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1. [Meta-analysis of pharmacological therapy with acamprosate, naltrexone, and disulfiram--a systematic review].

Author

Petrov I, Krogh J, and Nordentoft M

Subjects
Acamprosate, Evidence-Based Medicine, Humans, Taurine therapeutic use, Treatment Outcome, Alcohol Deterrents therapeutic use, Alcoholism drug therapy, Disulfiram therapeutic use, Naltrexone therapeutic use, Taurine analogs & derivatives
Abstract

The meta-analysis is based on 16 randomized controlled trials of acamprosate, 18 of naltrexone and 7 of disulfiram. Acamprosate and naltrexone were 52% (RR = 1.52; 95% confidence interval (CI): 1.35-1,72) and 27% (RR = 1.27; 95% CI: 1,06-1,52) better than placebo when it came to supporting continuous abstinence. Acamprosate increased the total number of abstinence days with 14% (MD = 14.02; 95% CI: 9.57-18.47). Disulfiram appeared to be effective only when the intake was supervised. Based on the amount of scientific evidence, acamprosate and naltrexone therapy should be increased in clinical practice in the treatment of alcoholism.

Published
2011

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