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Your search keyword '"Guo, Chang"' showing total 2,697 results
Start Over Author "Guo, Chang" Language english Publication Type Book Reviews
2,697 results on '"Guo, Chang"'

11. Stepped-up development of accelerator mass spectrometry method for the detection of 60Fe with the HI-13 tandem accelerator

Author

Zhang, Yang, Yan, Sheng-Quan, He, Ming, Zhao, Qing-Zhang, Zhang, Wen-Hui, Kan, Chao-Xin, Zhou, Jian-Ming, Li, Kang-Ning, Wang, Xiao-Fei, Liu, Jian-Cheng, Peng, Zhao-Hua, Liang, Zhuo, Li, Ai-Ling, Zheng, Jian, Fan, Qi-Wen, Li, Yun-Ju, Wang, You-Bao, Li, Zhi-Hong, Shen, Yang-Ping, Nan, Ding, Nan, Wei, Zhang, Yu-Qiang, Li, Jia-Ying-Hao, Tian, Jun-Wen, Hou, Jiang-Lin, Guo, Chang-Xin, Zhang, Zhi-Cheng, Zhu, Ming-Hao, Chen, Yu-Wen, Jiang, Yu-Chen, Tian, Tao, Ma, Jin-Long, Liu, Yi-Hui, Dong, Jing-Yu, Liu, Run-Long, Ma, Mei-Yue-Nan, Chen, Yong-Shou, Liu, Wei-Ping, and Guo, Bing

Published
2024
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14. Nicotinamide mononucleotide as a therapeutic agent to alleviate multi-organ failure in sepsis

Author

Ting Cao, Rui Ni, Weimin Ding, Xiaoyun Ji, Guo-Chang Fan, Zhuxu Zhang, and Tianqing Peng

Subjects
Medicine
Abstract

Abstract Background Sepsis-caused multi-organ failure remains the major cause of morbidity and mortality in intensive care units with limited therapeutics. Nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD+), has been recently reported to be protective in sepsis; however, its therapeutic effects remain to be determined. This study sought to investigate the therapeutic effects of NMN in septic organ failure and its underlying mechanisms. Methods Sepsis was induced by feces-injection-in-peritoneum in mice. NMN was given after an hour of sepsis onset. Cultured neutrophils, macrophages and endothelial cells were incubated with various agents. Results We demonstrate that administration of NMN elevated NAD+ levels and reduced serum lactate levels, oxidative stress, inflammation, and caspase-3 activity in multiple organs of septic mice, which correlated with the attenuation of heart dysfunction, pulmonary microvascular permeability, liver injury, and kidney dysfunction, leading to lower mortality. The therapeutic effects of NMN were associated with lower bacterial burden in blood, and less ROS production in septic mice. NMN improved bacterial phagocytosis and bactericidal activity of macrophages and neutrophils while reducing the lipopolysaccharides-induced inflammatory response of macrophages. In cultured endothelial cells, NMN mitigated mitochondrial dysfunction, inflammation, apoptosis, and barrier dysfunction induced by septic conditions, all of which were offset by SIRT3 inhibition. Conclusion NAD+ repletion with NMN prevents mitochondrial dysfunction and restrains bacterial dissemination while limiting inflammatory damage through SIRT3 signaling in sepsis. Thus, NMN may represent a therapeutic option for sepsis.

Published
2023
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15. Enriched lithospheric mantle storage of the Earth's missing niobium: New insights from alkaline rocks with superchondritic Nb/Ta ratios

Author

Yan Yang, Franz Neubauer, Zheng Liu, Guo-Chang Wang, Shu-Cheng Tan, Xiao-Hu He, and Chen-Yue Liang

Subjects
Superchondritic Nb/Ta ratios, Alkaline rocks, Lithospheric mantle, Subducted sediment, Earth's niobium, Physical geography, GB3-5030
Abstract

Accessible silicate reservoirs on Earth (i.e., the depleted mantle and continental crust) are depleted in Nb relative to chondrites, as expressed by their subchondritic Nb/Ta ratios. Mixtures of continental crust and depleted mantle cannot produce chondritic Nb/Ta ratios; therefore, another geochemical reservoir with a superchondritic Nb/Ta ratio is necessary to balance the low Nb contents of the continental crust. We investigated alkaline igneous rocks with superchondritic Nb/Ta ratios (20.4–24.8). Their high Nb/Ta ratios were inherited from their lithospheric mantle source rather than being produced by magmatic differentiation. Geochemical data show that an enriched mantle domain with superchondritic Nb/Ta ratios can be produced by the interaction of subducted carbonate-rich sediment-derived melts with the lithospheric mantle, and the enriched lithospheric mantle is a potential superchondritic reservoir.

Published
2024
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35. An Insulin-Modified pH-Responsive Nanopipette Based on Ion Current Rectification

Author

Xu-Fan Wang, Yi-Fan Duan, Yue-Qian Zhu, Zi-Jing Liu, Yu-Chen Wu, Tian-Hao Liu, Ling Zhang, Jian-Feng Wei, and Guo-Chang Liu

Subjects
nanopipettes, bovine insulin, ion current rectification, silanization and amidation, pH response, Chemical technology, TP1-1185
Abstract

The properties of nanopipettes largely rely on the materials introduced onto their inner walls, which allow for a vast extension of their sensing capabilities. The challenge of simultaneously enhancing the sensitivity and selectivity of nanopipettes for pH sensing remains, hindering their practical applications. Herein, we report insulin-modified nanopipettes with excellent pH response performances, which were prepared by introducing insulin onto their inner walls via a two-step reaction involving silanization and amidation. The pH response intensity based on ion current rectification was significantly enhanced by approximately 4.29 times when utilizing insulin-modified nanopipettes compared with bare ones, demonstrating a linear response within the pH range of 2.50 to 7.80. In addition, insulin-modified nanopipettes featured good reversibility and selectivity. The modification processes were monitored using the I-V curves, and the relevant mechanisms were discussed. The effects of solution pH and insulin concentration on the modification results were investigated to achieve optimal insulin introduction. This study showed that the pH response behavior of nanopipettes can be greatly improved by introducing versatile molecules onto the inner walls, thereby contributing to the development and utilization of pH-responsive nanopipettes.

Published
2024
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