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AIM: To examine how the variation of the β1-adrenergic receptor gene affects the occurrence of ventricular arrhythmias and the prognosis over a 6-month period in individuals suffering from acute ST-segment elevation myocardial infarction (STEMI). METHODS: A study was conducted retrospectively, where patients diagnosed STEMI and treated at Yunfu City People's Hospital between January 2021 and February 2023 were included based on predefined criteria. The patients were then divided into three groups according to their genotypes of the β1-adrenergic receptor Arg389Gly gene polymorphism: CC group (Arg389Arg), CG group (Arg389Gly), and GG group (Gly389Gly). Discrepancies in initial clinical data upon admission [such as Killip classification, heart rate, systolic and diastolic blood pressure, left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVDD), and serum tumor necrosis factor alpha (TNF-α), N-terminal pro-B-type natriuretic peptide (NT-proBNP), creatine kinase MB (CK-MB) and high-sensitivity C-reactive protein (hs-CRP) ], and outcomes gathered during a 6-month follow-up via telephone after discharge (heart rate, NT-proBNP, CK-MB, LVEF, LVDD, and occurrences of major adverse cardiac events) were compared across the three groups. RESULTS: The study enrolled a total of 178 STEMI patients with ventricular arrhythmias, comprising 87 cases in CC group (48. 9%), 73 cases in CG group (41. 0%), and 18 cases in GG group (10. 1%). There were no notable variances in demographic characteristics such as age, sex, weight, BMI, smoking history, alcohol consumption history, comorbidities, blood pressure, heart rate, Killip classification (III amd IV), TNF-α, NT-proBNP, CK-MB, hs-CRP, LVEF and LVDD across the three groups (P>0. 05). Following a 6-month monitoring period, the cardiac function parameters in CG and GG groups exhibited significant improvement compared to those in CC group (P<0. 05), with noteworthy lower levels of NT-proBNP and CK-MB in GG group in contrast to CG group (P<0. 05). Notably, there were significant discrepancies in the incidence of major adverse cardiac events during the follow-up period among the study groups, with 17 cases in CC group (19. 5%), 5 cases in CG group (6. 9%), and 1 case in GG group (5. 6%) (χ²=6. 887, P<0. 05). CONCLUSION: There is no correlation between the severity of STEMI accompanied by ventricular arrhythmias and the β1-adrenergic receptor Arg389Gly gene polymorphism. However, this gene variant is connected with enhancements in cardiac function and short-term prognosis post-treatment. [ABSTRACT FROM AUTHOR]

Ventricular arrhythmia is commonly seen in clinical practice. It is more common in patients with structural heart disease and can also occur in people without heart disease. Although more and more non-drug therapies have been emerging in recent years, antiarrhythmic drugs are still the basic and primary choice of treatment. Among the four major categories of antiarrhythmic drugs applied at present, (3 blockers is the only one which could reduce the total mortality rate. This paper evaluates its effectiveness on different kinds of ventricular arrhythmias. [ABSTRACT FROM AUTHOR]

Cardiologists & Partners is a physicians group initiated and established by domestic authoritative experts in the field of cardiovascular medicine. By integrating and allocating the advanced medical technologies and top-quality human resources of first class hospitals, it aims to help primary medical institutions of county level in personnel training and technical assistance. In order to make a detailed introduction to this innovative exploration in the field of cardiovascular medicine, and promote understanding of physicians group among more cardiovascular specialists, this paper focuses on the exploration and practice of physicians group from several aspects involving the epidemiology of ventricular arrhythmias, current situation of Cardiologists & Partners, its efforts in helping county hospitals, its pre-discharge management, in-hospital appliance therapy and post-discharge management, clinical research data management, future development directions, etc. [ABSTRACT FROM AUTHOR]

Objective To investigate the effects of low-level carotid baroreceptor stimulation (LL-CBS) on isoproterenol-induced ventricular arrhythmias (VAs). Methods Twenty adult mongrel dogs were randomly divided into the LL-CBS group (n=10) and the control group (n=10). The stimulating electrode of carotid artery was placed to monitor the blood pressure (BP) and heart rate (HR). After 1 hour of LL-CBS the VAs was induced by isoproterenol in the LL-CBS group. The stimulation was not stopped until the experiment was over. The false LL-CBS was given to the dogs in the control group. The ventricular effective refractory period (ERP) during baseline and 1 hour. Each dog underwent three induction episodes. The occurrence time of first arrhythmic beat, the number of ventricular premature beat, the number and the duration of ventricular tachycardia were measured and analyzed. Results The values of BP and HR were not significantly different between the two groups during baseline, 1 hour and intravenous isoproterenol (all P>0 .05 ). The ERP was (165 ±5) ms in the LL-CBS group and (168 ±8) ms in the control group during baseline (P>0.05), and the ERP was respectively (181 ±7) ms and (162 ±7) ms in the LL-CBS group and control group 1 hour after stimulation (P<0.05). The occurrence of VAs in the LL-CBS group was less than that in the control group every time (all P<0.05). The occurrence time of first ventricular premature beat of the LL-CBS group was 341 (512, 224) s, and 215 (327, 90) s in the control group;the number of premature ventricular contractions was 52 (83, 20), and 107 (162, 54) in the control group; and the number of ventricular tachycardia was 2.3 (6.7, 0.5), and 5.5 (9.3, 2.4) in the control group (all P<0.05). Conclusion LL-CBS inhibits the occurrence of isoproterenol-induced VAs without chan-ges of BP and HR. [ABSTRACT FROM AUTHOR]

Objective: To explore the predictive value of T wave peak to end(Tp-Te) interval and Tp-Te interval dispersion(Tp-Ted) in acute myocardial infarction combined with ventricular arrhythmias. Methods: 140 patients who were diagnosed as ST-segment elevation myocardial infarction(STEMI) hospitalized in our hospital from May 2013 to May 2014 were enrolled and divided into ventricular tachycardia(VT) group, ventricular premature beat(VPB) group and group without ventricular arrhythmias according the types of ventricular arrhythmias. The Tp-Te interval and Tp-Ted of the electrocardiogram of the three groups were analyzed and compared. Results: FPG, Tp-Te and Tp-Ted of patients in acute phase were higher than those of patients in recovery phase, and the differences were statistically significant(P<0.05). There was no statistically significant difference about the levels of TG, CHOL, LDL-C,K+and Na+between the acute phase and the recovery phase(P>0.05). Compared with VT and VPB group, Tp-Te and Tp-Ted of the non-ventricular arrhythmias group were lower, and the differences were statistically significant(P<0.05). Tp-Te and Tp-Ted of VPB group were lower than those in VT group with statistically significant differences(P<0.05). Conclusion: Tp-Te interval and Tp-Ted can be used to differentiate different types of ventricular arrhythmias in patients with acute myocardial infarction. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the clinical efficacy of amiodarone combined with metoprolol in treatment of chronic heart failure (CHF) with ventricular arrhythmias (VA). METHODS: 81 patients with CHF and VA admitted from Mar. 2012 to Mar. 2015 were selected to be divided into observation group and control group via the random number table. 40 cases in the observation group were treated with amiodarone combined with metoprolol, while 41 cases in the control group received amiodarone. The cardiac function changes of VA, readmission and cardiac event of two groups were observed; and the adverse drug reactions were compared between two groups. RESULTS: After treatment of 6 months, as for VA, the total effective rate of observation group was 92.50% (37/40), significantly higher than that of control group [75.61% (31/41)], with statistically significant difference (P <0.05). As forcardiac functionm, the total effective rate of observation group was 85.00% (34/40), significantly higher than that of control group [65.85% (27/41)], with statistically significant difference (P <0.05). The incidence of readmissionand cardiac event in observation group were significantly lower than that of control group , with statistically significant difference (P <0.05). There were no significant difference between two groups in incidence of adverse drug reactions (P >0.05). CONCLUSIONS: The efficacy of amiodarone combined with metoprolol in treatment of CHF with VA isremarkable, with high safety. It is worthy of clinical application and promotion. [ABSTRACT FROM AUTHOR]

Objective: To analyze the clinical characteristics of patients with idiopathic right ventricular outflow tract (RVOT) ventricular arrhythmias (VA) and factors related to the immediate success rate of radiofrequency ablation. Methods: Patients diagnosed as idiopathic RVOT arrhythmia in Fuwai Hospital from February 2009 to January 2013 were retrospectively screened. Patients with structural heart disease or inherited arrhythmia were excluded. All patients underwent endocardial electrophysiological study and radiofrequency catheter ablation. Baseline clinical and operation records were collected and analyzed. Immediate success rate was defined as no inducible ventricular arrhythmia by isoprinosine and electrophysiological induction at the end of ablation. The origins of idiopathic RVOT were classified as septal, anterior, posterior, free wall site, epicardial and RVOT-aorta root site. Results: A total of 468 patients were finally included, and the age was (40.4±13.3) years old and 60.5%(283/468) patients were female. Immediate radiofrequency success rate was 89.3%(418/468). Patients were divided into ablation success group ( n= 418) and ablation failure group ( n= 50). Percent of female patients and patients with interventricular septal origin was significantly higher in the ablation success group than in ablation failure group (261(62.4%) vs. 22 (44.0%) , P= 0.01, and 233(55.7%) vs. 18(36.0%), P= 0.005), while percent of patients with epicardial origin was significantly lower in the ablation success group than in ablation failure group (17(4.1%) vs. 11(22.0%), P< 0.001). Immediate success rate was the highest for patients with the septal origin and the lowest for patients with epicardial origin (92.8%(233/251) vs. 60.7%(17/28), P< 0.05). Multivariate analysis showed that the origin site of VAs was the most important independent factor related to the success rate of ablation. Compared with the septal origin patients, patients with RVOT-aorta root and epicardial origin VAs faced with 1.82-fold and 8.26-fold increased risk of failed ablation, respectively ( OR= 2.82, 95% CI 1.05-7.57, and OR= 9.26, 95% CI 3.60-23.86). Sex category was not the independent risk factor for failed ablation( OR =1.76, 95% CI 0.93-3.33, P =0.08) . Conclusions: The immediate success rate of radiofrequency catheter ablation for idiopathic RVOT ventricular arrhythmia is relative high, however, immediate success rate of radiofrequency catheter ablation is relatively low for patients with epicardial and RVOT-aorta root origin arrhythmia and VAs origin is an independent risk factor of immediate ablation success rate.