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The tested anaesthesia through a permanent infusion of a xylazine, ketamine and guaifenezine (XKG) mixture was used in ten experimental dogs without clinical signs of a disease and in fifty two patients during different surgical interventions. After joint i.m. atropine (0.05 mg/kg) and xylazine (2 mg/kg) premedication, anaesthesia in dogs was induced by an i.v. administration of 1% ketamine at a dose of 2 mg/kg, and the XKG was infused instantly after the previous treatment. The mixture contained 2.0 ml of 5% ketamine and 1.25 ml of 2% xylazine added to 100 ml of 5% guaifenezine. The infusion was applied at a rate of 3.3 ml/kg for the first five minutes and then it was maintained at constant values of 2.2 ml/kg during the whole surgical intervention (Tab. I). The induction and course of anaesthesia, and waking up and recovery from anaesthesia were evaluated in all dogs, and the trias values were also followed. These additional parameters were followed in the test group: breathing volumes, ECG values and acid-base balance parameters were determined from the collected blood samples. The observation of measurable parameters (Figs. 1 to 5) and ECG analysis did not demonstrate any large departures from the starting values, and the changes in the acid-base balance (Tab. II) suggest the partly compensated respiratory acidosis. On the basis of our results, we can recommend this tested method for general anaesthesia particularly of dogs of larger breeds and for longer-lasting operations. This method is suitable to be used first of all in the veterinary establishments where inhalation anaesthesia is not practicable.

Tests of the effect of the new steroid anaesthetic alfadion in the drug Althesin are described. Experiments were carried out in three experimental groups. Intramuscular administration of Althesin to dogs at doses 5 to 15 mg. kg-1 does not induce required anaesthesia. After intravenous administration of Althesin to dogs at a dose of 2 mg. kg-1 after diazepam pre-medication at a dose of 0.25 mg.kg-1 i. m., anaesthesia started without excitations immediately after completed application. Anaesthesia lasted on the average 10 minutes and at the time of recovery excitations and side effects occurred. After intravenous administration of Althesin at a dose of 6 mg. kg-1 with diazepam pre-medication 0.25 mg. kg-1 i.m., the course of narcosis in cats was similar to that in dogs, only its duration was on the average 29 minutes.