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With intensive and extensive using herbicides, the level of weed resistance was increased, new resistance mechanisms are constantly being discovered. Adcances on the mechanisms of target-site resistance (TSR) and non-target-site resistance (NTSR) in recent ten years were summarized in this paper. The progress of TSR mainly included new resistance mutation in herbicide target enzymes of acetolactate synthase, acetyl-CoA carboxylase and 5-enolpyruvylshikimate-3-phosphatesynthase, as well as various resistance mutations occurring in target enzyme and multiple mutated target isozymes that resisting stronger herbicide selection. In addition, the roles of NTSR in glyphosate resistance of cytochrome P450 (CYP81), aldo-keto reductase and ABC transporter protein (EcABCC8) were also described in detail. This paper is beneficial for understanding the molecular mechanisms and evolutionary laws of weed resistance from more profound and comprehensive perspective, and also provides inspriration for scientifically using herbicides and designing new herbicides with new mode of action. [ABSTRACT FROM AUTHOR]