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This paper outlines the response of the healthcare system in the area mainly affected by the 2012 Emilia earthquake by drawing on specific surveys and information from local health authorities. Some hospitals were evacuated after the M $$_\mathrm{l}$$ = 5.8 May 20 seismic event due to damage to non structural components and minor structural damage. A short description of the damage suffered and characteristics of the healthcare system as a whole is offered initially, followed by a detailed description of the effects which took place at the Santa Maria Bianca hospital of Mirandola. The focus has been on damage to non structural elements and content, whose integrity is of primary importance for healthcare structures performance during and after a seismic event. Some instruments for the acquisition of accelerometric data were installed after the May 20 event both outside and inside a building which is part of the hospital complex. The seismic behavior of this building has also been analysed by means of a purposely made finite element model and on the basis of the recorded data. The contribution of undamaged and damaged masonry infills to the global seismic response has also been estimated thus providing some hints on the observed building performance. [ABSTRACT FROM AUTHOR]