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Brain tumors are one of the most deadly diseases with a high mortality rate. The shape and size of the tumor are random during the growth process. Brain tumor segmentation is a brain tumor assisted diagnosis technology that separates different brain tumor structures such as edema and active and tumor necrosis tissues from normal brain tissue. Magnetic resonance imaging (MRI) technology has the advantages of no radiation impact on the human body, good imaging effect on structural tissues, and an ability to realize tomographic imaging of any orientation. Therefore, doctors often use MRI brain tumor images to analyze and process brain tumors. In these images, the tumor structure is only characterized by grayscale changes, and the developed images obtained by different equipment and different conditions may also be different. This makes it difficult for traditional image segmentation methods to deal well with the segmentation of brain tumor images. Considering that the traditional single-mode MRI brain tumor images contain incomplete brain tumor information, it is difficult to segment the single-mode brain tumor images to meet clinical needs. In this paper, a sparse subspace clustering (SSC) algorithm is introduced to process the diagnosis of multimodal MRI brain tumor images. In the absence of added noise, the proposed algorithm has better advantages than traditional methods. Compared with the top 15 in the Brats 2015 competition, the accuracy is not much different, being basically stable between 10 and 15. In order to verify the noise resistance of the proposed algorithm, this paper adds 5%, 10%, 15%, and 20% Gaussian noise to the test image. Experimental results show that the proposed algorithm has better noise immunity than a comparable algorithm.

Automatic liver and tumour segmentation in CT images are crucial in numerous clinical applications, such as postoperative assessment, surgical planning, and pathological diagnosis of hepatic diseases. However, there are still a considerable number of difficulties to overcome due to the fuzzy boundary, irregular shapes, and complex tissues of the liver. In this paper, for liver and tumor segmentation and to overcome the mentioned challenges a simple but powerful strategy is presented based on a cascade convolutional neural network. At the first, the input image is normalized using the Z-Score algorithm. This normalized image provides more information about the boundary of tumor and liver. Also, the Local Direction of Gradient (LDOG) which is a novel encoding algorithm is proposed to demonstrate some key features inside the image. The proposed encoding image is highly effective in recognizing the border of liver, even in the regions close to the touching organs. Then, a cascade CNN structure for extracting both local and semi-global features is used which utilized the original image and two other obtained images as the input data. Rather than using a complex deep CNN model with a lot of hyperparameters, we employ a simple but effective model to decrease the train and testing time. Our technique outperforms the state-of-the-art works in terms of segmentation accuracy and efficiency.

Pupil segmentation is critical for line-of-sight estimation based on the pupil center method. Due to noise and individual differences in human eyes, the quality of eye images often varies, making pupil segmentation difficult. In this paper, we propose a pupil segmentation method based on fuzzy clustering of distributed information, which first preprocesses the original eye image to remove features such as eyebrows and shadows and highlight the pupil area, then the Gaussian model is introduced into global distribution information to enhance the classification fuzzy affiliation for the local neighborhood, and an adaptive local window filter that fuses local spatial and intensity information is proposed to suppress the noise in the image and preserve the edge information of the pupil details. Finally, the intensity histogram of the filtered image is used for fast clustering to obtain the clustering center of the pupil, and this binarization process is used to segment the pupil for the next pupil localization. Experimental results show that the method has high segmentation accuracy, sensitivity, and specificity. It can accurately segment the pupil when there are interference factors such as light spots, light reflection, and contrast difference at the edge of the pupil, which is an important contribution to improving the stability and accuracy of the line-of-sight tracking.

Early diagnosis of tumor plays an important role in the improvement of treatment and survival rate of patients. However, breast tumors are difficult to be diagnosed by invasive examination, so medical imaging has become the most intuitive auxiliary method for breast tumor diagnosis. Although there is no universal perfect method for image segmentation so far, the consensus on the general law of image segmentation has produced considerable research results and methods. In this context, this paper focuses on the breast tumor image segmentation method based on CNN and proposes an improved DCNN method combined with CRF. This method can obtain the information of multiscale and pixels better. The experimental results show that, compared with DCNN without these methods, the segmentation accuracy is significantly improved.

This paper aimed to discuss the denoising ability of magnetic resonance imaging (MRI) images based on fuzzy C-means clustering (FCM) algorithm and the influence of Butylphthalide combined with Edaravone treatment on nerve function and vascular endothelial function in patients with acute cerebral infarction (ACI). Based on FCM algorithm, Markov Random Field (MRF) model algorithm was introduced to obtain a novel algorithm (NFCM), which was compared with FCM and MRF algorithm in terms of misclassification rate (MCR) and difference of Kappa index (KI). 90 patients with ACI diagnosed in hospital from December 2018 to December 2019 were selected as subjects, who were divided into combined treatment group (conventional treatment + Edaravone + Butylphthalide) and Edaravone group (conventional treatment + Edaravone) randomly, each consisting of 45 cases. The National Institutes of Health Stroke Scale (NIHSS) score and endothelial function index level such as plasma nitric oxide (NO), human endothelin-1 (ET-1), and vascular endothelial cell growth factor (VEGF) were compared before and after treatment between the two groups. The results showed that the MCR of NFCM was evidently inferior to FCM and MRF, and the KI was notably higher relative to the other two algorithms. After treatment, the NIHSS score of the combined treatment group was (9.09 ± 1.86) points and that of Edaravone group was (14.97 ± 3.44) points, with evident difference between the two groups ( P < 0.05 ). After treatment, the NO of the combined treatment was (54.63 ± 4.85), and that of Edaravone group was (41.54 ± 5.27), which was considerably different ( P < 0.01 ), and the VEGF and ET-1 of combined treatment group were greatly inferior to Edaravone group ( P < 0.01 ). It was revealed that the novel algorithm based on FCM can obtain more favorable quality and segmentation accuracy of MRI images. Moreover, Butylphthalide combined with Edaravone treatment can effectively improve nerve function, vascular endothelial function, and short-term prognosis in ACI, which was safe and worthy of clinical adoption.

In this paper, we present a new multi-objective optimization approach for segmentation of Magnetic Resonance Imaging (MRI) of the human brain. The proposed algorithm not only takes advantages but also solves major drawbacks of two well-known complementary techniques, called fuzzy entropy clustering method and region-based active contour method, using multi-objective particle swarm optimization (MOPSO) approach. In order to obtain accurate segmentation results, firstly, two fitness functions with independent characteristics, compactness and separation, are derived from kernelized fuzzy entropy clustering with local spatial information and bias correction (KFECSB) and a novel adaptive energy weight combined with global and local fitting energy active contour (AWGLAC) model. Then, they are simultaneously optimized to finally produce a set of non-dominated solutions, from which L2-metric method is used to select the best trade-off solution. Our algorithm is both verified and compared with other state-of-the-art methods using simulated MR images and real MR images from the McConnell Brain Imaging Center (BrainWeb) and the Internet Brain Segmentation Repository (IBSR), respectively. The experimental results demonstrate that the proposed technique achieves superior segmentation performance in terms of accuracy and robustness.

Automatic segmentation of particular heart parts plays an important role in recognition tasks, which is utilized for diagnosis and treatment. One particularly important application is segmentation of epicardial fat (surrounds the heart), which is shown by various studies to indicate risk level for developing various cardiovascular diseases as well as to predict progression of certain diseases. Quantification of epicardial fat from CT images requires advance image segmentation methods. The problem of the state-of-the-art methods for epicardial fat segmentation is their high dependency on user interaction, resulting in low reproducibility of studies and time-consuming analysis. We propose in this paper a novel semiautomatic approach for segmentation and quantification of epicardial fat from 3D CT images. Our method is a semisupervised slice-by-slice segmentation approach based on local adaptive morphology and fuzzy c-means clustering. Additionally, we use a geometric ellipse prior to filter out undesired parts of the target cluster. The validation of the proposed methodology shows good correspondence between the segmentation results and the manual segmentation performed by physicians.

Image segmentation plays an important role in medical image processing. Fuzzyc-means (FCM) clustering is one of the popular clustering algorithms for medical image segmentation. However, FCM has the problems of depending on initial clustering centers, falling into local optimal solution easily, and sensitivity to noise disturbance. To solve these problems, this paper proposes a hybrid artificial fish swarm algorithm (HAFSA). The proposed algorithm combines artificial fish swarm algorithm (AFSA) with FCM whose advantages of global optimization searching and parallel computing ability of AFSA are utilized to find a superior result. Meanwhile, Metropolis criterion and noise reduction mechanism are introduced to AFSA for enhancing the convergence rate and antinoise ability. The artificial grid graph and Magnetic Resonance Imaging (MRI) are used in the experiments, and the experimental results show that the proposed algorithm has stronger antinoise ability and higher precision. A number of evaluation indicators also demonstrate that the effect of HAFSA is more excellent than FCM and suppressed FCM (SFCM).