1. The balance among immune suppression, stem cell ablation, competition, and engraftment
- Author
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Gerald de Haan, Ronald van Os, Rijksuniversiteit Groningen, Damage and Repair in Cancer Development and Cancer Treatment - 1, and Stem Cell Aging Leukemia and Lymphoma
- Subjects
Immunosuppression Therapy ,medicine.medical_treatment ,Immunology ,Congenic ,Cell Biology ,Hematology ,Biology ,Hematopoietic Stem Cells ,Ablation ,Biochemistry ,Therapeutic immunosuppression ,Endothelial stem cell ,Mice ,Donor bone marrow ,Immune system ,Models, Animal ,Catheter Ablation ,Cancer research ,medicine ,Animals ,Leukocyte Common Antigens ,Local irradiation ,Stem cell ,Stem Cell Transplantation - Abstract
Ito and coworkers[1][1] describe a model where local irradiation enhances engraftment of CD45 congenic donor bone marrow cells. Their explanation is that the irradiated marrow sites produce cytokines that help proliferation of locally homed stem cells and initiate migration of stem cells to other
- Published
- 2004