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ObjectiveTo assess the anxiety and depression symptoms and sleep quality in patients with menstrual migraine， so as to provide references for the prevention and treatment of menstrual migraine and its comorbidity.MethodsAccording to the diagnostic criteria of the International Classification of Headache Disorder， third edition （ICHD-3）， 501 female migraine patients， including 112 patients with menstrual migraine and 389 patients with non-menstrual migraine， who attended the outpatient clinic of the Affiliated Hospital of North Sichuan Medical College from February 2019 to February 2020， were selected for the study. The general and clinical data of the patients were collected， meantime， patients were assessed using Hamilton Anxiety Scale （HAMA）， Hamilton Depression Scale-24 item （HAMD-24）， 6-item Headache Impact Test （HIT-6） and Pittsburgh Sleep Quality Index （PSQI）.ResultsThe detection rates of pure anxiety， pure depression， comorbid anxiety-depression and sleep disorders in patients with menstrual migraine were higher than those in patients with non-menstrual migraine （χ2=4.198， 4.355， 5.236， 8.624， P

Objective To explore the clinical effect of the treatment of menstrual migraine (MM) by acupuncture taichong and yongquan points. Methods We selected 90 patients with confirmed diagnosis of MM from January 2017 to January 2018 and randomly divided them into three groups: acupuncture treatment group, drug therapy, and acupuncture + medication group, with 30 cases in each group. In the acupuncture treatment group, the patients were treated by using acupuncture taichong and yongquan points. Those in the drug treatment group received oral medication of fluoroguirizine hydrochloride capsules. The combined therapy group received both body acupuncture treatment and oral fluoroguirizine hydrochloride capsule treatment. We compared the total headache score, the migraine specific quality of life questionnaire (MSQ), plasma calcitonin gene-associated peptide (CGRP) and 5-hydroxytryptamine (5-HT) before and after treatment. The clinical efficacy of the three groups was compared. Results Before treatment, the headache score, MSQ, CGRP and 5-HT in the three groups did not differ (P>0.05). After treatment, the headache score, MSQ, CGRP and 5-HT of the three groups had decreased (P<0.05). Compared with the acupuncture treatment group and the drug therapy, the headache score, MSQ, CGRP and 5-HT of the three groups decreased in the acupuncture + drug therapy group (P <0.05). The total effective rate of the combination group was significantly higher than that of the other two groups (P <0.05). Conclusion The clinical effect of acupuncture taichong and yongquan points on the treatment of menstrual migraine is significant. It can significantly improve the patients' headache symptoms and lift their quality of life. [ABSTRACT FROM AUTHOR]

Objectives: To observe the curative efficacy of auricular comprehensive therapy on menstrual migraine(MM) and its effect on serum prostaglandin F2α(PGF 2α ), prostaglandin E2(PGE 2 ) contents and ratio, so as to explore its possible mechanism., Methods: A total of 66 patients with MM of liver-fire syndrome were randomly divided into observation group (33 cases, 2 cases dropped off) and control group (33 cases, 2 cases dropped off), and 20 healthy women were included in the normal group. Patients in the control group were given flunarizine hydrochloride capsules orally, twice a day, for 3 consecutive weeks. Patients in the observation group were treated with auricular comprehensive therapy, starting 2-5 days before menstrual cramps, once a week, for a total of 3 weeks. The visual analogue scale (VAS) and migraine score were evaluated before and after treatment, and follow-up for 1 and 2 menstrual cycles. Serum PGF 2α and PGE 2 contents were measured before and after treatment, and the PGF 2α /PGE 2 ratio was calculated. The clinical effective rates in the two groups were calculated., Results: After treatment and follow-up for 1 and 2 menstrual cycles, the VAS scores, headache degree, the frequency and duration of headache attacks, as well as accompanying symptoms of the observation and control groups were lower than those before treatment( P <0.05), and those of the observation group was lower than those of the control group( P <0.05). Before treatment, the PGF 2α contents in the observation and control group were significantly higher( P <0.05), while the PGE 2 contents lower( P <0.05) and PGF 2α /PGE 2 ratio higher( P <0.05) than those in the normal group. After treatment, the serum PGF 2α contents in the observation and control group were significantly reduced compared with which before treatment( P <0.05), and were lower in the observation group than that in the control group ( P <0.05). The serum PGE 2 contents in the observation and control groups were significantly increased after treatment compared with which before treatment( P <0.05), with the contents in the observation group higher than that in the control group( P <0.05). The serum PGF 2α /PGE 2 ratio in the observation and control group was significantly reduced after treatment compared with which before treatment( P <0.05), with the control group higher than the normal group( P <0.05), and the observation group lower than the control group( P <0.05). The clinical effective rate of the observation group was 93.5% (29/31), and that of the control group was 77.4% (24/31). The effective rate of the observation group was significantly higher than that of the control group( P <0.05)., Conclusions: The curative efficacy of auricular comprehensive therapy on MM with liver-fire syndrome is significantly better than that of oral flunarizine hydrochloride capsules, especially in relieving hea-daches, reducing the frequency and duration of headache attacks, as well as accompanying symptoms. Its mechanism may be related to regulating the abnormal PGF 2α and PGE 2 contents of patients and reducing the ratio of PGF 2α /PGE 2 .

Objective: To observe the clinical effect of bloodletting at auricular dorsal vein combined with auricular point sticking on menstrual migraine (MM) of qi stagnation and blood stasis, and explore its possible mechanism., Methods: A total of 102 cases of MM with qi stagnation and blood stasis were randomly divided into an observation group (51 cases, 3 cases dropped off) and a control group (51 cases, 2 cases dropped off). The patients in the observation group were treated with bloodletting at auricular dorsal vein combined with auricular point sticking. The bloodletting was performed at vein at upper 1/3 of the dorsalis near the ear helix; the auricular point sticking was performed at Pizhixia (AT 4 ), Neifenmi (CO 18 ), Jiaogan (AH 6a ), Nie (AT 2 ), Zhen (AT 3 ), Shenmen (TF 4 ) and Yidan (CO 11 ). The auricular points of both ears were alternate used. From 7 days before the onset of menstruation, bloodletting at auricular dorsal vein was given once every 7 days, 3 times were taken as a course of treatment, and 1 course of treatment was given; the auricular point sticking was given once every 3 days, and 6 times of treatment were given. The patients in the control group were treated with oral administration of flunarizine hydrochloride capsules. From 7 days before the onset of menstruation, flunarizine hydrochloride was given 2 capsules per time, once a day for 3 weeks. The menstrual headache index and visual analogue scale (VAS) score of the two groups were observed before treatment, one menstrual cycle into treatment and the first and the second menstrual cycle after treatment; the migraine-specific quality of life questionnaire (MSQ) score and the serum levels of estradiol (E 2 ) and 5-hydroxytryptamine (5-HT) were compared before treatment and one menstrual cycle into treatment; the clinical efficacy was evaluated at one menstrual cycle into treatment., Results: Compared before treatment, the menstrual headache index and VAS scores were reduced at one menstrual cycle into treatment and the first and second menstrual cycle after treatment in the two groups ( P <0.05), and those in the observation group were lower than the control group ( P <0.05). Compared before treatment, the MSQ scores and the serum levels of E 2 and 5-HT in the two groups were increased at one menstrual cycle into treatment ( P <0.05), and those in the observation group were higher than the control group ( P <0.05). The total effective rate was 95.8% (46/48) in the observation group, which was higher than 73.5% (36/49) in the control group ( P <0.05)., Conclusion: Bloodletting at auricular dorsal vein combined with auricular point sticking could relieve headache intensity, improve the quality of life in patients with MM of qi stagnation and blood stasis, which may be achieved by raising the serum levels of E 2 and 5-HT to improve the level of hormone in the body.