9 results on '"Shinohara, Naohiro"'
Search Results
2. 18F-FDG PET/CT Imaging of G-CSF–Producing Dedifferentiated Liposarcoma
- Author
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Eizuru, Yukari, Nakajo, Masatoyo, Nakajo, Masanori, Shinohara, Naohiro, and Yoshiura, Takashi
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- 2022
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3. PEG10 counteracts signaling pathways of TGF-β and BMP to regulate growth, motility and invasion of SW1353 chondrosarcoma cells
- Author
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Yahiro, Yuhei, Maeda, Shingo, Shinohara, Naohiro, Jokoji, Go, Sakuma, Daisuke, Setoguchi, Takao, Ishidou, Yasuhiro, Nagano, Satoshi, Komiya, Setsuro, and Taniguchi, Noboru
- Published
- 2019
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4. 18 F-FDG PET/CT Imaging of G-CSF–Producing Dedifferentiated Liposarcoma.
- Author
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Eizuru, Yukari, Nakajo, Masatoyo, Nakajo, Masanori, Shinohara, Naohiro, and Yoshiura, Takashi
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- 2022
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- View/download PDF
5. Long-Term Results of Kyocera Modular Limb Salvage System after Resection of Tumors in the Distal Part of the Femur: Report from Japanese Musculoskeletal Oncology Group Study.
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Nakamura, Tomoki, Matsumine, Akihiko, Toda, Yu, Takenaka, Satoshi, Outani, Hidetatsu, Fujiwara, Tomohiro, Nishida, Yoshihiro, Tsukushi, Satoshi, Tome, Yasunori, Kawamoto, Teruya, Kito, Munehisa, Shinohara, Naohiro, Tomita, Masato, Torigoe, Tomoaki, Sudo, Akihiro, and Kawano, Hirotaka
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FEMUR surgery ,ONCOLOGIC surgery ,PATIENT aftercare ,OSTEOSARCOMA ,SURGICAL complications ,CANCER relapse ,TREATMENT effectiveness ,LIMB salvage ,DESCRIPTIVE statistics ,REOPERATION ,QUESTIONNAIRES ,CHONDROSARCOMA ,AMPUTATION ,COMPLICATIONS of prosthesis ,EVALUATION - Abstract
Simple Summary: We aimed to elucidate the long-term outcomes of a distal femur reconstruction system in 125 patients with bone and soft tissue tumors. Implant survival rates at 10 and 15 years were 58.5% and 39.4%. Stem breakage should be considered in patients with cementless and/or smaller femoral stem sizes. Aseptic loosening should be considered in patients with a cement system after 10 years. Background: The distal femur is a common site of bone tumors. After surgical resection, prosthetic replacement is a major reconstruction method. We aimed to elucidate the long-term outcomes of the Kyocera Modular Limb Salvage (KMLS) systems after resection of tumors in the distal part of the femur. Methods: Between 1998 and 2014, 125 patients were treated at 14 institutions. There were 59 males and 66 females, with a mean age of 35 years. The mean follow-up period was 132 months. Results: There had been 65 additional surgeries, including 56 revisions and 9 amputations: 15 for aseptic loosening, 14 for stem breakage, 13 for deep infection, 13 for rotator-hinge bushing failure, 5 for local recurrence, and 5 for others. Implant survival rates at 10 and 15 years were 58.5% and 39.4%. The cumulative incidence of 15-year revision for femoral stem breakage was 31.7% in patients with cementless fixation. The 15-year cumulative incidence of revision for aseptic loosening was 19.8% in patients with cement fixation. Conclusions: KMLS systems represent a reliable system with long-term results. Stem breakage should be considered in patients with cementless and/or smaller femoral stem sizes. Aseptic loosening should be considered in patients with cement systems after 10 years. [ABSTRACT FROM AUTHOR]
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- 2022
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6. Benefits of Collaboration Between the Wound, Ostomy, and Continence Nurse and Orthopedic Surgeon When Treating Skin Defects After Soft Tissue Sarcoma Resection: A Retrospective Case-Control Study.
- Author
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Sasaki H, Nishiobino T, Tominaga H, Tokushige A, Shinohara N, Nagano S, and Taniguchi N
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- Humans, Retrospective Studies, Case-Control Studies, Orthopedic Surgeons, Ostomy, Sarcoma surgery
- Abstract
Purpose: The purpose of this study was to evaluate the benefits of collaborative management between orthopedic surgery and WOC nurses in patients undergoing resection of subcutaneous sarcomas., Design: Retrospective case-control study., Subjects and Setting: The sample comprised 25 patients who underwent wide resection for soft tissue sarcoma, followed by 2-stage split-thickness skin grafting. Data collection occurred between January 2015 and April 2021 in a university hospital based in Kagoshima, Japan. For comparison, we categorized these patients into 2 groups: intervention group participants were managed by an orthopedic surgeon and a WOC nurse; nonintervention group members were managed without WOC nurse participation., Methods: Patient background and treatment-related information was retrospectively collected from medical records and compared between the WOC nurse intervention group and the nonintervention group, including maximum tumor diameter, surgical time, maximum skin defect diameter, length of hospital stay, and time from surgery to complete wound healing., Results: The average length of hospital stay was significantly shorter in the WOC nurse intervention group compared with the nonintervention group (38.3 days, SD = 8.0 vs 47.1 days, SD = 10.2; P = .023)., Conclusion: Collaborative wound management with a WOC nurse resulted in a shorter hospital length of stay when compared to traditional management with WOC nurse involvement. Based on these findings, we assert that WOC nurses provide an important bridge between postoperative wound management in patients undergoing resection of subcutaneous sarcomas., Competing Interests: The authors declare no conflicts of interest associated with this article., (Copyright © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Wound, Ostomy, and Continence Nurses Society.)
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- 2024
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7. Low-grade Fibromyxoid Sarcoma With Massive Degeneration: A Case of Unusual Gross and Histological Features.
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Tasaki T, Shiba E, Noguchi H, Kirishima M, Kitazono I, Terabaru W, Tabata K, Higashi M, Shinohara N, Sasaki H, Nakajo M, Nakajo M, Hisaoka M, and Tanimoto A
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- Adult, Middle Aged, Male, Humans, Biomarkers, Tumor genetics, Fibrosarcoma diagnosis, Fibrosarcoma genetics, Fibrosarcoma surgery, Sarcoma diagnosis, Soft Tissue Neoplasms pathology
- Abstract
Background: Low-grade fibromyxoid sarcoma (LGFMS) is a rare type of sarcoma which is observed in the soft tissue of proximal extremities, typically in young and middle-aged adults. It consists of a solid proliferation of bland spindle cells within collagenous and myxoid stroma., Case Report: Herein, we report a case of LGFMS with massive degeneration and hyalinization. A 30-year-old man presented with a well-circumscribed mass measuring 15 cm in diameter in his left biceps femoris muscle. Marginal tumor resection was performed under the clinical diagnosis of an ancient schwannoma or chronic expanding hematoma (CEH). The resected tissue revealed a well-demarcated tumor mass with massive degeneration and hyalinization with focal calcification. Proliferation of spindle tumor cells with abundant collagenous stroma, which resembled the fibrous capsule of CEH, was observed exclusively in a small area of the periphery of the tumor. No nuclear palisading, myxoid stroma, or collagen rosettes were identified. Immunohistochemical analysis demonstrated that the spindle tumor cells expressed mucin 4 and epithelial membrane antigen. Reverse transcriptase-polymerase chain reaction analysis detected mRNA expression of fused in sarcoma::CAMP-responsive element binding protein 3-like protein 2 (FUS::CREB3L2) fusion gene. Thus, a final diagnosis of LGFMS with massive degeneration and FUS::CREB3L2 fusion was made., Conclusion: The recognition of massive degeneration and hyalinization as unusual features of LGFMS might be helpful to differentiate it from CEH and other benign spindle-cell tumors., (Copyright © 2023, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
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- 2023
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8. Liposarcoma of the pleural cavity.
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Kawai T, Nakashima H, Washimi K, Yokose T, Matsuo T, Nakayama M, Shinohara N, Kuroda H, Ishida K, Akiba J, Ishikawa M, Urabe S, Shiraishi J, Shiraishi T, Sakamoto A, and Matsukuma S
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- Adult, Humans, Pleural Cavity chemistry, Pleural Cavity metabolism, Pleural Cavity pathology, In Situ Hybridization, Fluorescence methods, Perilipin-2, S100 Proteins, Proto-Oncogene Proteins c-mdm2 analysis, Gene Amplification, Biomarkers, Tumor genetics, Biomarkers, Tumor analysis, Liposarcoma pathology, Lipoma diagnosis
- Abstract
Liposarcoma rarely occurs in the pleura or thoracic cavity, and few reports appear in the literature. We hypothesized that combining clinicopathologic, immunohistochemical, and fluorescence in situ hybridization methods would allow definite diagnoses. Using formalin-fixed, paraffin-embedded blocks, we examined 6 atypical lipomatous tumor/well-differentiated liposarcomas (ALT/WDLPS), 5 dedifferentiated liposarcomas (DDLPSs), 2 pleomorphic liposarcomas, and 1 myxoid liposarcoma (MLPS). We used the Kaplan-Meier method and the Wilcoxon test for survival analysis for prognostic factor evaluation. Histologically, ALT/WDLPS was composed of a relatively mature adipocytic proliferation, accompanied by some lipoblasts. DDLPS exhibited round-to-oval tumor cells with a high nucleus-to-cytoplasm ratio that had proliferated in nests, accompanied in case 10 by some giant cells but no fatty cells. The pleomorphic type contained a varying proportion of pleomorphic lipoblasts. MLPS displayed uniform round- to oval-shaped cells and small signet-ring lipoblasts in a myxoid stroma. Immunohistochemically, 11 (79%), 11 (79%), and 10 (71%) of 14 cases were positive for S-100, p16, and CDK4, respectively. Six of the 14 cases (43%) were positive for MDM2 and adipophilin. One case of ALT/WDLPS and 3 cases of DDLPS exhibited MDM2 amplification by fluorescence in situ hybridization (Vysis LSI MDM2 SpectrumGreen Probe plus Vysis CEP 12 SpectrumOrange probe). ALT/WDLPS was the most favorable type for survival, while adipophilin tended to be a negative prognostic factor for pleural liposarcoma. For a firm diagnosis of liposarcoma in the pleura, immunohistochemistry for CDK4, MDM2, and adipophilin together with MDM2 gene amplification by fluorescence in situ hybridization may be an important diagnostic tool., (Copyright © 2023 Elsevier Inc. All rights reserved.)
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- 2023
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9. TGF-β signalling and PEG10 are mutually exclusive and inhibitory in chondrosarcoma cells.
- Author
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Shinohara N, Maeda S, Yahiro Y, Sakuma D, Matsuyama K, Imamura K, Kawamura I, Setoguchi T, Ishidou Y, Nagano S, and Komiya S
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- Apoptosis Regulatory Proteins, Bone Morphogenetic Proteins metabolism, Bone Neoplasms genetics, Chondrocytes metabolism, Chondroma metabolism, Chondrosarcoma genetics, DNA-Binding Proteins, Female, Hep G2 Cells, Humans, Male, Proteins genetics, RNA-Binding Proteins, SOX9 Transcription Factor metabolism, Smad Proteins metabolism, Bone Neoplasms metabolism, Chondrosarcoma metabolism, Proteins metabolism, Signal Transduction, Transforming Growth Factor beta metabolism
- Abstract
Histological distinction between enchondroma and chondrosarcoma is difficult because of a lack of definitive biomarkers. Here, we found highly active transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) signalling in human chondrosarcomas compared with enchondromas by immunohistochemistry of phosphorylated SMAD3 and SMAD1/5. In contrast, the chondrogenic master regulator SOX9 was dramatically down-regulated in grade 1 chondrosarcoma. Paternally expressed gene 10 (PEG10) was identified by microarray analysis as a gene overexpressed in chondrosarcoma SW1353 and Hs 819.T cells compared with C28/I2 normal chondrocytes, while TGF-β1 treatment, mimicking higher grade tumour conditions, suppressed PEG10 expression. Enchondroma samples exhibited stronger expression of PEG10 compared with chondrosarcomas, suggesting a negative association of PEG10 with malignant cartilage tumours. In chondrosarcoma cell lines, application of the TGF-β signalling inhibitor, SB431542, increased the protein level of PEG10. Reporter assays revealed that PEG10 repressed TGF-β and BMP signalling, which are both SMAD pathways, whereas PEG10 knockdown increased the level of phosphorylated SMAD3 and SMAD1/5/9. Our results indicate that mutually exclusive expression of PEG10 and phosphorylated SMADs in combination with differentially expressed SOX9 is an index to distinguish between enchondroma and chondrosarcoma, while PEG10 and TGF-β signalling are mutually inhibitory in chondrosarcoma cells.
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- 2017
- Full Text
- View/download PDF
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