1. [Etomidate can not be recommended to patients with septic shock].
- Author
-
Toft P and Jensen AG
- Subjects
- Adrenal Glands drug effects, Adrenal Glands physiopathology, Anesthetics, Intravenous administration & dosage, Etomidate administration & dosage, Humans, Hypnotics and Sedatives administration & dosage, Intubation, Intratracheal, Anesthetics, Intravenous adverse effects, Etomidate adverse effects, Hypnotics and Sedatives adverse effects, Shock, Septic mortality, Shock, Septic physiopathology, Shock, Septic therapy
- Abstract
Due to a low cardiovascular complication rate even in patients with shock, etomidate is often used for intubation. Etomidate inhibits the steroid synthesis. A single bolus injection of etomidate has so far been considered to be safe. However, new investigations have shown that even a single bolus dose of etomidate inhibits the steroid synthesis and is associated with increased mortality in patients with septic shock.
- Published
- 2011