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1. [Deficiency of mannan-binding protein--a recently discovered complement defect syndrome].

Author

Garred P, Thiel S, Madsen HO, Ryder LP, Jensenius JC, and Svejgaard A

Subjects
Carrier Proteins immunology, Collectins, Humans, Immunologic Deficiency Syndromes immunology, Infant, Receptors, Complement immunology, Receptors, Complement metabolism, Syndrome, Carrier Proteins chemistry, Complement Pathway, Classical immunology, Immunologic Deficiency Syndromes etiology
Abstract

Mannan-binding protein (MBP) is a newly discovered serum protein which activates the complement system by the classical pathway by binding to mannose-rich surfaces on microorganisms. MBP deficiency predisposes to infection in infancy. MBP is a C-type lectin with collagen structure, a so-called collection. The paper discusses the structure and physiological functions of MBP. MBP may be an important parameter in the investigation of immunodeficiencies in children.

Published
1993

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