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Enfuvirtide (ENF) is a peptide medicine clinically used for the treatment of HIV infections. The outcome shows that mesoporous HSNs having pores that are thought to be larger than ENF are better substances for the ingression of ENF with MW = 4492.1 g/mol than microporous HSNs. HPSNs that can internally keep peptide medicine like ENF can provide the peptide with good protection from external protease digestion, which are generally considered as 10 times bigger than peptides, reduce the biodegradability of the medicine, and maintain the remedial effect longer. They are not so different from that of ENF lane in which ENF amount is 10 g. Therefore, ENF was consistently released from HPSN every about 8-10% after 14, 19, and 33 days. [Extracted from the article]