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Rapidly developing single-cell sequencing analyses produce more comprehensive profiles of the genomic, transcriptomic, and epigenomic heterogeneity of tumor subpopulations than do traditional bulk sequencing analyses. Moreover, single-cell techniques allow the response of a tumor to drug exposure to be more thoroughly investigated. Deep learning (DL) models have successfully extracted features from complex bulk sequence data to predict drug responses. We review recent innovations in single-cell technologies and DL-based approaches related to drug sensitivity predictions. We believe that, by using insights from bulk sequence data, deep transfer learning (DTL) can facilitate the use of single-cell data for training superior DL-based drug prediction models. A comprehensive understanding of heterogeneous tumor subpopulations will benefit drug sensitivity prediction and combination drug treatment design. Deep learning models are powerful and extensively used in drug sensitivity prediction and in inferring drug–target interactions. Single-cell sequencing techniques offer precise and accurate profiling of tumor subpopulations and reveal subtle differences in their response to drug treatments. Applying deep transfer learning to predict drug sensitivity allows us to not only take advantage of prior knowledge obtained from massive bulk sequencing data but also utilize the heterogeneous landscapes generated by single-cell sequencing techniques. The integration of single-cell multi-omic data for drug sensitivity prediction using transfer learning methods poses a special challenge. [ABSTRACT FROM AUTHOR]

Bearing fault diagnosis suffers from class imbalances and distributional discrepancies of fault data under different working conditions. The class imbalance of the fault class increases the difficulty of learning the classification boundary of the diagnostic model for the minority class. Furthermore, the diversities of feature distributions decrease the diagnostic model's generalizability under various working conditions. Thus, in this paper, a deep adversarial transfer learning model for imbalanced bearing fault diagnosis (deep Imba-DA) is proposed to overcome these problems. In the proposed method, a cost-sensitive deep classifier is used to solve the class imbalance problem, and the domain adversarial subnet with the intraclass maximum mean discrepancy (MMD) is used to minimize the marginal and conditional distributional discrepancy between the source (data under one working condition) and target domain (data under another working condition) simultaneously. The performance of deep Imba-DA is evaluated and analyzed on the Case Western Reserve University (CWRU) and Paderborn datasets. The results show that deep Imba-DA outperforms other baseline methods on bearing diagnostic tasks. • An imbalanced bearing fault diagnostic model under variant conditions is proposed. • A joint transfer network with marginal and conditional distribution is developed. • Pseudo label strategy guarantees a good accuracy and fast convergence. [ABSTRACT FROM AUTHOR]

• We utilize parallel sub networks to automatically reveal saliency clues at different spatial levels. • We propose an end-to-end salient object detection model that learns diversity saliency clues in an iterative manner. • We also provide a novel selective fusion strategy to fuse multi-model saliency clues for a high-performance salient object detection. Fully convolutional networks have shown outstanding performance in the salient object detection (SOD) field. The state-of-the-art (SOTA) methods have a tendency to become deeper and more complex, which easily homogenize their learned deep features, resulting in a clear performance bottleneck. In sharp contrast to the conventional "deeper" schemes, this paper proposes a "wider" network architecture which consists of parallel sub-networks with totally different network architectures. In this way, those deep features obtained via these two sub-networks will exhibit large diversity, which will have large potential to be able to complement with each other. However, a large diversity may easily lead to the feature conflictions, thus we use the dense short-connections to enable a recursively interaction between the parallel sub-networks, pursuing an optimal complementary status between multi-model deep features. Finally, all these complementary multi-model deep features will be selectively fused to make high-performance salient object detections. Extensive experiments on several famous benchmarks clearly demonstrate the superior performance, good generalization, and powerful learning ability of the proposed wider framework. [ABSTRACT FROM AUTHOR]

Ultrasonic testing (UT) is commonly used to inspect the geometric shape of internal damage in composite materials and the test results need to be interpreted by trained experts. In this work, an automatic signal classification method based on deep learning is proposed for depth estimation of the detects introduced by low-velocity impact (LVI) in carbon fiber reinforced plastics (CFRPs). Three kinds of neural networks, LSTM, CNN, and CNN-LSTM are used to analyze the attributes with different depths. Then, trained models are applied to identify the depth information of impact damage. The results show that the CNN-LSTM model is a more accurate in-depth classification for LVI defects in CFRP based on A-scan signals than the other two structures. [ABSTRACT FROM AUTHOR]

• A modified-YOLOv5s was proposed to detect defects of wire braided hoses. • K-means++ clustering algorithm is adopted to obtain more suitable anchor boxes. • Focal loss function was adopted to balance between negative and positive samples. • New tailored prediction heads and efficient channel attention (ECA) mechanism were used to improve the detection performance. High-pressure steel wire braided hoses have periodic braided steel wire structure and its productivity is too huge to refrain from making mistakes occasionally such as wire missed wire stacked and wire loosened. The major sticking points in detection are ultra-small, structural similarity and high reflectance of the steel wire braided hoses. Therefore, this paper proposed an automated method based on YOLOv5 to replace traditional naked eyes detection. The anchor boxes were optimized by K-means++ algorithm for defects dataset. Focal loss was used to mitigate the impact of samples imbalance. The predict heads were modified to increase the detection accuracy of ultra-small targets with guaranteeing speed. The effect of efficient channel attention mechanism (ECA) in different positions was analyzed to achieve a better network and increase detection performance. The experimental results showed that the accuracy and recognition efficiency of the proposed modified-YOLOv5s model could reach 92.2% and 23 frames per second. [ABSTRACT FROM AUTHOR]

• A temperature component is given by theoretical inference and parameter optimization. • Separate modeling technique is proposed based on ICEEMDAN and clustering analysis. • The ET-SMT-DELM model is established by a multi-output deep extreme learning machine. • The proposed model has high accuracy, credibility and interpretability. The anatomy of service status through health monitoring models is essential to long-term structural safety. Since deformation is the intuitive representation of the dam's operating condition, it is crucial to investigate the deformation monitoring model with high accuracy and strong interpretability for the safety management of high arch dams. A novel deformation monitoring model is proposed by incorporating impulse response-based equivalent temperature (ET) and machine learning-aided separate modeling technique (SMT). This methodology has three main sources of novelty. First, the impulse response-based equivalent temperature and corresponding temperature component are derived from heat transfer and temperature convolution theories. Then, the model parameters are identified by an improved firefly algorithm. Second, the components in the monitored displacement are progressively stripped out by clustering analysis, separation under equal water level conditions, and a robust signal decomposition technique. Third, the separated deformation components and environmental factors are modeled by the multi-output deep extreme learning machine (DELM) with autoencoder, and the monitoring model ET-SMT-DELM is thus established. The world's highest arch dam is selected to illustrate the proposed model, and the prediction accuracy, early warning performance, component shares, and impulse response mechanism are comprehensively investigated by comparing with several typical baseline models. The results show that the overfitting of the proposed model is reduced, and the prediction and early warning performance is significantly improved. The resulting temperature impulse response function and component shares imply that the interpretability of the model is also enhanced. [ABSTRACT FROM AUTHOR]

Accurate 3D representations of multiphase layered composite fabric, including distinguish and label the pores, matrices, warp and weft yarns, can assist in understanding and ultimately improving composite material design performance. In this work, a new data enhancement algorithm is proposed to generate realistic-looking artificial learning datasets for expanding the datasets. Then, we demonstrate how supervised, the Swin Transformer approach can help to realize accurate segmentation of low-resolution and poor-contrast fabric datasets by populating databases with real and artificial learning datasets. Most of the pixels were correctly identified and the boundaries of the yarn could be identified clearly, except for some spots and a few merged boundaries. The work presented here provides an effective tool that can be widely used in semantic segmentation for various composite materials (woven composites, fiber-reinforced composites, short-fiber materials, etc.), which enables higher-precision reconstruction of fiber-composites and significant reduction in dataset processing time, and provides a route to generating artificial learning dataset. [ABSTRACT FROM AUTHOR]