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The electroreduction of CO2 to methane using renewable energy is a promising approach to achieving carbon neutrality. At commercially relevant current densities (>200 mA cm−2), methane selectivity is however below 50%. Herein, we reported a benzenethiol-modified Cu nanoparticle catalyst that achieved a methane faradaic efficiency of 54.5% at a partial current density of 383 mA cm−2, 1.9-fold higher than that of Cu nanoparticle controls. In situ vibrational spectroscopy and density functional theory calculations showed that the benzenethiol modulated the electronic structure of the Cu surface to enable a lowered coverage of *CO, favouring the formation of *CHO, a key intermediate embarking on the CH4 pathway, over the competing carbon–carbon coupling, the pathway towards multicarbons. [ABSTRACT FROM AUTHOR]

We developed a biodegradable, oncosensitive, megamer-based delivery system for miRNA therapy. The miRNA nanotherapeutics, activatable by stepwise stimulation of acidity and reduction mimicking tumor microenvironment, efficiently improve liver-specific miR-122 expression, increasing the possibility of translational application of miR-122 therapy against liver cancer. [ABSTRACT FROM AUTHOR]