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The article deals with the secretion of Sertoli cells. Different substances they secrete and their role in the testis are described. These cells release a number of factors in their environment, thus creating a local "milieu" and exerting a local control of spermatogenesis in the seminiferous tubules. As target cells for FSH and testosterone, Sertoli cells are also included in a systemic control of spermatogenesis, and because of that, they are necessary for the normal function of the male sex gland.

During the last decade and especially during the last several years the question of the inhibin presence in the gonads of both sexes has been in the focus of researcher's interests. According to what has been known up to date the inhibins are produced by Sertoli cells in the testis and by granulosa cells in the ovary. The inhibin activity is many-sided. It inhibits the synthesis and the discharge of the FSH what also leads to the reduction of LH-RH content. Additionally it also inhibits the process of spermatogonium multiplication in the testis and of the progesterone multiplication in the ovary. In this paper a synthesis of the known facts from the histophysiologic aspect has been given, without taking into consideration the possible future clinical and therapeutic effects of these facts still being researched.