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Your search keyword '"Wang, Rong-Yue"' showing total 7 results
Start Over Author "Wang, Rong-Yue" Language english Publication Type Academic Journals
7 results on '"Wang, Rong-Yue"'

5. Detection of Parental Contribution to Molar Genome Leads to Diagnosis of Recurrent Hydatidiform Mole in a Family with NLRP7 Variants.

Author

Wang, Rong-Yue, Li, Yu-Juan, Zhen, Li, Jiang, Fan, Gu, Cong-Min, and Li, Dong-Zhi

Subjects
*MOLAR pregnancy, *GENETIC testing, *GENETIC variation, *GENETIC counseling, *GENOMES, *DIAGNOSIS, *POLYPLOIDY
Abstract

Introduction: Genetically, complete hydatidiform mole (CHM) is androgenetic diploid, containing two sets of paternal chromosomes. In most cases, recurrent HM (RHM) is CHM but has diploid biparental chromosome constitution. Case report: We report a mother with RHM, both with biparental diploidy. The mother was compound heterozygous for two variants, c.1720dup, p.(C574Lfs*4) and c.2165A > G, p.(D722G) of the NLRP7 gene, as was a brother who fathered 2 normal pregnancies. Conclusion: The genotype study should be obtained for patients of CHM, even in their first pregnancy, followed by genetic screening for maternal-effect variants in those with biparental moles. This strategy will identify patients in their first pregnancy with HM that have a decreased chance for a normal pregnancy, to allow genetic counseling, perhaps utilizing a donor egg. [ABSTRACT FROM AUTHOR]

Published
2022
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6. Mild α-Thalassemia Caused by a Mosaic α-Globin Gene Mutation.

Author

Wang, Rong-Yue, Jiang, Fan, Xu, Li-Li, and Li, Dong-Zhi

Subjects
*GENETIC mutation, *PHENOTYPES, *MOSAICISM
Abstract

We describe a new α-globin chain variant in a Chinese subject. This novel variant, with a Val→Met substitution at codon 93 of the α-globin chain, has been named Hb Qingcheng (HBA1: c.280G>A) for where the proband was born. A woman with somatic mosaicism for Hb Qingcheng presented with the phenotype of mild α-thalassemia (α-thal). [ABSTRACT FROM AUTHOR]

Published
2021
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7. Healthy neonate born to a SARS-CoV-2 infected woman: A case report and review of literature.

Author

Wang RY, Zheng KQ, Xu BZ, Zhang W, Si JG, Xu CY, Chen H, Xu ZY, and Wu XM

Abstract

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered coronavirus that has generated a worldwide outbreak of infections. Many people with coronavirus disease-2019 (COVID-19) have developed severe illness, and a significant number have died. However, little is known regarding infection by the novel virus in pregnant women. We herein present a case of COVID-19 confirmed in a woman delivering a neonate who was negative for SARS-CoV-2 and related it to a review of the literature on pregnant women and human coronavirus infections., Case Summary: The patient was a 36-year-old pregnant woman in her third trimester who had developed progressive clinical symptoms when she was confirmed as infected with SARS-CoV-2. Given the potential risks for both the pregnant woman and the fetus, an emergency cesarean section was performed, and the baby and his mother were separately quarantined and cared for. As a result, the baby currently shows no signs of SARS-CoV-2 infection (his lower respiratory tract samples were negative for the virus), while the mother completely recovered from COVID-19., Conclusion: Although we presented a single case, the successful result is of great significance for pregnant women with SARS-CoV-2 infection and with respect to fully understanding novel coronavirus pneumonia., Competing Interests: Conflict-of-interest statement: The authors report no conflicts of interest., (©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.)

Published
2020
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