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This study aims to make a significant contribution to the development of a model for integrating research in the wine sector, innovative knowledge, and family businesses with the traditional mode of production in the context of the introduction of modern production technologies with a view to sustainability and the improvement of services in tourism. From a methodological point of view, the research is based on the case study and, in particular, on Casa Paladin, a family business in the Italian wine sector, which bases its strategy on innovation in production processes and customer relations to obtain high product quality with the aim of meeting consumer needs. The findings underscore the crucial role of family businesses in preserving cultural and traditional elements in the wine sector, with technology and innovation serving as vital drivers for their development. Casa Paladin's commitment to innovation in production processes and products is evident, emphasizing sustainability as a core element that impacts customer relationships and product quality. Enotourism, including tastings, festivals, and fairs, emerges as a significant aspect contributing to the promotion of the company's history, culture, and traditions. This study posits Casa Paladin as a notable example in the Italian wine industry, offering transferable insights for other businesses. Its successful integration of culture, innovation, and sustainability contributes to a broader understanding of the contemporary role of family businesses in the Italian wine sector. [ABSTRACT FROM AUTHOR]

Environmental, Social and Governance (ESG) issues have become particularly relevant in the agendas of policymakers, investment decisions by companies and asset allocation process of investors. However, the transition to a greener and more sustainable economic system is not without risks. The literature has investigated the relationship between ESG and risk in different ways, through multiple perspectives and approaches. We select all documents with "ESG" and "Risk" in the title, abstracts and keywords available in Scopus and, after removing non‐relevant papers, we are left with a sample of 589 documents published in the period 1983–2022. To provide a view of the most important studies, we also focus on the most cited documents to discuss the methodological approaches and main results. The results show that over time, ESG has gained increasing attention from the literature, but researchers work in isolation and there is no single approach or leading core topic driving academic productivity; a clear taxonomy of ESG risks appears to be missing. To the best of our knowledge, this paper is the first to discuss research on ESG and risk from a financial perspective. The results highlight some existing gaps in the literature that can provide a hint for the development of the topic by researchers. These include a clearer taxonomy of ESG risks that can affect investors' and companies' decisions, a greater effort to evaluate how ESG risks distribute and spill from one sector to another and the inclusion of emerging economies and small and medium‐sized enterprises in the samples. [ABSTRACT FROM AUTHOR]

Corporate social responsibility (CSR) and fiscal responsibility have become a hot topic of debate in recent years. Many studies have investigated CSR and tax avoidance; however, such studies have overlooked countries' tax cultures and fiscal responsibility from a historical perspective and have not addressed how these elements affect current tax avoidance practices. Using a questionnaire, that was administered to a sample of Italian and Romanian respondents, and inferential techniques (Mann–Whitney‐test and correlation‐test) the paper tries to understand the aspects that be useful in the future development and implementation of more robust fiscal ISR and CSR processes. Our results reveal similarities and differences between the relevance of certain aspects between countries, identifying tax culture as a distinctive element from a geographical point of view. Despite the considerable differences, we found a strong demand for greater transparency of the company with administrations and communities and desire for the development of initiatives to spread a responsible tax culture. [ABSTRACT FROM AUTHOR]

Resilience and the efficiency of transportation systems are crucial for the economic development of geographical areas, and network analysis applied to railways can provide insight into the importance of branch lines and their impacts on the entire system. This paper explores the behavior of the ERC measure, a local robustness measure, on the railway network in Lombardy, Italy, and analyzes the impacts of deactivating stations or journeys on the network's robustness. Changes in the topological properties of the network were studied by simulating potential external disturbances and analyzing the impact of deleting the most connected stations or railway lines. The numerical results show how the measures provided effectively identify critical stations and journeys within the network structure and outperform classical topological metrics. Since ERC measures take into account all of the alternative paths present in the network, they can provide valuable information for rerouting traffic along alternative paths in case of failures or disruptions. The paper's original contribution lies in demonstrating the effectiveness of the ERC measure in identifying critical stations and journeys within the network structure. [ABSTRACT FROM AUTHOR]

The aim of this study is to describe and analyse the relationship between the phenomenon of B Corp and M&A operations carried out by these companies. Italy is the second country at the international level and the first country at the European level to have been particularly active in this direction (Law n.208/2015). Therefore, a questionnaire was developed and sent to the certified Italian B Corps. The medium‐long‐term vision emerged in particular, and the values that guide these companies are ethics, sustainability and transparency. These are aspects that particularly characterise the ideals, identity and culture of B Corps, which are also involved in social and environmental issues. The research shows how corporate culture influences these companies from a merger and acquisition perspective. Cultural compatibility is important, as it allows the companies to operate according to common or similar visions regarding certain aspects that other companies probably find less important. [ABSTRACT FROM AUTHOR]

The symmetric shock of the Covid-19 pandemic has come with heterogeneous consequences across the world. Within the common institutional framework of the European Union, the outbreak has put under extreme stress governance and interplay between the national and supranational level. Under some coordination, responses have remained largely in the hands and on the shoulders of the Member States. In this context, the article classifies pandemic outbreaks and responses along the containment and fiscal support dimensions to uncover whether a common model for Covid-19 crisis management arises across the EU27 or rather different policy choices patterns emerge within the continent. Based on indicators covering the three dimensions derived from the Oxford Covid Government response tracker, the John Hopkins CSSE Covid-19 database and the European Commission Autumn Forecasts, the paper employs hierarchical cluster analysis to uncover response group across countries and characterize them by the outbreak, containment and fiscal support strengths, delineating as well the geographical distribution across and within the clusters. The findings present the heterogeneity of response models, robust to alternative specifications and timeframes across the first and the second wave, deriving broader implications for the outlook for the vaccine-roll out and exit from the crisis. The dynamics in 2020 are also considered in the context of the shortcomings of supranational governance within the EU and the current policy reform debate, highlighting the high stakes for the upcoming Conference on the Future of Europe. The contribution of the work is furthered by offering a systematic methodology and framework to study heterogeneities of pandemic responses within the EU paving the way for further analysis of contributing factors explaining decision-makers policy choices as well as performance concerning political, social and economic outcomes across the models. [ABSTRACT FROM AUTHOR]

Religious tourism and pilgrimages increasingly contribute to developing the social and economic growth of local economies and communities over time. The aim of the present study is to analyse the role of religious touristic routes as sites of pilgrimages and an opportunity to drive a pathway for sustainable tourism development. The study relies on analysing qualitative and quantitative data, through a questionnaire distributed in late 2018; the questionnaire relates to pilgrimages concerning the Camino de Santiago de Compostela and Via Francigena as religious touristic destinations that contribute to the social and economic sustainability of local economies. Indeed, these pilgrimages strengthen the importance of building collaborative processes by enabling religious touristic destinations to open up to better managing and by driving sustainability‐oriented policies, thus enhancing social and economic growth within local communities. [ABSTRACT FROM AUTHOR]

A Benefit Corporation is one possible alternative to traditional business models and a new way of managing business and sustainability. Emphasis on B‐Corporations in Italy dates back 2006, and 1 year later, B LAB certified the first Benefit Corporation Industry using the first version of the Benefit Impact Assessment process. Since then, the number of B‐Corporations has been growing, showing the success of the initiative of this category of firm that have voluntarily decided to pursue, like the profit, a further purpose: to obtain in the exercise of economic activity a positive impact on society and on the planet. After a presentation of the Benefit Corporation features, the main aim of this paper is to explore the relations that exists between the five different impact areas considered in certification awarded to Certified Benefit Corporation and the net profit value, using ordinary least squares regression model based on the entire sample of the Italian Certified enterprises. [ABSTRACT FROM AUTHOR]

This article aims to evaluate the market performance of the European tourism industry from 2004 to 2014, a period that includes the financial and economic crises, to highlight which macroeconomic factors influenced the industry stock returns. The Stoxx Europe 600 Travel & Leisure price index is used to proxy the industry stock performance, and a multifactor market model is employed to individuate which macroeconomic variables are able to drive tourism stock performance. Results highlight that tourism stock performance is influenced by market conditions and by uncertainty, measured through the Chicago Board Options Exchange Volatility index (VIX). Despite the importance of tourism in Europe and its contribution to the economic growth, there is scant evidence on the performance of this industry in this area and on its relationship with economic conditions. The article, to the best of knowledge, represents the first contribution on the performance of European tourism industry in crisis years with a macroeconomic perspective. [ABSTRACT FROM AUTHOR]

Web applications are among the most popular and relevant kinds of application. Most Web applications are developed using a content management framework (CMF). CMF helps to accelerate the publication of large amounts of information and the development of Web applications. However, developing Web applications through CMF is not exempt from cost and time overruns, as in traditional software projects. Currently, there is no estimation model able to adequately measure the effort of developing a Web application. This work presents a new methodology, called web framework points, to estimate the effort of Web applications developed with CMF. Web framework points is a hybrid methodology, composed of a sizing phase, which follows specific guidelines, and an effort estimation phase, obtained by applying a cost model to the size model of the project to estimate. The sizing of the project takes into account not only usual functional requirements, as in function points analysis, but also elements specific for developing a Web application through CMF. We also present the experimental validation of the proposed methodology, performed on a dataset of 29 real-world projects, of which 83% show an estimation error of less than 25%. Copyright © 2015 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

The retail sector, under the pressure of digitalization and technological innovation, has experienced profound changes in the last decade, and retailers have had to cope with these changes by implementing new business models and competitive strategies with the aim of satisfying the consumers' needs. In the last few decades, the sector has been affected by different new trends, from the birth of supermarkets to the advent of e-commerce, up to the introduction of cashierless stores. The latter represents a new category of store that is totally computer-based and digitalized, in which the use of cameras, sensors and self-shelves minimizes human interaction. Amazon pioneered this emerging concept, with the launch of Amazon Go, but other start-up companies are rapidly entering the cashierless retail market and embracing the challenge. The purpose of this paper is to analyze the knowledge of Italian consumers of cashierless shops, and the relevance of different factors related to this new kind of shops. A questionnaire was sent to a sample of more than 1000 consumers to identify and evaluate the actual situation and knowledge of this phenomenon, which is not yet diffuse in Italy. A statistical analysis, regarding both their knowledge about cashierless stores and the customer experience, is provided to discuss the most relevant factors affecting the customers' perceptions and attitudes, with a comparison per gender and type of users. The results of the provided analysis reveal that the phenomenon is very little known, and this is certainly influenced by the lack of these stores in Italy. [ABSTRACT FROM AUTHOR]

In 71 adults residing in Florence, Italy, enrolled in a prospective study, we investigated the correlation between individual levels of oxidative DNA damage detected by the Comet assay in circulating lymphocytes, and a specific ozone exposure score calculated in 10 different time-windows (0–5 to 0–90days) before blood drawing, based on daily measurements provided by the local environmental monitoring system. Overall, statistically significant positive correlations between average ozone concentrations and DNA damage emerged in almost all time-windows considered; correlations were more evident among males, non-smokers, and traffic-exposed workers. Multivariate regression analyses taking into account selected individual characteristics, showed an independent effect on DNA damage of average ozone concentrations in the last 60–90days before blood drawing. Local residents showed a divergent pattern with correlations restricted to shorter time-windows. Our results suggest that ozone concentrations at ground levels modulate oxidative DNA damage in circulating lymphocytes of residents of polluted areas. [Copyright &y& Elsevier]

The benzo[ a ]pyrene temporal trend was investigated in 11 towns where at least five annual means were available. The overall number of stations was 22, of which 12 were traffic-oriented, 6 background and 4 industrial. The trend was generally declining at traffic-oriented sites and roughly stable at background sites. The annual means in 2004 still exceeded the forthcoming European target value of 1 ng/m 3 in two towns (up to 1.9 ng/m 3 ). The background means (up to 1.4 ng/m 3 in 2004) accounted for approximately 40–90% of those at the traffic-oriented sites in the same town. The presence of a coke plant was incompatible with the attainment of the target value, while the adoption of technical measures on a carbon electrode plant was successful in attaining concentrations lower than the target value. In heavy traffic areas in Italy, the attainment of the target value hardly appears feasible under the current conditions of traffic congestion. [ABSTRACT FROM AUTHOR]

The paper aims at investigating the impact of UN Sustainable Development Goals (SDGs) 2030 on Italian "public interest entities" both in term of approaches to non-financial disclosure and on business strategies. The analysis focuses on the investigation of the relationships between the 17 SDGs and the set of non-financial information defined in bont the EU Directive 2014/95/EU and the related Italian L.D. n. 254 of 30 December 2016. SDGs has been significantly analysed in the literature, considering the effects on sustainability policies adopted by the States, but little attention has been paid to the policies adopted by companies. The awareness of companies towards the business implication connected to the achievemt of these goals translate into a new conscientious path, in compliance with sustainability standards. In this framework, the paper investigates the entire population of Italian companies subject to the publishing of non-financial information disclosure, with the exclusion of banks and insurance companies. For each company under investigation, two kinds of analysis are presented: (1) firstly, the company's level of sustainability derived from the company website; (2) the approach in pursuing the 17 SDGs. The overall results are quite comforting in term of companies' sustainability aptitude. Over the years, Italian public interest entities have implemented active policies linked to the achievement of some specific goals, in compliance with the Italian legislation, although divergences still emerge among the Italian areas, as a result of cultural differences that still exist and affect companies' approaches to sustainability issues. In this regard, the results of the analysis are interesting for government authorities to regulat the pursuit of sustainability goals. [ABSTRACT FROM AUTHOR]

The significant changes which have occurred in the competitive scenario in which fashion companies operate, combined with deep transformation in the lifestyles of final consumers, translate into the need to redefine the business models. Starting from a general overview of the emerging trends today affecting the fashion industry, the paper will devote particular attention to the analysis of the most important phenomena that are influencing this market and the drivers for long-lasting competitiveness: sustainability and attention to the so-called circular economy. According to the literature, from the consumer behavior's point of view, the younger generations are paying growing attention to these issues. In light of these considerations, this paper aimed to analyze how sustainability and circular economy principles are influencing the perception of the fashion world among the new generations of consumers. After mapping the emerging trends in the fashion industry and analyzing the role of sustainability from both the demand and supply side, this paper presents the results of a survey conducted through an anonymous questionnaire made in collaboration with Insubria University. The results of the survey describe the students' behaviour as regards fashion's emerging trends, with particular attention to sustainability issues and the application of circular economy principles. The survey results were analyzed from both a descriptive and quantitative point of view with the aim to check the different perceptions as regards sustainable fashion and circular economy in fashion, focusing mainly on the so-called Generation Z. The results of the analysis proved to be consistent with the theoretical framework and confirm the relevance of sustainability issues in the fashion industry today in driving the demand of Generation Z, by considering a gender perspective. Moreover, the circular economy is descriptively analyzed with the aim to understand the relevance of the different facets for the entire sample of respondents. [ABSTRACT FROM AUTHOR]

One form of cycle tourism can be represented features tourism that focuses on the relation between biking and the discovery of a territory. Geared toward forms of holiday that allow for the low consumption of natural resources and a connection with the landscape, cycle tourism represents a concrete expression of sustainable tourism. As an emerging phenomenon in Italy, cycle tourism requires further understanding in order to identify methods of development and applicable business models. The aim of this paper is to explore the characteristics of cycle tourism’s development in northern Italy in order to identify the links that exist between sustainability and the group of cycle tourists who prefer to spend their holidays discovering little-known or remote territories. For this study, we selected three different destinations in sensitive mountain areas that converge on the common goal to use cycling to rejuvenate the tourism sector. It has been found that the development of cycle tourism in areas not characterized by mass tourism, such as those considered here, is economically, socially, and environmentally beneficial. The business models through which cycle tourism usually develops include a bottom up approach or a top down approach, involving the cooperation of several local destination stakeholders. [ABSTRACT FROM AUTHOR]

This paper investigates whether or not Italian Certified B Corps® in the fashion industry achieved levels of corporate social responsibility (CSR) and financial performance that are comparable to listed companies in the same industry during the Covid-19 pandemic. After a review of the literature concerning B Corps, CSR and the circular economy, as well as some coverage of pandemic impacts, a quantitative approach is used to analyze the data empirically. Based on the data available, the study incorporated the entire population of Italian listed companies and B Corps in the fashion industry. Moreover, this study confirms the relationship between CSR and financial performance. The availability of sustainability documents other than the required social responsibility report does not directly affect a company's profitability, but they are necessary for the long term. The results also confirm the positive relationship between sustainability certification and higher financial performance, as the most sustainable companies were also the most profitable. Certified B Corps® declare their willingness to adopt circular economic principles to the same extent as non-certified listed companies. Moreover, the results show that consumers mainly remember the information disclosed on a company's homepage; therefore, managers should publish more there. However, they should not underestimate the importance of their sustainability report because it is an effective social communication tool, especially in the long term. Finally, obtaining the B Corp certification will allow companies to inform stakeholders of their social responsibility and achieve higher financial results. [ABSTRACT FROM AUTHOR]

Abstract: Objective: Personal exposure to airborne benzene is influenced by various outdoor and indoor sources. The first aim of this study was to assess the benzene exposure of a sample of urban inhabitants living in an inner-city neighborhood of Florence, Italy, excluding exposure from active smoking. The secondary objective was to differentiate the personal exposures according to personal usage patterns of the vehicles. Methods: A sample of 67 healthy non-smokers was monitored by passive samplers during two 4-weekday campaigns in winter and late spring. Simultaneously, benzene measurements were also taken for a subset of participants, inside and outside their houses. A 4-day time microenvironment activity diary was completed by each subject during each sampling period. Other relevant exposure data were collected by a questionnaire before the sampling. Additional data on urban ambient air benzene levels were also available from the public air quality network. The passive samplers, after automated thermal desorption, were analyzed by GC-FID. Results: Benzene personal exposure levels averaged 6.9 (SD=2.1) and 2.3 (SD=0.7) μg/m3 in winter and spring, respectively. Outdoor and indoor levels showed high correlation in winter and poor in spring. In winter the highest benzene personal exposure levels were for people traveling by more public transport, followed by users of only car and by users of only bus respectively. Conclusions: The time spent in-transport for work or leisure makes a major contribution to benzene exposure among Florentine non-smoking citizens. Indoor pollution and transportation means contribute significantly to individual exposure levels especially in winter season. [Copyright &y& Elsevier]

On October 2004, a sampling survey was carried out in Florence to estimate urban fine particle exposure concentrations inside commuting vehicles during workdays characterized by heavy traffic. Portable samplers were positioned inside four regularly scheduled diesel-powered buses and four taxis during eight weekdays. Each sampler consisted of a 2.5μm size pre-separator cyclone, a direct-reading data logging photometer (pDR-1200), and a 4Lmin−1 filter sampler for the determination of PM2.5 mass concentration. Based on reflectance analysis measurements, a PM2.5 Black Smoke Index was determined for each filter, and the elemental composition of the PM2.5 was analyzed by Particle Induced X-ray Emission (PIXE). PM2.5 mass concentrations inside the vehicles correlated well with the urban ambient air PM2.5 concentrations measured at the fixed-site monitoring stations. The PM2.5 excess above the urban ambient level was on average 32μgm− 3 (range: 22–52μgm− 3) and 20μgm− 3 (range: 11–29μgm− 3) in buses and taxis, respectively. The PM2.5-bound sulfur concentration was also higher in the buses than in the taxis. Based on daily Time-Microenvironment-Activity-Diary (TMAD) data, the Florentines spend on average 9.7% of their day in traffic, and the corresponding average exposure is approximately 12% of their daily PM2.5 personal exposure. The obtained data could be used to plan interventions to minimize the PM2.5 citizen exposures in commuting. [Copyright &y& Elsevier]

Air pollution and particulate matter in urban areas have been associated with increased mortality from cardiovascular and respiratory diseases and increased cancer risk. Carcinogenic effects of particulate matter have been related to the contents of specific compounds, such as polycyclic aromatic hydrocarbons. The latter may form bulky DNA adducts, that may be considered as candidate markers of cancer risk. We have recently shown that traffic-exposed workers and the general population in Florence have divergent levels of DNA adducts, possibly related to different levels of exposure to genotoxic agents from vehicle emissions. In the current study, in a series of 214 Florence City healthy adults enrolled in a prospective study in the period 1993–1998 (152 residents / 62 traffic-exposed workers), we investigated the correlation between individual levels of DNA bulky adducts and PM10 exposure scores based on daily environmental measures provided by the local Environmental Protection Agency for the whole study period, by two types of urban monitoring stations (high- and low-traffic). We found that PM10 cumulative scores from high-traffic stations over the last 1–2 weeks prior to blood drawing significantly correlated (r =0.58, p =0.02) with DNA adduct levels among non-smoking traffic-exposed workers (but not among residents with no occupational exposure to vehicle emissions). A multivariate regression analysis adjusted for possible confounders confirmed these findings. PM10 scores from low-traffic stations did not show any correlation. These results show that DNA adduct levels in non-smoking workers reflect the average levels of exposure to PM10 in high-traffic urban areas experienced over a time period of 1–2 weeks. Since DNA adduct levels have been found predictive of lung cancer risk, our findings provide clues relevant to the reduction of genotoxic damage and possibly cancer risk among traffic-exposed urban workers. [Copyright &y& Elsevier]

Abstract: Prior to 2000 a network of conventional ozone (O3) analysers existed in the Province of Firenze (Tuscany, central Italy). Between 2000 and 2004 the network was extended to incorporate a newly designed bioindicator network of tobacco plants (Nicotiana tabacum Bel W3). The objective was to set-up an integrated monitoring system to obtain estimates of ground-level O3 concentrations over the whole study area (3513 km2) in order to fill data gaps and cover reporting requirements. The existing conventional monitors were purposefully located mainly in urban areas. A total of 45 biomonitoring sites were selected using a systematic design to cover the target area. Two to five additional biomonitoring sites were co-located with conventional O3 analysers for calibration purposes, and five more sites for independent validation of modelled O3 concentrations. Visible Leaf Injury Index (LII) on the tobacco plants was significantly correlated (P: 0.018÷0.0014) with a series of O3 exposure variables (mean of weekly 1-hour maxima, M1; mean of 7-hour means, M7; 24-hour mean, M24; and weekly AOT40). LII was found to be a significant predictor of weekly means of the O3 exposure variables with a standard error of estimates between 13.6 and 24.3 μg m−3 (absolute values). LII was mapped with an ad-hoc spatial model over the study area at a 2⁎2 km grid resolution, and mapped values were used to predict O3 concentrations by means of a first order linear model. Results showed that high estimates of O3 (up to 188 μg m−3 as mean of weekly maxima, M1) occurred more frequently in hilly and mountainous areas, with a spatial pattern changing on an annual basis. Predicted O3 concentrations were not significantly different from the measured concentrations (P: 0.34), although marked differences were observed for individual sites and years. The study provided evidence that integration of monitoring networks using different methods can be a viable option to obtain estimates of O3 concentrations over large areas. [Copyright &y& Elsevier]

Air pollution and particulate matter in urban areas have been associated with increased mortality from cardiovascular and respiratory diseases and increased cancer risk. Carcinogenic effects of particulate matter have been related to the contents of specific compounds, such as polycyclic aromatic hydrocarbons. The latter may form bulky DNA adducts, that may be considered as candidate markers of cancer risk. We have recently shown that traffic-exposed workers and the general population in Florence have divergent levels of DNA adducts, possibly related to different levels of exposure to genotoxic agents from vehicle emissions. In the current study, in a series of 214 Florence City healthy adults enrolled in a prospective study in the period 1993-1998 (152 residents / 62 traffic-exposed workers), we investigated the correlation between individual levels of DNA bulky adducts and PM(10) exposure scores based on daily environmental measures provided by the local Environmental Protection Agency for the whole study period, by two types of urban monitoring stations (high- and low-traffic). We found that PM(10) cumulative scores from high-traffic stations over the last 1-2 weeks prior to blood drawing significantly correlated (r=0.58, p=0.02) with DNA adduct levels among non-smoking traffic-exposed workers (but not among residents with no occupational exposure to vehicle emissions). A multivariate regression analysis adjusted for possible confounders confirmed these findings. PM(10) scores from low-traffic stations did not show any correlation. These results show that DNA adduct levels in non-smoking workers reflect the average levels of exposure to PM(10) in high-traffic urban areas experienced over a time period of 1-2 weeks. Since DNA adduct levels have been found predictive of lung cancer risk, our findings provide clues relevant to the reduction of genotoxic damage and possibly cancer risk among traffic-exposed urban workers.

Ozone (O(3)), the major oxidant component in photochemical smog, mostly derives from photolysis of nitrogen dioxide. O(3) may have biologic effects directly and/or via free radicals reacting with other primary pollutants and has been reported to influence daily mortality and to increase lung cancer risk. Although DNA damage may be caused by ozone itself, only other photochemical reaction products (as oxidised polycyclic aromatic hydrocarbons) may form bulky DNA adducts, a reliable biomarker of genotoxic damage and cancer risk, showing a seasonal trend. In a large series consisting of 320 residents in the metropolitan area of Florence, Italy, enrolled in a prospective study for the period 1993-1998 (206 randomly sampled volunteers, 114 traffic-exposed workers), we investigated the correlation between individual levels of DNA bulky adducts and a cumulative O(3) exposure score. The average O(3) concentrations were calculated for different time windows (0-5 to 0-90 days) prior to blood drawing for each participant, based on daily measurements provided by the local monitoring system. Significant correlations between DNA adduct levels and O3 cumulative exposure scores in the last 2-8 weeks before enrollment emerged in never smokers. Correlations were highest in the subgroup of never smokers residing in the urban area and not occupationally exposed to vehicle traffic pollution, with peak values for average concentrations 4-6 weeks before enrollment (r = 0.34). Our current findings indicate that DNA adduct formation may be modulated by individual characteristics and by the cumulative exposure to environmental levels of ozone in the last 4-6 weeks, possibly through ozone-associated reactive pollutants., (Copyright 2003 Wiley-Liss, Inc.)