1. [Dabigatran as cause of severe gastrointestinal bleeding in a Jehovah's Witness patient].
- Author
-
Holm J and Taskiran M
- Subjects
- Aged, Antithrombins pharmacology, Antithrombins therapeutic use, Atrial Fibrillation drug therapy, Benzimidazoles pharmacology, Benzimidazoles therapeutic use, Blood Transfusion psychology, Critical Illness therapy, Dabigatran, Female, Gastrointestinal Hemorrhage therapy, Humans, Jehovah's Witnesses, Plasma, Treatment Outcome, Treatment Refusal, beta-Alanine adverse effects, beta-Alanine pharmacology, beta-Alanine therapeutic use, Antithrombins adverse effects, Benzimidazoles adverse effects, Gastrointestinal Hemorrhage chemically induced, beta-Alanine analogs & derivatives
- Abstract
We report a case of severe gastrointestinal bleeding in a Jehovah's Witness patient after ten days of treatment with dabigatran. The patient refused to have a blood transfusion due to belief. An endoscopic examination showed diffuse bleeding from her colonic mucosa, which is typical for medical induced bleedings. The patient was in a life-threatening condition and the haemoglobin level fell to nadir 2 mmol/l, before the bleeding stopped after one week's pause of dabigatran therapy. Since an antidote to dabigatran does not exist, precaution is needed when treating patients, who might refuse to have blood transfusion.
- Published
- 2013