1. Real-Time In Situ Powder X-ray Diffraction Monitoring of Mechanochemical Synthesis of Pharmaceutical Cocrystals
- Author
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Bhavnita Patel, William Jones, Frank Adams, Veijo Honkimäki, Robert E. Dinnebier, Patrick J. Beldon, Simon A. J. Kimber, Vjekoslav Štrukil, Tomislav Friščić, Ivan Halasz, Ana M. Belenguer, and Andreas Puškarić
- Subjects
In situ ,Reaction mechanism ,Materials science ,010405 organic chemistry ,Nanotechnology ,General Medicine ,General Chemistry ,cocrystals ,mechanochemistry ,pharmaceutical materials ,reaction monitoring ,X-ray diffraction ,010402 general chemistry ,01 natural sciences ,Cocrystal ,Catalysis ,0104 chemical sciences ,Grinding ,Chemistry ,Mechanochemistry ,X-ray crystallography ,Particle ,sense organs - Abstract
Looking in: The penetrating power of high-energy X-rays provides a means to monitor in situ and in real time the course of ball-milling reactions of organic pharmaceutical solids by detecting crystalline phases and assessing the evolution of their particle sizes. Upon switching from neat grinding to liquid-assisted grinding, cocrystal formation is enabled or tremendously accelerated, while the reaction mechanism alters its course.
- Published
- 2013