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Background: Sleeve gastrectomy with transit bipartition (SG-TB) procedure has been gaining traction recently. While being a relatively novel procedure, it shows potentials to improve the standalone SG outcomes, such as diabetes remission and reflux. This article aims to show insights on performing SG-TB in one anastomosis fashion (SG-OATB) and single-port approach. Methods: Three patients who underwent laparoscopic single-port SG-OATB at our hospital were included. The parameters included in this study comprised of age, gender, height, weight, body mass index (BMI), type 2 diabetes mellitus (T2DM) assessment, gastroesophageal reflux disease (GERD) assessment, length of the small bowel, the duration of the procedure, and 30-day readmission rate. Results: The mean preoperative assessments for the three patients were as follows: two females vs. one male; age 38.7 ± 5.5 years old; weight 105.7 ± 5.4 kg; height 1.64 ± 0.11 m; BMI 39.3 ± 4.7 kg/m2; fasting blood glucose 6.7 ± 1.2 mmol/L; glycosylated hemoglobin level 7.1 ± 1.3%; GERD-Questionnaire score 6.3 ± 1.5; two patients with esophagitis grade A and B following endoscopy. The total duration of the procedure was 170.0 ± 26.5 min; there was no need for conversion to multiple-port in all patients. The 30-day readmission rate for all patients was 0%. Conclusion: In our small cases of patients, single-port SG-OATB is feasible and safe. We found the closure of the anastomosis defect to be most technically demanding. To understand better the outcome of single-port SG-OATB, studies with larger sample and longer follow-up will be needed in the future. [ABSTRACT FROM AUTHOR]

Background: Due to limited technical demand, single-port sleeve gastrectomy (SPSG) is a feasible laparoscopic technique for sleeve gastrectomy (SG). Nonetheless, difficulties exist when performing the single-port technique, and in this study, we aim to describe a slight maneuver that can improve the SPSG procedure. Methods: Patients who underwent laparoscopic SG between January 2022 and May 2023 at our hospital were included. The patients were classified into two groups: (1) SPSG and (2) multiple-port SG (MPSG). The parameters for this analysis were the patients' age, gender, weight, body mass index (BMI), conversion rate, drainage placement, 30-day readmission rate, and postoperative complications. Postoperative one-month and three-month percentages of total weight loss (%TWL) were calculated and compared. Results: 171 patients were included in this study: (1) the SPSG group (n = 96) and (2) the MPSG group (n = 75). No statistically significant difference was observed within the preoperative (age, gender, height, weight, and BMI) and the perioperative parameters between SPSG and MPSG (operation time, drainage placement, 30-day readmission) (p > 0.05). Per Clavien–Dindo's grading, two patients in the SPSG group suffered grade 1 complications; for the MPSG group, one patient sustained grade 2 and another suffered grade 3b complication. No statistical significance was observed on the %TWL between the two groups (p > 0.05). Conclusion: Our study found that performing SPSG in specific patient is feasible and non-inferior when compared to the MPSG. Further studies will be needed to elucidate better the efficacy and safety of performing SPSG. [ABSTRACT FROM AUTHOR]

Aim: To compare the efficacy and safety of synthetic and biological meshes in ventral hernia repair (VHR) and abdominal wall reconstruction (AWR). Methods: We screened all clinical trials that reported the application of synthetic and biological meshes in VHR and AWR using Medline, Web of Science, and Embase (Ovid). Only comparative studies with similar baselines such as age, sex, body mass index, degree of wound contamination, and hernia defects between the intervention and control groups were included. Effect sizes with 95% confidence were pooled using a random- or fixed-effects model based on the size of heterogeneity. A sensitivity analysis was performed to test the stability of the results. Results: Ten studies with 1305 participants were included. Biological meshes were associated with significantly higher recurrence rate (OR, 2.09; 95% CI 1.42–3.08; I2 = 50%), surgical site infection (OR, 1.47; 95% CI 1.10–1.97; I2 = 30%), higher re-admission rate (OR, 1.51; 95% CI 1.05–2.17; I2 = 50%), and longer length of hospital stay (SMD, 0.37; 95% CI 0.10–0.65; I2 = 72%). Similar surgical site occurrence, re-operation rate, and mesh explantation rate were observed among biological and synthetic meshes. Biological meshes have no difference in recurrence rate as compared to synthetic meshes, between the clean-contaminated, and contamination-infected fields (OR, 1.41; 95% CI 0.41–4.87 vs 3.00; 95% CI 1.07–8.46; P = 0.36). Conclusion: Synthetic meshes are a safe alternative to biological meshes for VHR and AWR. Considering the high cost of biological meshes, synthetic meshes are more appropriate for the VHR and AWR. [ABSTRACT FROM AUTHOR]

Intelligent magnetic materials are capable of responding to environmental stimuli in an on/off manner. The photo- and thermal-responsive nanogel layer was surface-grafted onto several magnetic nanoparticles to prepare the magnetic imprinted nanoparticles (Fe3O4 MIPs). The Fe3O4 MIPs show dramatic temperature and light, dual-dependent rebinding and release characteristics for lysozyme. Above the volume phase transition temperature of the PNIPAAm, the imprinted protein (lysozyme) can be selectively separated from egg whites and the activity remained unchanged. By combining low temperature and UV irradiation, a more finely tuned release of the binding protein can be achieved. Time-dependent antibacterial activity was observed, and it was found that Fe3O4 MIPs-loaded lysozyme almost completely suppressed the growth of E. coli with the continuous lysozyme release. More importantly, the Fe3O4 MIPs could easily be separated by an external magnetic field and can be recycled. The photo- and thermal-responsive Fe3O4 MIPs pave a new way for the development of an advanced, sustainable material for use in bioseparation, drug delivery, and antibacterial materials. [ABSTRACT FROM AUTHOR]

The multifunctional hemin@carbon dot hybrid nanozymes (hemin@CD) with simultaneous peroxidase-like activity and fluorescence signalling property was prepared for the first time. Based on these properties, hemin@CD was applied to develop a dual-channel fluorescent probe for H2O2 and H2O2-based biocatalytic systems. By virtue of the peroxidase-like activity, hemin@CD can catalyze the oxidative coupling of 4-aminoantipyrine with phenol in the presence of H2O2 to form a pink-red quinoneimine dye with a maximum absorbance at 505 nm. Under the excitation wavelength of 480 nm, the green fluorescence of hemin@CD peaks at 540 nm and is quenched by the generated quinoneimine dye due to an inner filter effect, and also by H2O2 because of dynamic quenching. Thus, a colorimetric and fluorimetric dual-channel optical probe for H2O2 is obtained. Due to the glucose/xanthine transformations under formation of H2O2 by the relevant oxidase catalysis, the probe can be applied for detection of glucose and xanthine. The colorimetric detection limits for H2O2, glucose and xanthine are 0.11, 0.15, 0.11 μM, and the and fluorimetric detection limits are 0.15, 0.15, 0.12 μM, respectively. [ABSTRACT FROM AUTHOR]

Camptothecin (CPT) is a potent and broad-spectrum anti-tumor drug, but its clinical application is limited due to its poor water solubility, toxicity, and low drug-loading potential. Different delivery protocols have been developed to optimize the therapeutic effects of CPT. In this study, CPT was modified into a dimer (CPT-Mal-CPT), in which two CPT molecules are connected by a reduction-responsive maleimide thioether bond. Moreover, biocompatible methoxy poly(ethylene glycol)-b-poly(ε-caprolactone) (mPEG–PCL)-loaded CPT-Mal-CPT nanoparticles were prepared to overcome the limits of CPT application. The power X-ray diffractometer (PXRD) results indicate low crystallinity and amorphous nature of CPT-Mal-CPT. The CPT-Mal-CPT-loaded micelles showed a drug-loading content of 9.6% and a drug-loading efficiency of 56%. In addition, dimeric CPT micelles showed reduction-responsive release under 10-mM dithiothreitol (DTT), while negligible CPT release was detected in the absence of DTT. MTT assay indicated that cytotoxicity of dimeric CPT micelle was similar to free CPT. [ABSTRACT FROM AUTHOR]

In engineering practice, deep learning is commonly used for small-sample fault diagnosis of mechanical equipment under heavy noise interference. In recent years, many researchers have used attentional neural operators based on CNNs to extract feature representations from complex data. However, the current attentional neural operator-based fault diagnosis method still has the following limitations: (1) CNN performs poorly in global feature extraction and is unable to capture the global dependencies of long sequential signals. (2) Neural operators have a serious information loss problem in multi-level feature computation, which is unfavorable for processing sensor signals that are long and contain complex noise. To address these problems, we innovatively design an efficient attentional neural operator, and also propose a new lightweight model called CSDANet. Firstly, the spatial interaction between local and global in vibration signals is facilitated by introducing a multi-level convolution and layer scaling strategies; secondly, We designed a feature channel with long-term memory capacity to cope with the adverse effects of information loss on the model; Finally, a vibration signal feature extractor is proposed to obtain richer feature mapping from the original one-dimensional sensor signals, which significantly improves the ability of the attention module to perceive multi-frequency domain noise features while consuming less computational resources. The results of two experiments demonstrate that the proposed approach accommodates advantages of lightweight and robustness in small-sample fault diagnosis tasks, compared to the existing mainstream Transformer and CNN fault diagnosis frameworks. [ABSTRACT FROM AUTHOR]