cases, parenteral amino acid nutrition support+lung function rehabilitation training on the basis of the control group). The nutritional status, lung function, cancer-related fatigue and quality of life of the two groups before and after intervention were compared. Results: Compared with the control group, albumin, total protein and hemoglobin in the observation group after intervention were higher (P < 0.05). The forced vital capacity (FVC), forced expiratory volume as a percentage of predicted value in the first second (FEV1%) and peak expiratory flow rate (PEF) in the observation group after intervention were higher than those in the control group (P < 0.05). after intervention, the scores of behavioral fatigue, emotional fatigue, physical fatigue and cognitive fatigue of Piper Fatigue Scale (PFS) in the observation group were lower than those in the control group (P < 0.05). The scores of each dimension of life assessment scale (EORTC QLQ-C30) of the observation group were higher than those of the control group after intervention (P < 0.05). Conclusion: Lung function rehabilitation training combined with parenteral amino acid nutrition support in the intervention of NSCLC chemotherapy patients can improve the nutritional status and lung function, relieve cancer-related fatigue and improve the quality of life. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation between malnutrition risk and cancer-related fatigue and quality of life in patients with lung cancer, and to analyze the influencing factors of malnutrition risk. Methods: 98 patients with lung cancer who were admitted to our hospital from July 2019 to July 2020 were selected as the research objects. The nutritional status, cancer-related fatigue and quality of life of all subjects were evaluated by nutritional risk screening scale 2002 (NRS-2002), cancer-related fatigue scale (CRF) and quality of life assessment scale (QLQ-C30). Pearson correlation analysis was used to analyze the correlation between NRS-2002 score, CRF score and QLQ-C30 score. Single factor and multivariate logistic regression were used to analyze the risk factors of malnutrition in lung cancer patients. Results: 24 patients without malnutrition risk (NRS-2002 score 0~2) were included in the non malnutrition risk group, and 74 patients with malnutrition risk (NRS-2002 score 3~7) were included in the malnutrition risk group. The malnutrition risk rate of the subjects was 75.51% (74/98). The scores of emotional fatigue, physical fatigue, cognitive fatigue and QLQ-C30 in malnutrition risk group were higher than those in non malnutrition risk group (P<0.05). Pearson correlation analysis showed that NRS-2002 score was positively correlated with CRF score and QLQ-C30 score (P<0.05). The results of single factor analysis showed that there were significant differences in family monthly income, age, clinical stage, nutrition management and living place between the non malnutrition risk group and the malnutrition risk group (P<0.05). Multivariate logistic regression analysis showed that the risk factors of malnutrition in lung cancer patients were clinical stage Ⅳ, family monthly income < 5000 yuan, age > 40 years old, no nutrition management, residence in rural areas (P<0.05). Conclusion: The risk of malnutrition in patients with lung cancer is high, and the risk of malnutrition is related to cancer-related fatigue and quality of life, and there are many factors influencing the risk of malnutrition. Therefore, we should formulate relevant intervention measures for these factors in clinical work. [ABSTRACT FROM AUTHOR]

Objective To explore the effect of bedtime music therapy on breast cancer patients' sleep quality and cancer-induced fatigue during radiotherapy. Methods Eighty breast cancer patients in a radiotherapy department of a tertiary hospital in Kunming were divided into an intervention group (n = 40) and a control group (n = 40) by random control grouping. Both groups of patients were given routine radiotherapy department nursing care； the patients in the intervention group received music therapy before bed during radiotherapy and within 3 months after discharge. The fatigue and sleep quality of the two groups were evaluated by Piper Fatigue revised scale and Pittsburgh sleep quality index；data collection were conducted before the intervention, at the time of discharge and 3 months after discharge. Results The Piper fatigue scale of the control group was significantly higher than the intervention group in behavior/severity, emotion, feeling, cognition/emotion scores and total scores (P < 0.05) at discharge and 3 months after discharge；Pittsburgh sleep quality scores of control group patients，except for the use of hypnotic drugs，subjective sleep quality，time to fall asleep，sleep time, sleep efficiency, sleep disorders, daytime dysfunction components scores and total PSQI scores were significantly higher than In the intervention group (P < 0.05). Conclusion Music therapy before going to bed is of positive significance in improving sleep quality and fatigue in breast cancer patients undergoing radiotherapy. [ABSTRACT FROM AUTHOR]

Objective: To investigate cancer-related fatigue in lung cancer patients undergoing chemotherapy, and analyze the relationship between cancer-related fatigue and quality of life and sleep quality. Method: 189 cases of lung cancer patients who were admitted to our hospital from March 2017 to November 2019 were selected. The clinical data of patients were collected by questionnaire. The fatigue degree of patients was evaluated by Piper Fatigue Scale (RPFS). The quality of life was evaluated by lung cancer treatment function evaluation system (FACT-L) score. Pittsburgh sleep quality index (PSQI) score was used to evaluate sleep quality. Pearson test was used to analyze the relationship between cancer-related fatigue and quality of life and sleep quality. The influencing factors of cancer-related fatigue were analyzed by univariate and multivariate Logistic regression. Result: A total of 189 questionnaires were distributed, and 182 valid questionnaires were recovered, with the recovery rate of 96.30% . In 182 cases of lung cancer patients undergoing chemotherapy, 121 cases developed cancer-related fatigue, the incidence of cancer-related fatigue was 66.48% (121/182). Patients with cancer-related fatigue were included as fatigue group (n=121), and patients without cancer-related fatigue were included as non fatigue group (n=61). The FACT-L score of fatigue group was lower than that of non fatigue group, and PSQI score was higher than that of non fatigue group (P<0.05). Pearson correlation analysis showed that RPFS score was negatively correlated with FACT-L score, but positively correlated with PSQI score (P<0.05). Univariate analysis showed that, there were significant differences in education level, family monthly income, hemoglobin, chemotherapy frequency, white blood cell count, clinical stage and albumin between the fatigue group and non fatigue group (P<0.05). Multivariate Logistic regression analysis showed that white blood cell count, family monthly income, hemoglobin, education level, chemotherapy frequency, albumin and clinical stage were the influencing factors of cancer-related fatigue in lung cancer patients undergoing chemotherapy (P<0.05). Conclusion: The generation of cancer-related fatigue in lung cancer patients undergoing chemotherapy is affected by a variety of factors, and the more severe the cancer-related fatigue is in patients, the worse their sleep quality and quality of life are. In clinical practice, intervention should be carried out for the influencing factors of cancer-related fatigue in patients as far as possible. [ABSTRACT FROM AUTHOR]

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Objective: To discuss intervention the effect of mindfulness-based stress reduction on cancer-related fatigue and negative emotions in patients of malignant tumor.Methods: A total of 122 cases of patients with malignant tumor in our hospital from July 2016 to March 2018 were selected as research subjects, all of them were divided into observation group (n=61) and control group (n=61) according to the random number table method. The control group received routine health counseling, and patients in observation group were intervened by mindfulness-based stress reduction method. The intervention course were 3 months. The cancer fatigue scale, self-rating anxiety scale, Hamilton Depression Scale (HAMD) and Functional Assessment of Cancer Therapy-Lung (FACT-L) were respectively used to evaluate the status of cancer-related fatigue, anxiety and depression status, and the life quality in two groups before and after intervention.Results: After intervention, the cognitive fatigue scores, physical fatigue scores, emotional fatigue scores and total scores of the two groups were lower than those before intervention, and the observation group were lower than the control group (P<0.05). After intervention, there was no significant difference in the self-rating anxiety scale scores and HAMD scores between the two groups (P>0. 05). After intervention, the self-rating anxiety scale scores and HAMD scores of the observation group were lower than those of the intervention group and the control group (P<0.05). The physiological status, social/family status, emotional status, functional status and additional concerns scores increased after the intervention, and the observation group were higher than that of the control group (P<0.05).Conclusion: In the intervention process of patients with malignant tumor, mindfulness-based stress reduction can significantly lighten cancer- related fatigue and improve negative emotion of malignant tumor patients. At the same time, it is also play a positive role in improving the life quality of patients. [ABSTRACT FROM AUTHOR]

Copyright of Nursing of Integrated Traditional Chinese & Western Medicine is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nursing of Integrated Traditional Chinese & Western Medicine is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nursing of Integrated Traditional Chinese & Western Medicine is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nursing of Integrated Traditional Chinese & Western Medicine is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This study aimed to explore the mechanism of Cistanches Herba in the treatment of cancer-induced fatigue(CRF) by network pharmacology combined with in vivo and in vitro experiments to provide a theoretical basis for the clinical medication. The chemical constituents and targets of Cistanches Herba were searched from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP). The targets of CRF were screened out by GeneCards and NCBI. The common targets of traditional Chinese medicine and disease were selected to construct a protein-protein interaction(PPI) network, followed by Gene Ontology(GO) functional and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analyses. A visual signal pathway rela-ted to Chinese medicine and disease targets was constructed. The CRF model was induced by paclitaxel(PTX) in mice. Mice were divided into a control group, a PTX model group, and low-and high-dose Cistanches Herba extract groups(250 and 500 mg·kg~(-1)). The anti-CRF effect in mice was evaluated by open field test, tail suspension test, and exhaustive swimming time, and the pathological morphology of skeletal muscle was evaluated by hematoxylin-eosin(HE) staining. The cancer cachexia model in C2C12 muscle cells was induced by C26 co-culture, and the cells were divided into a control group, a conditioned medium model group, and low-, medium-, and high-dose Cistanches Herba extract groups(62.5, 125, and 250 μg·mL~(-1)). The reactive oxygen species(ROS) content in each group was detected by flow cytometry, and the intracellular mitochondrial status was evaluated by transmission electron microscopy. The protein expression levels of hypoxia-inducible factor-1α(HIF-1α), BNIP3L, and Beclin-1 were detected by Western blot. Six effective constituents were screened out from Cistanches Herba. The core genes of Cistanches Herba in treating CRF were AKT1, IL-6, VEGFA, CASP3, JUN, EGFR, MYC, EGF, MAPK1, PTGS2, MMP9, IL-1B, FOS, and IL10, and the pathways related to CRF were AGE-RAGE and HIF-1α. Through GO enrichment analysis, it was found that the main biological functions involved were lipid peroxidation, nutrient deficiency, chemical stress, oxidative stress, oxygen content, and other biological processes. The results of the in vivo experiment showed that Cistanches Herba extract could significantly improve skeletal muscle atrophy in mice to relieve CRF. The in vitro experiment showed that Cistanches Herba extract could significantly reduce the content of intracellular ROS, the percentage of mitochondrial fragmentation, and the protein expression of Beclin-1 and increase the number of autophagosomes and the protein expression of HIF-1α and BNIP3L. Cistanches Herba showed a good anti-CRF effect, and its mechanism may be related to the key target proteins in the HIF-1α signaling pathway.

Objective To investigate the effects of aerobic exercise during chemotherapy on cancer-related fatigue in breast cancer patients, and related mechanism thereof. Methods Sixty breast cancer patients who underwent radical surgery were randomly assigned to exercise group and control group, 30 patients for each group. Patients in exercise group received regular nursing care plus aerobic exercise during chemotherapy, while patients in control group only received regular nursing care. The revised Piper fatigue scale (RPFS) was used to assess the fatigue degree. Values of hemoglobin concentration(Hb), maximal oxygen uptake (VO2max) and RPFS scores were detected before chemotherapy, at the end of chemotherapy and 4 weeks after chemotherapy, respectively. Results There was no significant difference in Hb concentration before chemotherapy, at the end of chemotherapy and 4 weeks after chemotherapy between two groups (P＞0.05). The level of Hb was significantly lower at the end of chemotherapy and 4 weeks after chemotherapy than that before chemotherapy in two groups (P＜0.05). There were no significant differences in VO2max and RPFS score before chemotherapy between two groups (P＞0.05). At the end of chemotherapy and 4 weeks after chemotherapy, there were no significant differences in VO2max and RPFS scores than those before chemotherapy in exercise group (P＞0.05). In control group, value of VO2max was significantly lower at the end of chemotherapy and 4 weeks after chemotherapy than that before chemotherapy (P＜0.05), RPFS score was significantly higher than that before chemotherapy (P＜0.05). Conclusion Aerobic exercise during chemotherapy can be effectively against cancer-related fatigue, which may be related to the inhibitory effect of aerobic exercise on debasement of VO2max. [ABSTRACT FROM AUTHOR]

Copyright of Nursing of Integrated Traditional Chinese & Western Medicine is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To primarily explore the efficacy of Zi Huangjing TM preparation in patients with cancer-related fatigue (CRF) during chemotherapy., Methods: This study was designed as a prospective, single-arm, multicenter clinical trial. According to the plan of the study, patients with malignant tumors who had received at least one cycle of chemotherapy and had moderate-to-severe CRF (Piper Fatigue Scale score≥4) were enrolled. All the enrolled patients took Zi Huangjing TM preparation (2.1 g, twice a day) every day during the two subsequent cycles of chemotherapy and were followed up. During the period, the enrolled patients independently completed the Piper Fatigue Scale and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) scale, and part of their biochemical and immunological indicators were measured at the baseline, before the second cycle of chemotherapy (day 21), and before the third cycle of chemotherapy (day 42). The primary endpoint was the change in Piper Fatigue Scale scores between the baseline and day 42., Results: Eventually, 47 patients completed the entire study. After treatment, the mean score of the Piper Fatigue Scale assessed before the third cycle of chemotherapy (day 42) was 3.21±1.67, which was significantly lower than that at baseline (5.89±1.36) ( P =0.000), and the patients' CRF was significantly improved. In terms of quality of life, the patient's global quality of life, physical functions, role function, emotional function, cognitive function, and social function were significantly improved. In terms of symptom management, the patient's symptoms, such as fatigue, nausea and vomiting, insomnia, and appetite loss also significantly improved. No severe adverse reactions (grades 3 and 4) occurred during the observation period of this study. After evaluation, the adverse reactions that the patients actually had were considered to be related to chemotherapy, but unrelated to Zi Huangjing TM preparation., Conclusion: According to our preliminary investigation, Zi Huangjing TM preparation is safe and has the potential therapeutic effect of improving CRF in cancer patients during chemotherapy. However, further larger-scale randomized controlled clinical studies are needed to confirm the efficacy of Zi Huangjing TM in improving CRF., (Copyright© by Editorial Board of Journal of Sichuan University (Medical Sciences).)

Cancer-related fatigue is the most common and longest-lasting symptom of discomfort experienced by cancer patients. Its effects on patients include physical, psychological, emotional, and cognitive stress, which greatly reduce quality of life. The field of mind-body integrated medicine has improved gradually in recent years, with many evidence-based studies supporting the efficacy of mindfulness as a symptom management strategy for cancer-related fatigue. Based on a review of the literature, this paper introduces the definition of cancer-related fatigue and related assessments and treatments, describes the origin of mindfulness and related concepts, and introduces mindfulness-based empirical treatment strategies for cancer-related fatigue, including mindfulness-based stress reduction and mindfulness-based cognitive therapy, and their effects. The findings are intended to provide clinicians with a reference for the future care of patients with cancer-related fatigue.

Background: Acupressure is one of the recommended non-pharmacologic treatments for cancer-related fatigue (CRF) according to the National Comprehensive Cancer Network guidelines. However, few systematic review or meta-analysis studies have focused on the effect of acupressure on CRF., Purpose: The purpose of this study was to examine the effectiveness of acupressure in reducing CRF and to identify the effective acupoints and frequencies of acupressure treatments., Methods: The search and screening procedures were conducted in accordance with PRISMA 2009 guidelines. The search database included Embase, CINAHL, Cochrane Library, MEDLINE and Google Scholar. RoB 2.0 and ROBINS-I were used as appraisal tools. The statistical analysis, including effect size estimation, was computed using RevMan 5.4., Results: Twelve studies (15 sets of data) were included in the review and analysis. Nine hundred sixty patients with cancer who were currently undergoing or had completed treatment were enrolled as participants and received different levels of acupressure. The result showed the overall effect size of CRF in reducing acupressure to be SMD= -0.77, 95% CI [-0.90, -0.65]. In the subgroup analysis, the effect size of auricular acupressure was SMD= -0.98, 95% CI [-1.25, -0.71] and the body acupressure effect size was SMD= -0.70, 95% CI [-0.84, -0.56]., Conclusions / Implications for Practice: Based on the results of this systematic review, acupressure may be applied to the body acupoints Hegu (LI4), Zusanli (ST36), and Sanyinjiao (SP6) once daily for 1-3 minutes each and to the auricular acupoints shenmen and subcortex once daily for 3 minutes each to effectively reduce cancer-related fatigue.

Cancer-related fatigue is one of the most prevalent symptoms experienced by cancer patients. The high-dose chemotherapy regimen given to those with hematological malignancies makes this group in particularly urgent need of fatigue management during hospitalization. The National Comprehensive Cancer Network (NCCN) has published practice guidelines for cancer-related fatigue. However, the complexity of these guidelines has prevented their widespread application in Taiwan. Most healthcare providers remain uncertain as to how and when to assess fatigue. This article summarizes 2011 NCCN fatigue practice guidelines, including those related to assessing fatigue patterns, intensity, and causes and choosing appropriate interventions based on patient fatigue level. The authors further share their experiences using the guideline in caring for adult hematological patients with different fatigue levels. Through these examples, we hope healthcare providers will properly apply practice guidelines and provide better care to patients experiencing fatigue. [ABSTRACT FROM AUTHOR]