1. [Simultaneous measurement of end-diastolic pressure in the left ventricle and transmitral flow before and after nitroglycerin in patients with angina pectoris].
- Author
-
Gøtzsche CO and Rasmussen K
- Subjects
- Adult, Aged, Angina Pectoris drug therapy, Angina Pectoris physiopathology, Coronary Circulation drug effects, Echocardiography, Doppler drug effects, Female, Humans, Male, Middle Aged, Mitral Valve physiology, Stroke Volume drug effects, Stroke Volume physiology, Ventricular Function, Left drug effects, Angina Pectoris diagnosis, Blood Pressure physiology, Coronary Circulation physiology, Nitroglycerin administration & dosage, Ventricular Function, Left physiology
- Abstract
In angina pectoris, left ventricular diastolic function evaluated by end-diastolic pressure (LVEDP) on catheterization and transmitral flow (TMF) on Doppler echocardiography is abnormal. As a parameter describing TMF, the ratio between peak flow velocities of the two filling phases in diastole (PE/PA) can be used. We examined 22 patients with angina pectoris and measured LVEDP and PE/PA simultaneously and found positive correlation (r = 0.60). Nitroglycerin (0.8 mg sublingually) reduced LVEDP and PE/PA significantly, and correlation between reductions was positive (r = 0.52). None of the correlation analyses permitted LVEDP to be calculated from PE/PA, but Doppler echocardiography and TMF will probably be used increasingly in evaluation of ischemic heart disease with medical intervention.
- Published
- 1991