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Start Over Author "Marcus, L." Language dutch; flemish
4 results on '"Marcus, L."'

1. [Clinical course of COVID-19 in the Netherlands: an overview of 2607 patients in hospital during the first wave]

Author

Marcel J H, Ariës, Joop P, van den Bergh, Martijn, Beudel, Wim, Boersma, Tom, Dormans, Renee A, Douma, Annet, Eerens, Paul W G, Elbers, Lucas M, Fleuren, Niels C, Gritters van den Oever, Lianne, de Haan, Iwan J C C, van der Horst, Shi, Hu, Deborah, Hubers, Marcus L F, Janssen, Martijn, de Kruif, Pieter L, Kubben, Sander M J, van Kuijk, Peter G, Noordzij, Maarten, Ottenhoff, Dan A I, Piña-Fuentes, Wouter V, Potters, Auke C, Reidinga, Roos S C, Renckens, Sander, Rigter, Daisy, Rusch, Michiel, Schinkel, Kim C E, Sigaloff, Suat, Simsek, Patricia, Stassen, Robert, Stassen, Rajat M, Thomas, Guido A, van Wingen, Anton, Vonk Noordegraaf, Max, Welling, W Joost, Wiersinga, Marije D J, Wolvers, and Caroline E, Wyers

Subjects
Male, Critical Care, Diagnostic Tests, Routine, SARS-CoV-2, Age Factors, COVID-19, Comorbidity, Kaplan-Meier Estimate, Severity of Illness Index, Cardiovascular Diseases, Risk Factors, Humans, Female, Hospital Mortality, Aged, Netherlands
Abstract

To systematically collect clinical data from patients with a proven COVID-19 infection in the Netherlands.Data from 2579 patients with COVID-19 admitted to 10 Dutch centers in the period February to July 2020 are described. The clinical data are based on the WHO COVID case record form (CRF) and supplemented with patient characteristics of which recently an association disease severity has been reported.Survival analyses were performed as primary statistical analysis. These Kaplan-Meier curves for time to (early) death (3 weeks) have been determined for pre-morbid patient characteristics and clinical, radiological and laboratory data at hospital admission.Total in-hospital mortality after 3 weeks was 22.2% (95% CI: 20.7% - 23.9%), hospital mortality within 21 days was significantly higher for elderly patients (70 years; 35, 0% (95% CI: 32.4% - 37.8%) and patients who died during the 21 days and were admitted to the intensive care (36.5% (95% CI: 32.1% - 41.3%)). Apart from that, in this Dutch population we also see a risk of early death in patients with co-morbidities (such as chronic neurological, nephrological and cardiac disorders and hypertension), and in patients with more home medication and / or with increased urea and creatinine levels.Early death due to a COVID-19 infection in the Netherlands appears to be associated with demographic variables (e.g. age), comorbidity (e.g. cardiovascular disease) but also disease char-acteristics at admission.

Published
2021

2. Klinisch beloop van covid-19 in Nederland: Een overzicht van 2607 ziekenhuispatiënten uit de eerste golf

Author

Ariës, Marcel J H, van den Bergh, Joop P, Beudel, Martijn, Boersma, Wim, Dormans, Tom, Douma, Renee A, Eerens, Annet, Elbers, Paul W G, Fleuren, Lucas M, Gritters van den Oever, Niels C, de Haan, Lianne, van der Horst, Iwan J C C, Hu, Shi, Hubers, Deborah, Janssen, Marcus L F, de Kruif, Martijn, Kubben, Pieter L, van Kuijk, Sander M J, Noordzij, Peter G, Ottenhoff, Maarten, Piña-Fuentes, Dan A I, Potters, Wouter V, Reidinga, Auke C, Renckens, Roos S C, Rigter, Sander, Rusch, Daisy, Schinkel, Michiel, Sigaloff, Kim C E, Simsek, Suat, Stassen, Patricia, Stassen, Robert, Thomas, Rajat M, van Wingen, Guido A, Vonk Noordegraaf, Anton, Welling, Max, Wiersinga, W Joost, Wolvers, Marije D J, Wyers, Caroline E, Intensive Care, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: MA Medische Staf IC (9), MUMC+: MA Intensive Care (3), RS: Carim - V04 Surgical intervention, Klinische Neurowetenschappen, MUMC+: HZC Med Staf Spec Klinische Neurofys (9), RS: MHeNs - R3 - Neuroscience, Neurochirurgie, MUMC+: MA Med Staf Spec Neurochirurgie (9), MUMC+: KIO Kemta (9), Epidemiologie, RS: CAPHRI - R2 - Creating Value-Based Health Care, RS: CAPHRI - R5 - Optimising Patient Care, MUMC+: MA Alg Interne Geneeskunde (9), Interne Geneeskunde, and Family Medicine

Subjects
Male, Cardiovascular Diseases/epidemiology, SARS-CoV-2/isolation & purification, Age Factors, Critical Care/methods, Netherlands/epidemiology, Comorbidity, Kaplan-Meier Estimate, Severity of Illness Index, Risk Factors, Humans, Diagnostic Tests, Routine/methods, Female, Hospital Mortality, Aged, COVID-19/epidemiology
Abstract

OBJECTIVE: To systematically collect clinical data from patients with a proven COVID-19 infection in the Netherlands. DESIGN: Data from 2579 patients with COVID-19 admitted to 10 Dutch centers in the period February to July 2020 are described. The clinical data are based on the WHO COVID case record form (CRF) and supplemented with patient characteristics of which recently an association disease severity has been reported. METHODS: Survival analyses were performed as primary statistical analysis. These Kaplan-Meier curves for time to (early) death (3 weeks) have been determined for pre-morbid patient characteristics and clinical, radiological and laboratory data at hospital admission. RESULTS: Total in-hospital mortality after 3 weeks was 22.2% (95% CI: 20.7% - 23.9%), hospital mortality within 21 days was significantly higher for elderly patients (> 70 years; 35, 0% (95% CI: 32.4% - 37.8%) and patients who died during the 21 days and were admitted to the intensive care (36.5% (95% CI: 32.1% - 41.3%)). Apart from that, in this Dutch population we also see a risk of early death in patients with co-morbidities (such as chronic neurological, nephrological and cardiac disorders and hypertension), and in patients with more home medication and / or with increased urea and creatinine levels. CONCLUSION: Early death due to a COVID-19 infection in the Netherlands appears to be associated with demographic variables (e.g. age), comorbidity (e.g. cardiovascular disease) but also disease char-acteristics at admission.

Published
2021

3. [Current diagnostics and treatment options for tinnitus].

Author

Smit JV, Janssen MLF, and de Kleine E

Abstract

Tinnitus is a common condition with great variability in the intensity of symptomatology. In recent years, more and more insights have been gained into the mechanism of tinnitus and its relationship with hearing loss and other factors such as stress. Depending on the symptoms and clinical findings, a patient may be referred to an ENT specialist or audiologist. For the majority of patients, re-assurance and providing good information is sufficient. For others improving hearing and possibly cognitive behavioral therapy remains the most important pillars for treatment of tinnitus. A number of experimental treatments are currently underway which offer hope for the future.

Published
2023

4. [Clinical course of COVID-19 in the Netherlands: an overview of 2607 patients in hospital during the first wave].

Author

Ariës MJH, van den Bergh JP, Beudel M, Boersma W, Dormans T, Douma RA, Eerens A, Elbers PWG, Fleuren LM, Gritters van den Oever NC, de Haan L, van der Horst IJCC, Hu S, Hubers D, Janssen MLF, de Kruif M, Kubben PL, van Kuijk SMJ, Noordzij PG, Ottenhoff M, Piña-Fuentes DAI, Potters WV, Reidinga AC, Renckens RSC, Rigter S, Rusch D, Schinkel M, Sigaloff KCE, Simsek S, Stassen P, Stassen R, Thomas RM, van Wingen GA, Vonk Noordegraaf A, Welling M, Wiersinga WJ, Wolvers MDJ, and Wyers CE

Subjects
Age Factors, Aged, Comorbidity, Critical Care methods, Critical Care statistics & numerical data, Female, Hospital Mortality, Humans, Kaplan-Meier Estimate, Male, Netherlands epidemiology, Risk Factors, Severity of Illness Index, COVID-19 epidemiology, COVID-19 prevention & control, COVID-19 therapy, Cardiovascular Diseases epidemiology, Diagnostic Tests, Routine methods, Diagnostic Tests, Routine statistics & numerical data, SARS-CoV-2 isolation & purification
Abstract

Objective: To systematically collect clinical data from patients with a proven COVID-19 infection in the Netherlands., Design: Data from 2579 patients with COVID-19 admitted to 10 Dutch centers in the period February to July 2020 are described. The clinical data are based on the WHO COVID case record form (CRF) and supplemented with patient characteristics of which recently an association disease severity has been reported., Methods: Survival analyses were performed as primary statistical analysis. These Kaplan-Meier curves for time to (early) death (3 weeks) have been determined for pre-morbid patient characteristics and clinical, radiological and laboratory data at hospital admission., Results: Total in-hospital mortality after 3 weeks was 22.2% (95% CI: 20.7% - 23.9%), hospital mortality within 21 days was significantly higher for elderly patients (> 70 years; 35, 0% (95% CI: 32.4% - 37.8%) and patients who died during the 21 days and were admitted to the intensive care (36.5% (95% CI: 32.1% - 41.3%)). Apart from that, in this Dutch population we also see a risk of early death in patients with co-morbidities (such as chronic neurological, nephrological and cardiac disorders and hypertension), and in patients with more home medication and / or with increased urea and creatinine levels., Conclusion: Early death due to a COVID-19 infection in the Netherlands appears to be associated with demographic variables (e.g. age), comorbidity (e.g. cardiovascular disease) but also disease char-acteristics at admission.

Published
2021

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