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Drug-induced liver injury(DILI) refers to liver injury caused by one or more drugs or their metabolites after use.Due to the various types of drugs and large differences between individuals,there are many difficulties in the clinical diagnosis of DILI,and the search for new biomarkers has become a research hotspot.Related studies have shown that cytokines play a key role in DILI,especially idiosyncratic DILI.This article outlines the role of different cytokines in DILI and their value in predicting the severity and evaluating prognosis of DILI.It is pointed out that cytokines have a broad application prospect as biomarkers for DILI. [ABSTRACT FROM AUTHOR]

Hepatocellular carcinoma (HCC) is one of the most fatal malignant tumors worldwide. As an important part of cutting - edge research fields, proteomics has been widely used in the studies of related diseases and has currently become a crucial experimental approach to research on HCC. Significantly expressed proteins can be identified as potential biomarkers for early diagnosis and targets for therapeutic drugs for HCC. Moreover, they can be used for prediction of the recurrence and prognosis of HCC, as well as for investigation of pathogenesis of the disease. The proteomic results from worldwide clinical studies of HCC are summarized, and it is suggested that the clinical application of results of basic research on HCC proteomics will bring great benefit to the diagnosis and treatment of HCC. [ABSTRACT FROM AUTHOR]