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Climate change caused by land use/cover change (LUCC) is becoming a hot topic in current global change, especially the changes caused by the grassland degradation. In this paper, based on the baseline underlying surface data of 1993, the predicted underlying surface data which can be derived through overlaying the grassland degradation information to the map of baseline underlying surface, and the atmospheric forcing data of RCP 6.0 from CMIP5, climatological changes caused by future grassland changes for the years 2010-2020 and 2040-2050 with the Weather Research Forecast model (WRF) are simulated. The model-based analysis shows that future grassland degradation will significantly result in regional climate change. The grassland degradation in future could lead to an increasing trend of temperature in most areas and corresponding change range of the annual average temperature of -0.1°C- 0.4°C, and it will cause a decreasing trend of precipitation and corresponding change range of the annual average precipitation of 10 mm-50 mm. This study identifies lines of evidence for effects of future grassland degradation on regional climate in Mongolia which provides meaningful decision-making information for the development and strategy plan making in Mongolia. [ABSTRACT FROM AUTHOR]