1. [Triple combination treatment of chronic hepatitis C].
- Author
-
Husa P
- Subjects
- Drug Therapy, Combination, Humans, Interferon-alpha administration & dosage, Oligopeptides administration & dosage, Polyethylene Glycols administration & dosage, Proline administration & dosage, Proline analogs & derivatives, Protease Inhibitors administration & dosage, Recombinant Proteins administration & dosage, Ribavirin administration & dosage, Antiviral Agents administration & dosage, Hepatitis C, Chronic drug therapy
- Abstract
The 2011 has brought about a significant change in the treatment of chronic hepatitis C virus (HCV) infection. This change has been enabled by commercial availability of new antiviral agents for treatment of chronic HCV infection - telaprevir and boceprevir - in combination with pegylated interferon (PEG-IFN) α and ribavirin (RBV). The triple combination is significantly more effective than the PEG-IFN and RBV combination alone in antiviral treatment-naive patients as well as in patients in whom the traditional PEG-IFN and RBV combination did not provide permanent HCV infection elimination. In treatment-naive patients, the triple combination is approximately 2-fold more effective than the standard treatment with PEG-IFN and RBV and the effect of the triple combination is 3-fold higher when used in pre-treated patients instead of repeated PEG-IFN and RBV treatment.
- Published
- 2012