23 results on '"Liu, Jianquan"'
Search Results
2. The m6A modification mediated-lncRNA POU6F2-AS1 reprograms fatty acid metabolism and facilitates the growth of colorectal cancer via upregulation of FASN
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Jiang, Tao, Qi, Junwen, Xue, Zhenyu, Liu, Bowen, Liu, Jianquan, Hu, Qihang, Li, Yuqiu, Ren, Jing, Song, Hu, Xu, Yixin, Xu, Teng, Fan, Ruizhi, and Song, Jun
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- 2024
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3. Repeated turnovers keep sex chromosomes young in willows
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Wang, Deyan, Li, Yiling, Li, Mengmeng, Yang, Wenlu, Ma, Xinzhi, Zhang, Lei, Wang, Yubo, Feng, Yanlin, Zhang, Yuanyuan, Zhou, Ran, Sanderson, Brian J., Keefover-Ring, Ken, Yin, Tongming, Smart, Lawrence B., DiFazio, Stephen P., Liu, Jianquan, Olson, Matthew, and Ma, Tao
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- 2022
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4. PtoNF-YC9-SRMT-PtoRD26 module regulates the high saline tolerance of a triploid poplar
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Tong, Shaofei, Wang, Yubo, Chen, Ningning, Wang, Deyan, Liu, Bao, Wang, Weiwei, Chen, Yang, Liu, Jianquan, Ma, Tao, and Jiang, Yuanzhong
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- 2022
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5. A high-quality Buxus austro-yunnanensis (Buxales) genome provides new insights into karyotype evolution in early eudicots
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Wang, Zhenyue, Li, Ying, Sun, Pengchuan, Zhu, Mingjia, Wang, Dandan, Lu, Zhiqiang, Hu, Hongyin, Xu, Renping, Zhang, Jin, Ma, Jianxiang, Liu, Jianquan, and Yang, Yongzhi
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- 2022
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6. Single-cell RNA-seq data analysis characterizing bronchoalveolar epithelial cells in patients with SARS-CoV-2 infection
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Deng, Zhiqin, Li, Qin, Li, Yongshen, Deng, Zhenhan, Chen, Xiaoqiang, Zhao, Zhe, Wang, Guganghui, Wang, Daping, Liu, Jianquan, and Li, Wencui
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- 2022
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7. ANLN and UBE2T are prognostic biomarkers associated with immune regulation in breast cancer: a bioinformatics analysis
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Xiao, Yu, Deng, Zhiqin, Li, Yongshen, Wei, Baoting, Chen, Xiaoqiang, Zhao, Zhe, Xiu, Yingjie, Hu, Meifang, Alahdal, Murad, Deng, Zhenhan, Wang, Daping, Liu, Jianquan, and Li, Wencui
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- 2022
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8. Comparison of structural variants in the whole genome sequences of two Medicago truncatula ecotypes: Jemalong A17 and R108
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Li, Ao, Liu, Ai, Wu, Shuang, Qu, Kunjing, Hu, Hongyin, Yang, Jinli, Shrestha, Nawal, Liu, Jianquan, and Ren, Guangpeng
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- 2022
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9. The m6A modification mediated-lncRNA POU6F2-AS1 reprograms fatty acid metabolism and facilitates the growth of colorectal cancer via upregulation of FASN.
- Author
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Jiang, Tao, Qi, Junwen, Xue, Zhenyu, Liu, Bowen, Liu, Jianquan, Hu, Qihang, Li, Yuqiu, Ren, Jing, Song, Hu, Xu, Yixin, Xu, Teng, Fan, Ruizhi, and Song, Jun
- Subjects
LIQUID chromatography-mass spectrometry ,COLORECTAL cancer ,FATTY acids ,TUMOR growth ,STAINS & staining (Microscopy) - Abstract
Background: Long noncoding RNAs (lncRNAs) have emerged as key players in tumorigenesis and tumour progression. However, the biological functions and potential mechanisms of lncRNAs in colorectal cancer (CRC) are unclear. Methods: The novel lncRNA POU6F2-AS1 was identified through bioinformatics analysis, and its expression in CRC patients was verified via qRT–PCR and FISH. In vitro and in vivo experiments, such as BODIPY staining, Oil Red O staining, triglyceride (TAG) assays, and liquid chromatography mass spectrometry (LC-MS) were subsequently performed with CRC specimens and cells to determine the clinical significance, and functional roles of POU6F2-AS1. Biotinylated RNA pull-down, RIP, Me-RIP, ChIP, and patient-derived organoid (PDO) culture assays were performed to confirm the underlying mechanism of POU6F2-AS1. Results: The lncRNA POU6F2-AS1 is markedly upregulated in CRC and associated with adverse clinicopathological features and poor overall survival in CRC patients. Functionally, POU6F2-AS1 promotes the growth and lipogenesis of CRC cells both in vitro and in vivo. Mechanistically, METTL3-induced m
6 A modification is involved in the upregulation of POU6F2-AS1. Furthermore, upregulated POU6F2-AS1 could tether YBX1 to the FASN promoter to induce transcriptional activation, thus facilitating the growth and lipogenesis of CRC cells. Conclusions: Our data revealed that the upregulation of POU6F2-AS1 plays a critical role in CRC fatty acid metabolism and might provide a novel promising biomarker and therapeutic target for CRC. [ABSTRACT FROM AUTHOR]- Published
- 2024
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10. Transcriptional landscape of highly lignified poplar stems at single-cell resolution
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Chen, Yang, Tong, Shaofei, Jiang, Yuanzhong, Ai, Fandi, Feng, Yanlin, Zhang, Junlin, Gong, Jue, Qin, Jiajia, Zhang, Yuanyuan, Zhu, Yingying, Liu, Jianquan, and Ma, Tao
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- 2021
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11. Extensive genomic rearrangements mediated by repetitive sequences in plastomes of Medicago and its relatives
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Wu, Shuang, Chen, Jinyuan, Li, Ying, Liu, Ai, Li, Ao, Yin, Mou, Shrestha, Nawal, Liu, Jianquan, and Ren, Guangpeng
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- 2021
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12. Genome-wide (ChIP-seq) identification of target genes regulated by WRKY33 during submergence stress in Arabidopsis
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Zhang, Junlin, Liu, Bao, Song, Yan, Chen, Yang, Fu, Jiao, Liu, Jianquan, Ma, Tao, Xi, Zhenxiang, and Liu, Huanhuan
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- 2021
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13. A willow sex chromosome reveals convergent evolution of complex palindromic repeats
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Zhou, Ran, Macaya-Sanz, David, Carlson, Craig H., Schmutz, Jeremy, Jenkins, Jerry W., Kudrna, David, Sharma, Aditi, Sandor, Laura, Shu, Shengqiang, Barry, Kerrie, Tuskan, Gerald A., Ma, Tao, Liu, Jianquan, Olson, Matthew, Smart, Lawrence B., and DiFazio, Stephen P.
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- 2020
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14. Phylogeographic analysis of the fir species in southern China suggests complex origin and genetic admixture.
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Peng, Yanling, Yin, Shuming, Wang, Jing, Tian, Bin, Ren, Guangpeng, Guo, Qiuhong, and Liu, Jianquan
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FIR diseases & pests ,MITOCHONDRIAL DNA ,CHLOROPLAST DNA ,PHYLOGEOGRAPHY ,SPECIES hybridization ,PARSIMONIOUS models - Abstract
Context: Fir species are mainly distributed across the high latitudes, preferring cold climates. The phylogeographic origins of those subtropical fir species that occur in low latitudes in southern China remain elusive, as does the nature of any inter-lineage hybridization. Aims: In fir species, mitochondrial DNA (mtDNA) is maternally inherited and chloroplast DNA (cpDNA) is paternally inherited, and the genetic variations in the two make them particularly useful for examining species' hybridizations and evolutionary histories. Materials and methods: We sequenced four DNA fragments: two of mtDNA and two of cpDNA for 161 individuals from four subtropical endangered fir species ( Abies beshanzuensis, Abies ziyuanensis, Abies yuanbaoshanensis, and Abies fanjingshanensis) and two more northerly distributed ones ( Abies recurvata and Abies fargesii) from central and southwest China. Results: Three mitotypes and four chlorotypes were recovered from the four southern species. In most populations, individuals share a single fixed mitotype and chlorotype. Three mitotypes clustered into two distinct clades, each associated with one of the northern species examined. For four chlorotypes, one occurred in A. ziyuanensis, A. beshanzuensis, A. fargesii, and A. recurvata, another in A. ziyuanensis and A. recurvata, the remaining two differed from others by two mutations exclusively in A. fanjingshanenis and A. yuanbaoshanensis. Conclusion: Phylogeographic origins of the subtropical fir species are complex, and genetic admixtures occurred during the evolutionary history of A. ziyuanensis. The genotyped populations further provide basic frames for genetic delimitation and effective conservation of these endangered species in the future. [ABSTRACT FROM AUTHOR]
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- 2012
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15. The Yak genome database: an integrative database for studying yak biology and high-altitude adaption.
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Hu, Quanjun, Ma, Tao, Wang, Kun, Xu, Ting, Liu, Jianquan, and Qiu, Qiang
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YAK ,BIOLOGICAL adaptation ,MILK ,MEAT ,MOUNTAIN animals - Abstract
Background: The yak (Bos grunniens) is a long-haired bovine that lives at high altitudes and is an important source of milk, meat, fiber and fuel. The recent sequencing, assembly and annotation of its genome are expected to further our understanding of the means by which it has adapted to life at high altitudes and its ecologically important traits. Description: The Yak Genome Database (YGD) is an internet-based resource that provides access to genomic sequence data and predicted functional information concerning the genes and proteins of Bos grunniens. The curated data stored in the YGD includes genome sequences, predicted genes and associated annotations, non-coding RNA sequences, transposable elements, single nucleotide variants, and three-way whole-genome alignments between human, cattle and yak. YGD offers useful searching and data mining tools, including the ability to search for genes by name or using function keywords as well as GBrowse genome browsers and/or BLAST servers, which can be used to visualize genome regions and identify similar sequences. Sequence data from the YGD can also be downloaded to perform local searches. Conclusions: A new yak genome database (YGD) has been developed to facilitate studies on high-altitude adaption and bovine genomics. The database will be continuously updated to incorporate new information such as transcriptome data and population resequencing data. The YGD can be accessed at http://me.lzu.edu.cn/yak. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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16. Plastome phylogeny and early diversification of Brassicaceae.
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Guo X, Liu J, Hao G, Zhang L, Mao K, Wang X, Zhang D, Ma T, Hu Q, Al-Shehbaz IA, and Koch MA
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- Bayes Theorem, Brassicaceae classification, Genes, Plant genetics, Likelihood Functions, Sequence Alignment, Brassicaceae genetics, Chloroplasts genetics, Genome, Chloroplast genetics, Phylogeny
- Abstract
Background: The family Brassicaceae encompasses diverse species, many of which have high scientific and economic importance. Early diversifications and phylogenetic relationships between major lineages or clades remain unclear. Here we re-investigate Brassicaceae phylogeny with complete plastomes from 51 species representing all four lineages or 5 of 6 major clades (A, B, C, E and F) as identified in earlier studies., Results: Bayesian and maximum likelihood phylogenetic analyses using a partitioned supermatrix of 77 protein coding genes resulted in nearly identical tree topologies exemplified by highly supported relationships between clades. All four lineages were well identified and interrelationships between them were resolved. The previously defined Clade C was found to be paraphyletic (the genus Megadenia formed a separate lineage), while the remaining clades were monophyletic. Clade E (lineage III) was sister to clades B + C rather than to all core Brassicaceae (clades A + B + C or lineages I + II), as suggested by a previous transcriptome study. Molecular dating based on plastome phylogeny supported the origin of major lineages or clades between late Oligocene and early Miocene, and the following radiative diversification across the family took place within a short timescale. In addition, gene losses in the plastomes occurred multiple times during the evolutionary diversification of the family., Conclusions: Plastome phylogeny illustrates the early diversification of cruciferous species. This phylogeny will facilitate our further understanding of evolution and adaptation of numerous species in the model family Brassicaceae.
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- 2017
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17. The Year of the Wisent.
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Lenstra JA and Liu J
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- Animals, Caves, Bison genetics, Climate Change
- Abstract
Delving into European prehistory, two recent studies analyze ancient DNA from bison species depicted by our ancestors on the walls of their caves. The DNA tells a story of migrations driven by climate change but leaves some mystery clouding the genetic descent and climate preference of the still-extant wisent, otherwise known as the European bison.See research articles: https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-016-0317-7 http://www.nature.com/articles/ncomms13158.
- Published
- 2016
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18. Genetic origin and composition of a natural hybrid poplar Populus × jrtyschensis from two distantly related species.
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Jiang D, Feng J, Dong M, Wu G, Mao K, and Liu J
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- Cell Nucleus genetics, DNA, Chloroplast chemistry, DNA, Plant chemistry, DNA, Plant genetics, Ecosystem, Floods, Gene Flow, Genetics, Population, Geography, Haplotypes, Hybrid Vigor genetics, Hybridization, Genetic, Polymorphism, Genetic, Populus classification, Populus growth & development, Rivers, Sequence Analysis, DNA, Species Specificity, DNA, Chloroplast genetics, Genetic Variation, Microsatellite Repeats genetics, Populus genetics
- Abstract
Background: The factors that contribute to and maintain hybrid zones between distinct species are highly variable, depending on hybrid origins, frequencies and fitness. In this study, we aimed to examine genetic origins, compositions and possible maintenance of Populus × jrtyschensis, an assumed natural hybrid between two distantly related species. This hybrid poplar occurs mainly on the floodplains along the river valleys between the overlapping distributions of the two putative parents., Results: We collected 566 individuals from 45 typical populations of P. × jrtyschensis, P. nigra and P. laurifolia. We genotyped them based on the sequence variations of one maternally inherited chloroplast DNA (cpDNA) fragment and genetic polymorphisms at 20 SSR loci. We further sequenced eight nuclear genes for 168 individuals from 31 populations. Two groups of cpDNA haplotypes characteristic of P. nigra and P. laurifolia respectively were both recovered for P. × jrtyschensis. Genetic structures and coalescent tests of two sets of nuclear population genetic data suggested that P. × jrtyschensis originated from hybridizations between the two assumed parental species. All examined populations of P. × jrtyschensis comprise mainly F1 hybrids from interspecific hybridizations between P. nigra and P. laurifolia. In the habitats of P. × jrtyschensis, there are lower concentrations of soil nitrogen than in the habitats occupied by the other two species., Conclusions: Our extensive examination of the genetic composition of P. × jrtyschensis suggested that it is typical of F1-dominated hybrid zones. This finding plus the low concentration of soil nitrogen in the floodplain soils support the F1-dominated bounded hybrid superiority hypothesis of hybrid zone maintenance for this particular hybrid poplar.
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- 2016
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19. The salinity tolerant poplar database (STPD): a comprehensive database for studying tree salt-tolerant adaption and poplar genomics.
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Ma Y, Xu T, Wan D, Ma T, Shi S, Liu J, and Hu Q
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- Adaptation, Physiological drug effects, Genomics, Internet, Soil chemistry, User-Computer Interface, Databases, Genetic, Gene Expression Regulation, Plant drug effects, Genome, Plant, Populus genetics, Salts pharmacology
- Abstract
Background: Soil salinity is a significant factor that impairs plant growth and agricultural productivity, and numerous efforts are underway to enhance salt tolerance of economically important plants. Populus species are widely cultivated for diverse uses. Especially, they grow in different habitats, from salty soil to mesophytic environment, and are therefore used as a model genus for elucidating physiological and molecular mechanisms of stress tolerance in woody plants., Description: The Salinity Tolerant Poplar Database (STPD) is an integrative database for salt-tolerant poplar genome biology. Currently the STPD contains Populus euphratica genome and its related genetic resources. P. euphratica, with a preference of the salty habitats, has become a valuable genetic resource for the exploitation of tolerance characteristics in trees. This database contains curated data including genomic sequence, genes and gene functional information, non-coding RNA sequences, transposable elements, simple sequence repeats and single nucleotide polymorphisms information of P. euphratica, gene expression data between P. euphratica and Populus tomentosa, and whole-genome alignments between Populus trichocarpa, P. euphratica and Salix suchowensis. The STPD provides useful searching and data mining tools, including GBrowse genome browser, BLAST servers and genome alignments viewer, which can be used to browse genome regions, identify similar sequences and visualize genome alignments. Datasets within the STPD can also be downloaded to perform local searches., Conclusions: A new Salinity Tolerant Poplar Database has been developed to assist studies of salt tolerance in trees and poplar genomics. The database will be continuously updated to incorporate new genome-wide data of related poplar species. This database will serve as an infrastructure for researches on the molecular function of genes, comparative genomics, and evolution in closely related species as well as promote advances in molecular breeding within Populus. The STPD can be accessed at http://me.lzu.edu.cn/stpd/ .
- Published
- 2015
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20. Transcriptome differences between two sister desert poplar species under salt stress.
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Zhang J, Feng J, Lu J, Yang Y, Zhang X, Wan D, and Liu J
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- Alleles, Alternative Splicing, Genes, Plant, Polymerase Chain Reaction, Populus physiology, RNA, Messenger genetics, Species Specificity, Up-Regulation, Populus genetics, Sodium Chloride, Stress, Physiological, Transcriptome
- Abstract
Background: Populus euphratica Oliv and P. pruinosa Schrenk (Salicaceae) both grow in dry desert areas with high summer temperatures. However, P. euphratica is distributed in dry deserts with deep underground water whereas P. pruinosa occurs in deserts in which there is underground water close to the surface. We therefore hypothesized that these two sister species may have evolved divergent regulatory and metabolic pathways during their interaction with different salt habitats and other stresses. To test this hypothesis, we compared transcriptomes from callus exposed to 24 h of salt stress and control callus samples from both species and identified differentially expressed genes (DEGs) and alternative splicing (AS) events that had occurred under salt stress., Results: A total of 36,144 transcripts were identified and 1430 genes were found to be differentially expressed in at least one species in response to salt stress. Of these DEGs, 884 and 860 were identified in P. euphratica and P. pruinosa, respectively, while 314 DEGs were common to both species. On the basis of parametric analysis of gene set enrichment, GO enrichment in P. euphratica was found to be significantly different from that in P. pruinosa. Numerous genes involved in hormone biosynthesis, transporters and transcription factors showed clear differences between the two species in response to salt stress. We also identified 26,560 AS events which were mapped to 8380 poplar genomic loci from four libraries. GO enrichments for genes undergoing AS events in P. euphratica differed significantly from those in P. pruinosa., Conclusions: A number of salt-responsive genes in both P. euphratica and P. pruinosa were identified and candidate genes with potential roles in the salinity adaptation were proposed. Transcriptome comparisons of two sister desert poplar species under salt stress suggest that these two species may have developed different genetic pathways in order to adapt to different desert salt habitats. The DEGs that were found to be common to both species under salt stress may be especially important for future genetic improvement of cultivated poplars or other crops through transgenic approaches in order to increase tolerance of saline soil conditions.
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- 2014
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21. Transcriptome analyses of a Chinese hazelnut species Corylus mandshurica.
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Ma H, Lu Z, Liu B, Qiu Q, and Liu J
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- Corylus metabolism, Paclitaxel metabolism, Corylus genetics, Gene Expression Regulation, Plant, Transcriptome genetics
- Abstract
Background: Corylus was renowned for its production of hazelnut and taxol. To understand the local adaptation of Chinese species and speed up breeding efforts in China, we analyzed the leaf transcriptome of Corylus mandshurica, which had a high tolerance to fungal infections and cold., Results: A total of 12,255,030 clean pair-end reads were generated and then assembled into 37,846 Expressed Sequence Tag (EST) sequences. During functional annotation, 26,565 ESTs were annotated with Gene Ontology (GO) terms using Blast2go and 11,056 ESTs were grouped into the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways using KEGG Automatic Annotation Server (KAAS). We identified 45 ESTs that were homologous to enzymes and transcription factors responsible for taxol synthesis. The most differentiated orthologs between C. mandshurica and a European congener, C. avellana, were enriched in stress tolerance to fungal resistance and cold., Conclusions: In this study, we detected a set of genes related to taxol synthesis in a taxol-producing angiosperm species for the first time and found a close relationship between most differentiated genes and different adaptations to fungal infection and cold in C. mandshurica and C. avellana. These findings provided tools to improve our understanding of local adaptation, genetic breeding and taxol production in hazelnut.
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- 2013
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22. Phylogeography and allopatric divergence of cypress species (Cupressus L.) in the Qinghai-Tibetan Plateau and adjacent regions.
- Author
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Xu T, Abbott RJ, Milne RI, Mao K, Du FK, Wu G, Ciren Z, Miehe G, and Liu J
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- China, DNA, Chloroplast genetics, DNA, Plant genetics, Genetic Variation, Geography, Haplotypes, Sequence Analysis, DNA, Cupressus genetics, Evolution, Molecular, Genetics, Population, Phylogeny
- Abstract
Background: Although allopatric speciation is viewed as the most common way in which species originate, allopatric divergence among a group of closely related species has rarely been examined at the population level through phylogeographic analysis. Here we report such a case study on eight putative cypress (Cupressus) species, which each have a mainly allopatric distribution in the Qinghai-Tibetan Plateau (QTP) and adjacent regions. The analysis involved sequencing three plastid DNA fragments (trnD-trnT, trnS-trnG and trnL-trnF) in 371 individuals sampled from populations at 66 localities., Results: Both phylogenetic and network analyses showed that most DNA haplotypes recovered or haplotype-clustered lineages resolved were largely species-specific. Across all species, significant phylogeographic structure (N(ST) > G(ST), P < 0.05) implied a high correlation between haplotypes/lineages and geographic distribution. Two species, C. duclouxiana and C. chengiana, which are distributed in the eastern QTP region, contained more haplotypes and higher diversity than five species with restricted distributions in the western highlands of the QTP. The remaining species, C. funebris, is widely cultivated and contained very little cpDNA diversity., Conclusions: It is concluded that the formation of high mountain barriers separating deep valleys in the QTP and adjacent regions caused by various uplifts of the plateau since the early Miocene most likely promoted allopatric divergence in Cupressus by restricting gene flow and fixing local, species-specific haplotypes in geographically isolated populations. The low levels of intraspecific diversity present in most species might stem from population bottlenecks brought about by recurrent periods of unfavorable climate and more recently by the negative impacts of human activities on species' distributions. Our findings shed new light on the importance of geographical isolation caused by the uplift of the QTP on the development of high plant species diversity in the QTP biodiversity hotspot.
- Published
- 2010
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23. Origin of mitochondrial DNA diversity of domestic yaks.
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Guo S, Savolainen P, Su J, Zhang Q, Qi D, Zhou J, Zhong Y, Zhao X, and Liu J
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- Animals, Animals, Wild genetics, Molecular Sequence Data, Phylogeny, Animals, Domestic genetics, Cattle genetics, DNA, Mitochondrial genetics, Evolution, Molecular, Genetic Variation genetics
- Abstract
Background: The domestication of plants and animals was extremely important anthropologically. Previous studies have revealed a general tendency for populations of livestock species to include deeply divergent maternal lineages, indicating that they were domesticated in multiple, independent events from genetically discrete wild populations. However, in water buffalo, there are suggestions that a similar deep maternal bifurcation may have originated from a single population. These hypotheses have rarely been rigorously tested because of a lack of sufficient wild samples. To investigate the origin of the domestic yak (Poephagus grunnies), we analyzed 637 bp of maternal inherited mtDNA from 13 wild yaks (including eight wild yaks from a small population in west Qinghai) and 250 domesticated yaks from major herding regions., Results: The domestic yak populations had two deeply divergent phylogenetic groups with a divergence time of > 100,000 yrs BP. We here show that haplotypes clustering with two deeply divergent maternal lineages in domesticated yaks occur in a single, small, wild population. This finding suggests that all domestic yaks are derived from a single wild gene pool. However, there is no clear correlation of the mtDNA phylogenetic clades and the 10 morphological types of sampled yaks indicating that the latter diversified recently. Relatively high diversity was found in Qinghai and Tibet around the current wild distribution, in accordance with previous suggestions that the earliest domestications occurred in this region. Conventional molecular clock estimation led to an unrealistic early dating of the start of the domestication. However, Bayesian estimation of the coalescence time allowing a relaxation of the mutation rate are better in agreement with a domestication during the Holocene as supported by archeological records., Conclusion: The information gathered here and the previous studies of other animals show that the demographic histories of domestication of livestock species were highly diverse despite the common general feature of deeply divergent maternal lineages. The results further suggest that domestication of local wild prey ungulate animals was a common occurrence during the development of human civilization following the postglacial colonization in different locations of the world, including the high, arid Qinghai-Tibetan Plateau.
- Published
- 2006
- Full Text
- View/download PDF
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