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Immune thrombocytopenia（ITP）is a disease whose clinical feature is low platelet because of immunoreaction. ITP can result in high bleeding risk. However，patients with coronary artery disease （CAD）and percutaneous coronary intervention（PCI）need regular anti-platelet therapy.The treatments of ITP and CAD are contradictory.There is no standard therapy for patients with ITP and CAD.This paper reports an elderly male with ITP and acute coronary syndrome（ACS）who underwent PCI.Because of low platelet and high bleeding risk，the patient underwent several times of ACS.There was thrombogenesis in the previous stent after PCI.The patient underwent PCI and adjustment for anti-platelet therapy for several times.This case might provide some reference for clinical practice. [ABSTRACT FROM AUTHOR]