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1. [Phenotype- or genotype test for dihydropyrimidin dehydrogenase deficiency before treatment with a fluoropyrimidine].

Author

Andersen SE, Paulsen NH, Pfeiffer P, Qvortrup C, and Damkier P

Subjects
Antimetabolites, Antineoplastic therapeutic use, Dihydrouracil Dehydrogenase (NADP) genetics, Fluorouracil adverse effects, Genotype, Humans, Phenotype, Dihydropyrimidine Dehydrogenase Deficiency drug therapy, Dihydropyrimidine Dehydrogenase Deficiency genetics
Abstract

Some patients may have partial or complete deficiency of dihydropyrimidin dehydrogenase (DPD) and be more likely to experience severe toxicity with 5-fluorouracil. Since the spring of 2020, the Danish Medicines Agency has recommended genotype or phenotype testing before treatment with a fluoropyrimidine, but the most appropriate test strategy is debated. In this review, we present polymorphisms in the genes coding for DPD and summarise the evidence for DPD-enzyme deficiency testing and pharmacokinetic guided dosing.

Published
2021

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