1. Enhancement of the radiation response with interleukins and interferons
- Author
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Carsten Herskind, F. Wenz, Chuan-Yuan Li, F. Lohr, Jens G. Lohr, Nieder, C., Milas, L., and Ang, K.K.
- Subjects
medicine.medical_specialty ,Particle therapy ,business.industry ,medicine.medical_treatment ,Planning target volume ,Normal tissue ,Dose distribution ,Holy Grail ,Radiation therapy ,medicine ,Radiology ,business ,Intensity modulation ,Radiation response - Abstract
Physical and technical developments and refinements of the last decade in radiation oncology have been impressive. Particle therapy is on the rise again, and photon therapy has received a major boost from intensity modulation, making delivery of tumor-conformal radiation treatment easier than ever before. Intensity-modulated particle therapy, regarded by some as the holy grail of radiotherapy, is on the horizon, combining highly conformal dose distributions with low integral doses. However, while any desired dose distribution can be created now or in a not too distant future, this does not solve the problem of normal tissue present within the irradiated target volumes due to infiltration by the tumor. Therefore, further progress can only be expected from efforts directed at widening the therapeutic window between tumors and normal tissue through specific modulation of their responses to radiotherapy.
- Published
- 2003