1. [Cardiotoxicity induced by 5-fluorouracil or capecitabine].
- Author
-
Jensen SA, Baeksgaard L, Petersen LN, Reiter L, and Sørensen JB
- Subjects
- Antimetabolites, Antineoplastic administration & dosage, Antimetabolites, Antineoplastic metabolism, Capecitabine, Colorectal Neoplasms drug therapy, Deoxycytidine administration & dosage, Deoxycytidine adverse effects, Deoxycytidine metabolism, Fluorouracil administration & dosage, Fluorouracil metabolism, Heart Diseases prevention & control, Humans, Isosorbide Dinitrate administration & dosage, Isosorbide Dinitrate analogs & derivatives, Nitroglycerin administration & dosage, Prodrugs, Risk Factors, Vasodilator Agents administration & dosage, Antimetabolites, Antineoplastic adverse effects, Deoxycytidine analogs & derivatives, Fluorouracil adverse effects, Fluorouracil analogs & derivatives, Heart drug effects, Heart Diseases chemically induced
- Abstract
5-fluorouracil and capecitabine have significant antineoplastic activity towards various solid tumors. Cardiotoxicity causing angina, arrhythmia and infarction are serious adverse events associated with these agents. The pathogenesis is discussed and symptoms of cardiotoxicity, intervention with nitroglycerine and risk factors as cardiac comorbidity are described. Following cardiotoxicity, lack of alternative active agents may provide grounds to rechallenge with 5-FU. In this situation, dose-modified 5-FU-based chemotherapy supported by medical antiangina prevention is feasible.
- Published
- 2010