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Acrylates can be the causative allergen in contact dermatitis to adhesives on the skin. The presence of acrylates in the adhesive, however, has to be confirmed. We present a case of an 81-year old male who developed contact dermatitis on his lower back at the same site where Transcutaneous electrical nerve stimulation (TENS) was applied continously for three years. Despite positive patch test reactions to several (meth)acrylates,they were not found to be present in the adhesive layer of the electrodes. Additional patch testing with the ingredients of the adhesive layer according to the material safety data sheet (MSDS), with extracts of the electrodes, and with thin-layer chromatograms were performed. The patient showed a positive patch test reaction to acrylic acid, and its presence in the electrode was confirmed with high-pressure liquid-chromatography-UV (HPLC-UV). A TENS electrode that did not contain either (meth) acrylates or acrylic acid was prescribed, after which the dermatitis disappeared.

Acrylates can be the causative allergen in contact dermatitis to adhesives on the skin. The presence of acrylates in the adhesive, however, has to be confirmed. We present a case of an 81-year old male who developed contact dermatitis on his lower back at the same site where Transcutaneous electrical nerve stimulation (TENS) was applied continously for three years. Despite positive patch test reactions to several (meth)acrylates,they were not found to be present in the adhesive layer of the electrodes. Additional patch testing with the ingredients of the adhesive layer according to the material safety data sheet (MSDS), with extracts of the electrodes, and with thin-layer chromatograms were performed. The patient showed a positive patch test reaction to acrylic acid, and its presence in the electrode was confirmed with high-pressure liquid-chromatography-UV (HPLC-UV). A TENS electrode that did not contain either (meth) acrylates or acrylic acid was prescribed, after which the dermatitis disappeared.

Acrylates can be the causative allergen in contact dermatitis to adhesives on the skin. The presence of acrylates in the adhesive, however, has to be confirmed. We present a case of an 81-year old male who developed contact dermatitis on his lower back at the same site where Transcutaneous electrical nerve stimulation (TENS) was applied continously for three years. Despite positive patch test reactions to several (meth)acrylates,they were not found to be present in the adhesive layer of the electrodes. Additional patch testing with the ingredients of the adhesive layer according to the material safety data sheet (MSDS), with extracts of the electrodes, and with thin-layer chromatograms were performed. The patient showed a positive patch test reaction to acrylic acid, and its presence in the electrode was confirmed with high-pressure liquid-chromatography-UV (HPLC-UV). A TENS electrode that did not contain either (meth) acrylates or acrylic acid was prescribed, after which the dermatitis disappeared.

OBJECTIVE: To determine the effect of the warning by the Dutch Medicines Evaluation Board (CBG) in 2004 concerning SSRI use by children on the trend of SSRI utilization in the Dutch population in the period 1998-2010. DESIGN: Interrupted time series analysis. METHODS: Yearly prevalence of SSRI utilization (excluding fluoxetine) was calculated for the age categories 12-18, 19-24, 25-49, 50-64 and 65-84 years. Regression was used to determine whether the trend in SSRI utilization after 2004 changed significantly from the trend before 2004. RESULTS: Prevalence in SSRI utilization in age groups 12-18, 19-24 and 25-49 years increased in the period 1998 to 2004 and started to decline after 2004 (P

OBJECTIVE: To determine the effect of the warning by the Dutch Medicines Evaluation Board (CBG) in 2004 concerning SSRI use by children on the trend of SSRI utilization in the Dutch population in the period 1998-2010. DESIGN: Interrupted time series analysis. METHODS: Yearly prevalence of SSRI utilization (excluding fluoxetine) was calculated for the age categories 12-18, 19-24, 25-49, 50-64 and 65-84 years. Regression was used to determine whether the trend in SSRI utilization after 2004 changed significantly from the trend before 2004. RESULTS: Prevalence in SSRI utilization in age groups 12-18, 19-24 and 25-49 years increased in the period 1998 to 2004 and started to decline after 2004 (P

OBJECTIVE: To determine the effect of the warning by the Dutch Medicines Evaluation Board (CBG) in 2004 concerning SSRI use by children on the trend of SSRI utilization in the Dutch population in the period 1998-2010. DESIGN: Interrupted time series analysis. METHODS: Yearly prevalence of SSRI utilization (excluding fluoxetine) was calculated for the age categories 12-18, 19-24, 25-49, 50-64 and 65-84 years. Regression was used to determine whether the trend in SSRI utilization after 2004 changed significantly from the trend before 2004. RESULTS: Prevalence in SSRI utilization in age groups 12-18, 19-24 and 25-49 years increased in the period 1998 to 2004 and started to decline after 2004 (P